Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin‐8 release

Bossios, Apostolos; Gourgiotis, Dimitrios; Skevaki, Chrysanthi; Saxoni-Papageorgiou, Photini; Lötvall, Jan; Psarras, Stelios; Karpathios, Themistocles; Constandopoulos, A. G.; Johnston, Sebastian L.; Papadopoulos, Nikolaos G.

doi:10.1111/j.1365-2222.2008.03058.x

Cited by 47 publications

(44 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allergic patients seem to clear viral infections less effectively than healthy individuals, which is in agreement with the in vitro observation of an attenuated inflammatory response of airway epithelial cells to HRV after house dust mite exposure 33. However, the functional relevance still remains unclear since allergy does not necessarily alter symptomatology or inflammation during a common cold34 (see additional information in online supplement).…”

Section: Exogenous Factors Associated With Upper Airway Inflammationsupporting

confidence: 77%

A chest physician's guide to mechanisms of sinonasal disease

Hox

Maes

Huvenne

et al. 2015

Thorax

View full text Add to dashboard Cite

Section: Exogenous Factors Associated With Upper Airway Inflammationsupporting

confidence: 77%

A chest physician's guide to mechanisms of sinonasal disease

Hox

Maes

Huvenne

et al. 2015

Thorax

View full text Add to dashboard Cite

“…We showed that rhinovirus and Der f1 are synergistic with regard to the induction of IL-8, but this synergy was not observed in the case of RSV or adenovirus. Bossios et al25 described the stimulation of IL-8 release from BEAS-2B cells by the HDM Dermatophagoides pteronyssinus major allergen 1 (Der p 1), HRVs (HRV1b or HRV16), or both in different sequences. In these experiments, both rhinovirus and Der p 1 induced IL-8, IL-6, IL-29, and IP-10, while RANTES was induced only by rhinovirus.…”

Section: Discussionmentioning

confidence: 99%

Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses

Chun

Park

Lee

et al. 2013

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

PurposeThe environmental factors human rhinoviruses (HRVs) and house dust mites (HDMs) are the most common causes of acute exacerbations of asthma. The aim of this study was to compare the chemokine production induced by HRVs in airway epithelial cells with that induced by other respiratory viruses, and to investigate synergistic interactions between HRVs and HDMs on the induction of inflammatory chemokines in vitro.MethodsA549 human airway epithelial cells were infected with either rhinovirus serotype 7, respiratory syncytial virus (RSV)-A2 strain, or adenovirus serotype 3 and analyzed for interleukin (IL)-8 and regulated on activation, normal T-cell expressed and secreted (RANTES) release and mRNA expression. Additionally, activation of nuclear factor (NF)-κB and activator protein (AP)-1 were evaluated. The release of IL-8 and RANTES was also measured in cells stimulated simultaneously with a virus and the HDM allergen, Der f1.ResultsHRV caused greater IL-8 and RANTES release and mRNA expression compared with either RSV or adenovirus. NF-κB and AP-1 were activated in these processes. Cells incubated with a virus and Der f1 showed an increased IL-8 release. However, compared with cells incubated with virus alone as the stimulator, only HRV with Der f1 showed a statistically significant increase.ConclusionsIL-8 and RANTES were induced to a greater extent by HRV compared with other viruses, and only HRV with Der f1 acted synergistically to induce bronchial epithelial IL-8 release. These findings may correspond with the fact that rhinoviruses are identified more frequently than other viruses in cases of acute exacerbation of asthma.

show abstract

“…Although many viruses have been recovered from asthmatics, rhinovirus has been most commonly (≥65%) identified in proven viral-induced asthma exacerbations in children aged 2–17 years [14]. Allergen exposure can cause disease exacerbations in children with atopic asthma [15], and viral infections and allergen exposure likely have synergistic effects on exacerbations in these children [16]. Other risk factors for asthma exacerbations include non-white race [8], younger age [11], season [12], ETS exposure [17], and outdoor air pollution [18 • ].…”

Section: Risk Factors For Asthma Exacerbationsmentioning

confidence: 99%

Predicting asthma exacerbations in children

Forno

Celedón

2012

Current Opinion in Pulmonary Medicine

View full text Add to dashboard Cite

Purpose of the review To critically assess recently published literature on predicting asthma exacerbations in children, while also providing general recommendations for future research in this field. Recent findings Current evidence suggests that every effort should be made to provide optimal treatment to achieve adequate asthma control, as this will significantly reduce the risk of severe disease exacerbations. Children who have had at least one asthma exacerbation in the previous year are at highest risk for subsequent exacerbations, regardless of disease severity and/or control. Although several tools and biomarkers to predict asthma exacerbations have been recently developed, these approaches need further validation and/or have only had partial success in identifying children at risk. Summary Although considerable progress has been made, much remains to be done. Future studies should clearly differentiate severe asthma exacerbations due to inadequate asthma control from those occurring in children whose asthma is well controlled, utilize standardized definitions of asthma exacerbations, and use a systematic approach to identify the best predictors after accounting for the multiple dimensions of the problem. Our ability to correctly predict the development of severe asthma exacerbations in an individual child should improve in parallel with increased knowledge and/or understanding of the complex interactions among genetic, environmental (e.g., viral infections) and lifestyle (e.g., adherence to treatment) factors underlying these events.

show abstract

Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin‐8 release

Abstract: HRV and enzymatically active Der p I can act synergistically in the induction of bronchial epithelial IL-8 release, when HRV infection precedes or is concurrent with Der p I exposure. Such a synergy may represent an important mechanism in virus-induced asthma exacerbations.

Cited by 47 publications

References 61 publications

A chest physician's guide to mechanisms of sinonasal disease

A chest physician's guide to mechanisms of sinonasal disease

Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses

Predicting asthma exacerbations in children

Contact Info

Product

Resources

About