Rhinovirus species and clinical characteristics in the first wheezing episode in children

Turunen, Riitta; Jartti, Tuomas; Bochkov, Yury A.; Gern, James E.; Vuorinen, Tytti

doi:10.1002/jmv.24587

Cited by 31 publications

(33 citation statements)

References 44 publications

(101 reference statements)

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“…Additional studies with RV have demonstrated increased rates of atopic sensitization following infection [33][34][35]. In a cohort of 111 patients aged 3 to 23 months with wheeze, atopic sensitization was noted in 23% of all patients; further, RV infection was positively associated with age and other atopic factors including blood eosinophil count, eczema, cough duration and parental allergic rhinitis [33].…”

Section: Atopic Sensitization In Early Life and Environmental Exposuresmentioning

confidence: 98%

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment

Martorano

Grayson

2018

Eur J Immunol

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Atopic sensitization and allergic diseases are increasing in modernized countries. These diseases affect millions of individuals, but the mechanisms behind their development are not fully understood. One hypothesis relates to early life respiratory viral infections driving the development of atopic disease including asthma. This review presents the current state of the field, focusing on epidemiologic data supporting a role for early life respiratory viruses in the development of specific IgE, both against aeroallergens and the respiratory virus. Our own work using the Sendai mouse model is then summarized to provide a potential mechanistic explanation for how a respiratory viral infection could drive development of atopic sensitization and disease. We then discuss the components of this mechanistic pathway that have and have not been validated in humans. Finally, we discuss areas ripe for research, as well as potential and current therapeutics that might disrupt the link between respiratory viral infections in early life and atopic sensitization/disease.

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Section: Atopic Sensitization In Early Life and Environmental Exposuresmentioning

confidence: 98%

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment

Martorano

Grayson

2018

Eur J Immunol

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“…Rhinoviruses (RVs) are RNA viruses belonging to the family Picornaviridae genus Enterovirus , which has been classified into 3 species (A to C) with over 160 serotypes 64–67 . RVs are small single‐stranded RNA viruses with an icosahedral symmetrical capsid 68 .…”

Section: Rhinovirus and Its Diagnostic Approachesmentioning

confidence: 99%

“…RVs are the most frequent cause of respiratory tract infections in both children and adults. RV‐A and RV‐C are common RV species causing lower airway illness, wheezing and acute asthma, and they can lead to more severe symptoms than RV‐B in children 67,69 …”

Section: Rhinovirus and Its Diagnostic Approachesmentioning

confidence: 99%

Recent advances in the detection of respiratory virus infection in humans

Zhang

Wang

Deng

et al. 2020

Journal of Medical Virology

430

363

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Respiratory tract viral infection caused by viruses or bacteria isone of the most common diseases in human worldwide, while those caused by emerging viruses, such as the novel coronavirus, 2019-nCoV that caused the pneumonia outbreak in Wuhan, China most recently, have posed great threats to global public health. Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people's lives, stop the epidemics, and avoid unnecessary use of antibiotics. Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. With the development of modern technologies, new diagnostic strategies, including multiplex nucleic acid amplification and microarray-based assays, are emerging. This review summarizes currently available and novel emerging diagnostic methods for the detection of common respiratory viruses, such as influenza virus, human respiratory syncytial virus, coronavirus, human adenovirus, and human rhinovirus. Multiplex assays for simultaneous detection of multiple respiratory viruses are also described. It is anticipated that such data will assist researchers and clinicians to develop appropriate diagnostic strategies for timely and effective detection of respiratory virus infections. K E Y W O R D S adenovirus, coronavirus, diagnostic methods, influenza virus, respiratory syncytial virus, respiratory viral infection, rhinovirus

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“…The sequencing of 5′ NCR was performed as previously described (25). The amplification and sequencing method for VP4/VP2 region is also described in a recent publication (28). …”

Section: Methodsmentioning

confidence: 99%

Clinical and Virus Surveillance After the First Wheezing Episode

Turunen

Vuorinen

Bochkov

et al. 2017

Pediatric Infectious Disease Journal

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Background Susceptibility to rhinovirus (RV) induced early wheezing episode has been recognized as an important risk factor for asthma but the data on different RV species is limited. Our aim was to investigate the risk for recurrences in first-time wheezing children with special focus on RV species. Methods First-time wheezing children (88/23 in-/outpatients) were prospectively followed at 2-week, 2-month and 12-month time-points, and at first recurrence within 12 months. The respiratory virus etiology was analyzed using PCR. RV positive samples were sequenced. The primary outcomes were time to a new physician-confirmed wheezing episode and time to the initiation of regular controller medication for asthma symptoms. Results The median age of the children was 12 months (SD 6.0), 67% were males and 23% were sensitized. RV dominated in symptomatic and asymptomatic infections. Different virus strains caused 97 % of the consecutive RV infections. First-time wheezing children with RV-C (respectively 3.6; p < 0.001) and RV-A (hazard ratio 3.6, p = 0.002) had an increased risk for a new wheezing episode than non-RV group. Also, the risk for the initiation of regular controller medication was increased in RV-A and RV-C groups (both p < 0.05), respectively. There was no difference in response on oral prednisolone between RV-A and RV-C. Conclusions RV causes reinfections with different strains in small children after the first wheezing episode. Both RV-A and RV-C affected children have an increased risk for recurrence and initiation of regular controller medication than those with other viruses.

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Rhinovirus species and clinical characteristics in the first wheezing episode in children

Cited by 31 publications

References 44 publications

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment

Recent advances in the detection of respiratory virus infection in humans

Clinical and Virus Surveillance After the First Wheezing Episode

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