Rhinovirus‐specific antibody responses in preschool children with acute wheeze reflect severity of respiratory symptoms

Stenberg‐Hammar, Katarina; Niespodziana, Katarzyna; Söderhäll, Cilla; James, Anna; Cabauatan, Clarissa R.; Konradsen, Jon R.; Melén, E.; Hage, Marianne van; Valenta, Rudolf; Hedlin, Gunilla

doi:10.1111/all.12991

Cited by 21 publications

(50 citation statements)

References 25 publications

(36 reference statements)

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“…Viral infections are the most frequent cause behind the wheezing symptom. In recent reports on preschool children presenting at the hospital with acute wheeze, RV was detected in almost 70% of them . Despite its high prevalence, there is a lack of evidence and mixed results regarding the pharmacological treatment .…”

Section: Preschool Wheezementioning

confidence: 99%

Rhinovirus and preschool wheeze

Stenberg‐Hammar

Hedlin

Söderhäll

2017

Pediatric Allergy Immunology

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Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are, however, conflicting opinions as to whether there are differences in response to RV infection or whether wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children. The advent of molecular diagnostics to detect respiratory viruses has led to new insights into the role of RV infections. This review will discuss recent information concerning the role of RV as an important respiratory pathogen related to early onset wheeze and exacerbation of established asthma in preschool children.

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Section: Preschool Wheezementioning

confidence: 99%

Rhinovirus and preschool wheeze

Stenberg‐Hammar

Hedlin

Söderhäll

2017

Pediatric Allergy Immunology

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“…Moreover, it has been found that the natural immune response towards rhinovirus, the most common asthma-triggering respiratory virus, is directed against an N-terminal peptide of the VP1 coat protein [30]. It has therefore become possible to detect rhinovirus infections by measuring specific antibody responses against this VP1 peptide [31][32][33].…”

Section: Protein Biomarkers and Their Role In Asthmamentioning

confidence: 99%

“…New forms of molecular biology tests, based on molecular cloning, have been proposed for determination of diseases caused by allergen molecules and respiratory virus infections in routine practice, which allow distinguishing and separating those groups of patients. For example, for identifying causative rhinovirus groups, measurement of antibodies towards N-terminal fragments of the human rhinovirus coat protein VP1 can be useful [31,32]. Specific IgE towards single allergen molecules or complex IgE and IgG reactivity profiles can be biomarkers and even predictors of allergic asthma.…”

Section: Biomarkers In Phenotyping and Endotyping Of Asthmamentioning

confidence: 99%

“…1). Similar tests are now becoming available also for rhinovirus-induced asthma, which is very important in childhood [31,32].…”

Section: Outdoor Allergens and Pediatric Asthmamentioning

confidence: 99%

“…Importantly, allergen microarrays allow determination of sensitization to respiratory allergens and the culprit allergen source quickly and hence are ideal first-line tests for the diagnosis of allergic asthma. Similar antibody-based tests are currently being developed to identify respiratory viruses as culprit agents for asthma so that it will be soon possible to firmly differentiate between allergic and virus-induced forms of asthma [31,32]. Another important result from recently conducted birth cohort studies is that it seems to be possible to predict the development of allergic respiratory diseases according to "clinically silent" IgE reactivity profiles measured early in the life of children (Fig.…”

Section: Outdoor Allergens and Pediatric Asthmamentioning

confidence: 99%

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Protein Biomarkers in Asthma

Karaulov

Garib

et al. 2018

Int Arch Allergy Immunol

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Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.

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