Rhodium versus ruthenium: contrasting behaviour in the asymmetric transfer hydrogenation of α-substituted acetophenones

Synthesis and Catalytic Applications of an Extended Range of Tethered Ruthenium(II)/η6-Arene/Diamine Complexes

“…While significant activity could be retained at S/C as high as 5,000 without loss of enantioselectivity (see Supporting Information), significant amounts of -formatoacetophenone was formed as a side product. 15 It was noteworthy that the cleanest reductions of -chloroacetophenone were achieved using the 4C tethered complexes 10g-10i…”

Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles

“…Catalysts 2017, 7, 37 2 of 13 asymmetric synthesis of fine chemicals and drugs (e.g., sertraline, nifenalol, Figure 1) [5][6][7][8] because of their versatility related to the ring strain. The oxetane skeleton is present in several natural organic products (e.g., oxetanocin, taxol, mitrophorone), and represents a versatile building block for the construction of biologically active compounds (e.g., EDO, Figure 1), or other valuable heterocyclic compounds [9][10][11].…”

“…The chemistry of saturated oxygen heterocycles is a topic of growing interest, and several papers dealing with more efficient methodologies for their preparation and their synthetic utility have been increasingly published. Epoxides, in particular, have been widely used in preparative chemistry [3,4] and in the asymmetric synthesis of fine chemicals and drugs (e.g., sertraline, nifenalol, Figure 1) [5][6][7][8] because of their versatility related to the ring strain. The oxetane skeleton is present in several asymmetric synthesis of fine chemicals and drugs (e.g., sertraline, nifenalol, Figure 1) [5][6][7][8] because of their versatility related to the ring strain.…”

“…Epoxides, in particular, have been widely used in preparative chemistry [3,4] and in the asymmetric synthesis of fine chemicals and drugs (e.g., sertraline, nifenalol, Figure 1) [5][6][7][8] because of their versatility related to the ring strain. The oxetane skeleton is present in several asymmetric synthesis of fine chemicals and drugs (e.g., sertraline, nifenalol, Figure 1) [5][6][7][8] because of their versatility related to the ring strain. The oxetane skeleton is present in several natural organic products (e.g., oxetanocin, taxol, mitrophorone), and represents a versatile building block for the construction of biologically active compounds (e.g., EDO, Figure 1), or other valuable heterocyclic compounds [9][10][11].…”

Five‐Membered Heterocycles with Two Heteroatoms: O and S Derivatives

“…The transfer hydrogenation of the tosylacetophenone 62 using a chiral ruthenium catalyst and formic acid as the hydrogen source unexpectedly gives the chiral dioxolanone 63 in 94% ee (Scheme 11.18) [52]. 1,2-Diols like 64 react with oxalyl chloride and triethylamine to give the 1,3-dioxolanone 65 rather than the expected six-membered ring products (Scheme 11.19) [53].…”