Rhodiola rosea-Spezialextrakt SHR-5 bei Burn-out und Erschöpfungssyndrom

Goyvaerts, Birgit; Bruhn, Stefan

doi:10.1055/s-0031-1298676

Cited by 6 publications

(7 citation statements)

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“…Investigating these effects of R. rosea, a non-interventional study was conducted in 128 primary care practices in Germany, including 330 patients with burnout indicator symptoms (exhaustion, depression, insomnia, fatigue or drop in performance). A considerable alleviation of these complaints after the administration of R. rosea over 8 weeks was reported, along with very good tolerability [16]. Likewise, in a double-blind, placebo-controlled clinical trial, 60 participants, selected according to the diagnostic criteria for fatigue syndrome, were randomized to receive R. rosea (576 mg extract/day) or placebo for four weeks [17].…”

Section: Asthenia and Resiliencementioning

confidence: 99%

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

Stojcheva¹,

Quintela²

2022

Molecules

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Rhodiola rosea L. has a long history of use in traditional medicine to stimulate the nervous system, treat stress-induced fatigue and depression, enhance physical performance and work productivity and treat gastrointestinal ailments and impotence. Apart from its well-established traditional use, a significant number of publications on the clinical efficacy of various R. rosea preparations can be found in the literature. The majority of these studies are related to the efficacy of R. rosea in terms of cognitive functions and mental performance, including various symptoms of life-stress, fatigue and burnout. The beneficial effects of this medicinal plant on enhancing physical performance have also been evaluated in professional athletes and non-trained individuals. Moreover, even though most evidence originates from pre-clinical trials, several clinical studies have additionally demonstrated the remediating effects of R. rosea on cardiovascular and reproductive health by addressing non-specific stress damage and reversing or healing the disrupted physiologies and disfunctions. Overall, in accordance with its aim, the results presented in this review provide an encouraging basis for the clinical efficacy of R. rosea preparations in managing various aspects of stress-induced conditions.

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Section: Asthenia and Resiliencementioning

confidence: 99%

The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

Stojcheva¹,

Quintela²

2022

Molecules

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“…A German noninterventional study conducted in 128 general practitioner (GP) practices including 330 patients with two or more burnout indicator symptoms, as assessed on a basic, self-rating questionnaire, also reported a considerable alleviation of these symptoms after the administration of R. rosea extract for 8 weeks 28. Beneficial effects of R. rosea extract on emotional instability and somatization as symptoms of mild to moderate depression were demonstrated by Darbynian et al29 This is of particular interest as these symptoms – when associated with stress – are also regarded as indicators of burnout 6,9…”

Section: Introductionmentioning

confidence: 99%

Multicenter, open-label, exploratory clinical trial with <em>Rhodiola rosea</em> extract in patients suffering from burnout symptoms

Kasper

Dienel²

2017

NDT

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PurposeThis study is the first clinical trial aiming to explore the clinical outcomes in burnout patients treated with Rhodiola rosea. The reported capacity of R. rosea to strengthen the organism against stress and its good tolerability offer a promising approach in the treatment of stress-related burnout. The aim of the treatment was to increase stress resistance, thus addressing the source rather than the symptoms of the syndrome and preventing subsequent diseases associated with a history of burnout. The objective of the trial was to provide the exploratory data required for planning future randomized trials in burnout patients in order to investigate the clinical outcomes of treatment with R. rosea dry extract in this target group.MethodsThe study was planned as an exploratory, open-label, multicenter, single-arm trial. A wide range of rating scales were assessed and evaluated in an exploratory data analysis to generate hypotheses regarding clinical courses and to provide a basis for the planning of subsequent studies. A total of 118 outpatients were enrolled. A daily dose of 400 mg R. rosea extract (WS® 1375, Rosalin) was administered over 12 weeks. Clinical outcomes were assessed by the German version of the Maslach Burnout Inventory, Burnout Screening Scales I and II, Sheehan Disability Scale, Perceived Stress Questionnaire, Number Connection Test, Multidimensional Mood State Questionnaire, Numerical Analogue Scales for different stress symptoms and impairment of sexual life, Patient Sexual Function Questionnaire, and the Clinical Global Impression Scales.ResultsThe majority of the outcome measures showed clear improvement over time. Several parameters had already improved after 1 week of treatment and continued to improve further up to the end of the study. The incidence of adverse events was low with 0.015 events per observation day.DiscussionThe trial reported here was the first to investigate clinical outcomes in patients suffering from burnout symptoms when treated with R. rosea. During administration of the study drug over the course of 12 weeks, a wide range of outcome measures associated with the syndrome clearly improved.ConclusionThe results presented provide an encouraging basis for clinical trials further investigating the clinical outcomes of R. rosea extract in patients with the burnout syndrome.

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“…Investigating the effects of RRE on burnout-related symptoms, a German non-interventional study was conducted in 128 primary care practices and included 330 patients with two or more burnout indicator symptoms (exhaustion, depression, insomnia, fatigue or drop in performance). A considerable alleviation of these symptoms after the administration of RRE for eight weeks was reported based on the results of the self-rating questionnaires used in this trial (Goyvaerts & Bruhn, 2012).…”

Section: Burnout Symptomsmentioning

confidence: 70%

“…Reported symptoms of burnout comprise not only psychiatric or mood disorders such as fatigue, cynicism, impaired sexual life, lack of concentration or a generally negative attitude toward work, but also somatic symptoms such as headaches, hypertension or irritable stomach. Treatment with RRE for eight and 12 weeks, respectively, was accompanied by a clear improvement in burnout symptoms (Table 3; Goyvaerts & Bruhn, 2012;Kasper & Dienel, 2017).…”

Section: Burnout Symptomsmentioning

confidence: 98%