Rhinovirus and preschool wheeze

Stenberg‐Hammar, Katarina; Hedlin, Gunilla; Söderhäll, Cilla

doi:10.1111/pai.12740

Cited by 19 publications

(18 citation statements)

References 88 publications

(201 reference statements)

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“…Interestingly, we observed the association of elder age and higher house‐dust mite IgE levels with single infection in multiple logistic analyses. Allergic sensitization was suggested as leading to increased susceptibility to RV, and RV‐associated wheeze . Our results confirmed the reported finding of exacerbation of asthma associated with RV.…”

Section: Discussionsupporting

confidence: 91%

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Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

Abe

Yasudo

Fukano

et al. 2019

Pediatric Allergy Immunology

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Background Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three‐year period. Methods Hospitalized asthmatic children with attack aged 6 months‐17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription‐polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV‐associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV‐D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion Our three‐year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV‐associated asthma development and exacerbation. Multiple‐year monitoring allowed us to comprehend the profile of virus‐ and/or mycoplasma‐induced asthma exacerbation.

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Section: Discussionsupporting

confidence: 91%

“…Allergic sensitization was reported to be related to RV‐associated wheeze . Interestingly, we observed a closer association of house‐dust mite–specific IgE with the RV group than with the RSV group.…”

Section: Discussionsupporting

confidence: 47%

Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

Abe

Yasudo

Fukano

et al. 2019

Pediatric Allergy Immunology

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“…There is an increasing prevalence of these airways diseases, rising treatment costs, and therefore virus-induced respiratory illnesses are a heavy burden for patients and the community 4,5 . Respiratory viral infections, mainly due to rhinovirus (RV), are responsible for approximately 80% of wheeze and asthma exacerbations in children 6,7 . Moreover, infants with rhinovirus-induced wheeze have a significantly increased risk for subsequent development of recurrent wheeze and childhood asthma 8 .…”

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confidence: 99%

PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze

et al. 2018

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Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology. Importantly, we identify RV-A and RV-C species as giving rise to most severe respiratory symptoms. Thus, we have generated a chip for the serological identification of RV-induced respiratory illness which should be useful for the rational development of preventive and therapeutic strategies targeting the most important RV types.

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“…Wheezing is most often triggered by the blockage of the lower respiratory tract (1). Wheezing can in ict anywhere in the intrathoracic trachea, induce in ammation and mucus production in the airways, and promote reversible tightening of the smooth muscles in the airways walls (2). The sound of wheezing is induced by the turbulent air ow in the large airways which collapse upon expiration.…”

Section: Introductionmentioning

confidence: 99%

The Early-Life Risk Factors of Childhood Wheezing: Results from the NHANES During 2005-2012

Moradzadeh

Zamanian

2020

Preprint

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Abstract Objectives: Wheezing is the most common cause of hospitalization during childhood. The aim of the present study was to identify early-life risk factors predisposing to childhood wheezing using directed acyclic graph (DAG) analysis.Methods: In this study, we used the National Health and Nutrition Examination Survey (NHANES) data to identify the risk factors associated with wheezing in children aged 1-15 years old in the United States. The data was related to four 2-year cycles from 2005 to 2012. All the adjusted analyses were based on the directed acyclic graph(DAG). The applied logistic regression was performed by survey analysis to adjust the weights of samples.Results: From 13203 children, 87.2% (n = 11 519) had not experienced wheezing during the past year, and 12.8% (n=1684) experienced wheezing during the same time. The mean ages (SD) were 6.6 (4.4) and 7.6 (4.4) years old in wheezing and healthy children respectively. Boys comprised a significantly higher ratio in wheezing compared with healthy children (P = 0.001). Mother smoking during pregnancy (MSDP) was a significant risk factor for childhood wheezing (OR= 1.42, 95% CI: 1.15-1.74, P = 0.001). All ethnicities other than the Mexican-American were established as significant risk factors for childhood wheezing. On the other hand, childhood wheezing was insignificantly associated with Socio-economic status, birth weight, maternal age at pregnancy, and exposure to smoke at home.Conclusion: After adjusting for established confounders, history of MSDP, as well as ethnicity delivered important risk factors for childhood wheezing in a large population of the US.

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Rhinovirus and preschool wheeze

Cited by 19 publications

References 88 publications

Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze

The Early-Life Risk Factors of Childhood Wheezing: Results from the NHANES During 2005-2012

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