Multi‐season analyses of causative pathogens in children hospitalized with asthma exacerbation

Abstract

Background Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three‐year period. Methods Hospitalized asthmatic children with attack aged 6 months‐17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription‐polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV‐associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV‐D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion Our three‐year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV‐associated asthma development and exacerbation. Multiple‐year monitoring allowed us to comprehend the profile of virus‐ and/or mycoplasma‐induced asthma exacerbation.

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

“…One previous study 3 found upper respiratory tract signs in 25% of cats diagnosed with asthma or bronchitis whereas another 13 reported nasal discharge more often in cats with chronic bronchitis than in those with asthma. An association of asthma with upper respiratory viruses has been noted in children, 37,38 and nasal airways in cats with experimentally induced asthma were noted to have eosinophilic infiltration in the absence of clinical signs 39 . Whether this finding was related to the method of hypersensitization via aerosolized allergen in the experimental study or represented a distinct response of the upper respiratory epithelium in those cats is unclear.…”

Transtorno de Personalidade Borderline: Uma Revisão Sistemática

“…Foi observado que o rinovírus foi o vírus mais comumente detectado nos participantes com infecção única, com 48% em relação aos outros, o rinovírus também foi associado a asma exacerbada com difícil controle e sensibilização de alérgenos (ABE et al, 2019).…”

COVID‐19 and its impact on allergic and immunologic diseases in children

“…Risk domains in the long-term management of asthma have recently been developed in PAI, 18 as well as various environmental and infectious factors promoting asthma exacerbations. 19,20 At the end of this editorial, I would like to acknowledge the strong commitment of our contributors, the reviewers, and the editorial team for a fast and efficient production of this thematic issue of PAI I hope you will enjoy reading.…”

“…The authors underline the importance of enhanced patient care in children with asthma in order to achieve the ultimate goal of preventing asthma exacerbations. Risk domains in the long‐term management of asthma have recently been developed in PAI, 18 as well as various environmental and infectious factors promoting asthma exacerbations 19,20 …”