Stress management and the role of <i>Rhodiola rosea</i>: a review

Anghelescu, Ion‐George; Edwards, David Hughes; Seifritz, Erich; Kasper, Siegfried

doi:10.1080/13651501.2017.1417442

Cited by 46 publications

(39 citation statements)

References 43 publications

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“…Psychological stress has been associated with alteration of the immune system. Anghelescu et al (115) suggested that this response is most likely due to complex interactions between the neuro-endocrine-immune pathways, in which the primary mediators include hormones of the hypothalamic-pituitary-adrenal axis, catecholamines, and cytokines. To maintain homeostasis in a condition of stress, corticotropin-releasing hormone can be stimulated, which subsequently induces the release of adrenocorticotropic hormone as well as the downstream factors adrenaline, noradrenaline, and cortisol (115).…”

Section: Trauma-related Triggers Of Gbs and Underlying Mechanismsmentioning

confidence: 99%

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

et al. 2020

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Guillain-Barré syndrome (GBS) is mainly associated with preceding exposure to an infectious agent, although the precise pathogenic mechanisms and causes remain unknown. Increasing evidence indicates an association between trauma-related factors and GBS. Here, we performed a systematic review, summarized the current scientific literature related to the onset of GBS associated with trauma, and explored the possible pathogenesis. A literature search of various electronic databases was performed up to May 2020 to identify studies reporting diverse trauma-related triggers of GBS. Data were extracted, summarized descriptively, and evaluated with respect to possible mechanisms. In total, 100 publications, including 136 cases and 6 case series involving GBS triggered by injury, surgery, intracranial hemorrhage, and heatstroke, met our eligibility criteria. The median age of the patients was 53 [interquartile range (IQR) 45-63] years, and 72.1% of the patients were male. The median number of days between the trigger to onset of GBS symptoms was 9 (IQR 6.5-13). Overall, 121 patients (89.0%) developed post-injury/surgical GBS, whereas 13 (9.6%) and 2 (1.5%) patients had preexisting spontaneous intracranial hemorrhage and heatstroke, respectively. The main locations of injury or surgeries preceding GBS were the spine and brain. Based on available evidence, we highlight possible mechanisms of GBS induced by these triggers. Moreover, we propose the concept of "trauma-related GBS" as a new research direction, which may help uncover more pathogenic mechanisms than previously considered for typical GBS triggered by infection or vaccination.

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Section: Trauma-related Triggers Of Gbs and Underlying Mechanismsmentioning

confidence: 99%

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

et al. 2020

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“…One popular plant is Rhodiola rosea L. (golden root, roseroot; synonym Sedum roseum (L.) Scop., Crassulaceae family), a medicinal species with a disjunct distribution in Eurasia and known as a medical remedy [1]. The roots and rhizome of R. rosea are the source of numerous metabolites, like acyclic alcohol derivatives, benzyl glucosides, phenols, hydroxycinnamates, gallotannins, flavonoids, catechins, procyanidins, and terpenes [2], with a diversity of bioactivities as antioxidant [3], anticancer [4], antidiabetic [5], antidepressant, neuroprotective [6], anti-inflammatory [7], and adaptogenic [8] agents. The main reserves of R. rosea are concentrated in Siberian regions such as Altai, Western Sayans, and Tuva [9].…”

Section: Introductionmentioning

confidence: 99%

LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs

et al. 2020

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Golden root (Rhodiola rosea L., Crassulaceae) is a famous medical plant with a one-sided history of scientific interest in the roots and rhizomes as sources of bioactive compounds, unlike the herb, which has not been studied extensively. To address this deficiency, we used high-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection for comparative qualitative and quantitative analysis of the metabolic profiles of Rhodiola rosea organs before and after gastrointestinal digestion in simulated conditions together with various biochemical assays to determine antioxidant properties of the extracts and selected compounds. R. rosea organs showed 146 compounds, including galloyl O-glucosides, catechins, procyanidins, simple phenolics, phenethyl alcohol derivatives, (hydroxy)cinnamates, hydroxynitrile glucosides, monoterpene O-glucosides, and flavonol O-glycosides, most of them for the first time in the species. The organ-specific distribution of compounds found for catechins, procyanidins, and cinnamyl alcohols and glucosides was typical for underground organs and flavonoids and galloylated glucoses concentrated in the herb. Extracts from rhizomes, leaves and flowers showed high phenolic content and were effective scavengers of free radicals (2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), O2•−, •OH) and protected β-carotene in a bleaching assay. Digestion in the gastric and intestine phase influenced the composition of R. rosea extracts negatively, affecting the content of catechins, procyanidins, and galloyl glucoses, and therefore, the antioxidativity level. After gut microbiota treatment, the antioxidant capacity of rhizome extract was lower than leaves and flowers due to the aglycone composition found in the colonic phase of digestion. Our study demonstrated that the herb of R. rosea is a rich source of metabolites with high antioxidant properties and could be a valuable plant for new bioactive products.

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“…R. rosea is more known for its adaptogenic properties than antidepressant effects, and has proven benefits in patients with stress-related fatigue and anxiety. 35 – 37 An anxiolytic effect has also been reported for saffron. 22 , 38 In our study, after 6 weeks of supplementation with a combination of rhodiola and saffron, HADS anxiety scores were reduced significantly by >30%.…”

Section: Discussionmentioning

confidence: 90%

A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression

Bangratz¹,

Abdellah²,

Berlin³

et al. 2018

NDT

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ObjectiveThe medicinal plants Rhodiola rosea L. (rhodiola, golden root) and Crocus sativus L. (saffron) have been shown separately to induce significant effects in depression. The objective of this study was to assess a fixed combination of rhodiola and saffron in mild–moderate depression.MethodsIn this observational study conducted with general practitioners (GPs), 45 adults (aged 18–85 years) suffering from mild or moderate depression (International Statistical Classification of Diseases and Related Health Problems 10th Revision definition) and reaching a score on the Hamilton Rating Scale for Depression of 8–18 were supplemented with a combination of rhodiola and saffron extracts (one tablet, 154 mg of rhodiola and 15 mg of saffron; recommended dose two tablets per day for 6 weeks).ResultsAfter 6 weeks (D42) of supplementation, Hamilton Rating Scale for Depression scores (primary outcome) decreased significantly by 58%±28.5% (from 13.6±2.3 at D0 to 5.6±3.8 at D42, P<0.0001; n=41). Score improvement was reported in 85.4% of patients. A significant drop in both Hospital Anxiety and Depression Scale anxiety and depression scores was also observed at D42, the decrease being significant from 2 weeks of supplementation. At the end of the study, both GPs and patients deemed there was a significant improvement in depression (Clinical Global Impression – improvement and Patient Global Impression of Change). Safety was excellent, and no serious adverse effects were recorded.ConclusionResults of this observational study performed in primary care suggest that the combination of rhodiola and saffron tested could be useful for the management of mild–moderate depression and improve depressive and anxiety symptoms. A double-blind placebo-controlled study is needed to confirm these results.

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Stress management and the role of Rhodiola rosea: a review

Cited by 46 publications

References 43 publications

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs

A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression

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Stress management and the role of Rhodiola rosea: a review

Cited by 46 publications

References 43 publications

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept

LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs

A preliminary assessment of a combination of rhodiola and saffron in the management of mild&ndash;moderate depression

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A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression