Rhodiola plants: Chemistry and biological activity

Chiang, Hsiu-Mei; Chen, Hsin-Chun; Wu, Chin-Sheng; Wu, Po-Yuan; Wen, Kuo‐Ching

doi:10.1016/j.jfda.2015.04.007

Cited by 147 publications

(102 citation statements)

References 90 publications

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“…This species is mainly distributed in high altitudes of >2,000 m in the Arctic and mountainous regions throughout Asia and Europe. This typical alpine plant has been widely used as an important food crop and folk medicine since ancient times by many countries, such as Sweden, Russia, India, and China (Chiang et al, 2015). Rhodiola rhizome, as a traditional folk medicine, stimulates mental and physical endurance, counteracts depression, improves sleep quality, and prevents high-altitude sickness.…”

Section: Rhodiola Spp (Crassulaceae)mentioning

confidence: 99%

“…Modern pharmacology research suggests that Rhodiola rhizome has received considerable attention because of its biological behavior, including antioxidant and anti-aging properties, anti-microwave radiation, antihypoxia and adaptogenic activities. Most of these eff ects are ascribed to phenolics, such as salidrosides and p-tyrosol, and glycosides like rosavins (Chiang et al, 2015).…”

Section: Rhodiola Spp (Crassulaceae)mentioning

confidence: 99%

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Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefi ts. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very eff ective and have relatively less or no side eff ects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5x106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.Additional key words: metabolites from endophytic bacteria and actinomycetes, chemical ecology present in virtually all organs of a given plant host, and some are seed borne. Endophytes often confer considerable benefi ts to the host plant they inhabit, since they can promote the growth of host plants, enhance resistance to biotic and abiotic stresses (Rodriguez et al., 2009; Hardoim et al., 2015), and accumulate bioactive secondary metabolites (Kusari et al., 2012). The ecological role of secondary metabolites produced by endophytes is not clear. However, recent studies have shown that these metabolites are involved in deterrence of herbivory (Pannaccione et al., 2014), protection against fungal (Soliman et al., 2015) or bacterial pathogens (Mousa et al., 2017) and amelioration of plant abiotic stress (Hamayum et al., 2016). Bioactive secondary metabolites derived from medicinal plants are gradually decreasing -Alternative approaches for their productionMedicinal plants, as a rich source of nat-

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Section: Rhodiola Spp (Crassulaceae)mentioning

confidence: 99%

Section: Rhodiola Spp (Crassulaceae)mentioning

confidence: 99%

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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“…The analysis of the data has revealed multiple transcriptional alterations, affecting the expression Chiang et al 2015). It is becoming increasingly clear that several mechanisms contribute to the adaptogenic activities of R. rosea preparations and its phytochemical components Panossian et al, 2010a).…”

Section: Phytochemical Composition Of Rhodiola Roseamentioning

confidence: 99%

“…R. rosea extracts, as well as its valuable pharmacologically active substances, such as salidroside, tyrosol, and rosavins, are extensively studied for their neuroprotective (Chen et al 2008), hepatoprotective (Wu et al 2009), antioxidant (Chen et al 2009), antiviral ), anticancer (Hu et al 2010) and anti-inflammatory activities (Guan et al 2011a). Scientific research and clinical studies have confirmed the safety of R. rosea and its effectiveness as a psychostimulant, general strengthener, and antistress agent (Chiang et al 2015). Understanding the signalling and regulatory system functioning on cellular level is important in elucidation the defence mechanism and the specific features of the adaptogenic activity (Volkova et al 2013).…”

mentioning

confidence: 99%

Rhodiola rosea L.: from golden root to green cell factories

et al. 2016

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“…It was used as food crop and folk medicine by many ancient civilizations because of its pharmacologic effects, such as antioxidant, anti-fatigue, anti-aging, as well as adaptogenic properties [3]. With increasing demand for SAL and TYR as additives in the health food, cosmetic, and pharmaceutical industries, wild Rhodiola plants are being over-exploited [4].…”

Section: Introductionmentioning

confidence: 99%

Potential of the Endophytic Fungus Phialocephala fortinii Rac56 Found in Rhodiola Plants to Produce Salidroside and p-Tyrosol

et al. 2016

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2-(4-Hydroxyphenyl)ehyl-β-D-glucopyranoside (salidroside) and 4-(2-hydroxyethyl)phenol (p-tyrosol) are famous food and medicine additives originally derived from alpine Rhodiola plants. Salidroside or p-tyrosol production by the endophytic fungus Rac56 (Phialocephala fortinii) was confirmed by UPLC/Q-TOF-MS and 1 H-NMR. The fermentation conditions were optimized by orthogonal design using data processing system software. The broth fermentation results showed that salidroside and p-tyrosol extraction yields from Rac56 were stable and reached 1.729˘0.06 mg and 1.990˘0.05 mg per mL of culture medium, respectively. The optimal conditions for salidroside and p-tyrosol production in fermentation culture of Rac56 were determined to be 25˝C, pH values of 7 and 5, Czapek-Dox culture medium volumes of 150 mL and 50 mL in 250 mL flasks, rotation speeds of 100ˆg and 200ˆg, and fermentation durations of 7 and 15 days, respectively. Under these optimal conditions, stable yields of 2.339˘0.1093 mg and 2.002˘0.0009 mg per mL of culture medium of salidroside and p-tyrosol, respectively, were obtained, indicating that the P. fortinii Rac56 strain is a promising source of these compounds.

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Rhodiola plants: Chemistry and biological activity

Cited by 147 publications

References 90 publications

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Rhodiola rosea L.: from golden root to green cell factories

Potential of the Endophytic Fungus Phialocephala fortinii Rac56 Found in Rhodiola Plants to Produce Salidroside and p-Tyrosol

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