Rhinosporidiosis: Three Domestic Cases

Gaines, Joseph J.; Clay, J. R.; Chandler, Francis W.; Powell, M.E.A.; Sheffield, P. A.; Keller, Annie

doi:10.1097/00007611-199601000-00011

Cited by 21 publications

(4 citation statements)

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“…Rhinosporidioisis appears to be endemic in the Indian subcontinent (54,199,258,352), but significant numbers of cases have also been reported from Malawi and Kenya (295), northern Serbia (413), Zaire (397), Kuwait (371), and the United States of America (108,169,321). The prevalence of this condition in a south Indian village was reported to be 470 per 100,000 population (61).…”

Section: Mycotic Conjunctivitismentioning

confidence: 99%

“…Ocular lesions are supposedly more frequent in Sri Lanka than in India, especially in Sinhalese women (226); however, no explanation has been given for this observation. Ocular rhinosporidiosis most frequently involves the palpebral conjunctiva; conjunctival growths are pink or red, granular, or lobulated (occasionally flattened); they may be sessile or stalked and are attached to the upper or lower fornix or tarsal conjunctiva (108,295,321,352,397). Conjunctival rhinosporidiosis with associated scleral melting and staphyloma formation, a rare occurrence, has recently been found in three Indian patients (54); the lesions presented as grey-white spherules without polyps.…”

Section: Mycotic Conjunctivitismentioning

confidence: 99%

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Current Perspectives on Ophthalmic Mycoses

2003

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Fungi may infect the cornea, orbit and other ocular structures. Species of Fusarium, Aspergillus, Candida, dematiaceous fungi, and Scedosporium predominate. Diagnosis is aided by recognition of typical clinical features and by direct microscopic detection of fungi in scrapes, biopsy specimens, and other samples. Culture confirms the diagnosis. Histopathological, immunohistochemical, or DNA-based tests may also be needed. Pathogenesis involves agent (invasiveness, toxigenicity) and host factors. Specific antifungal therapy is instituted as soon as the diagnosis is made. Amphotericin B by various routes is the mainstay of treatment for life-threatening and severe ophthalmic mycoses. Topical natamycin is usually the first choice for filamentous fungal keratitis, and topical amphotericin B is the first choice for yeast keratitis. Increasingly, the triazoles itraconazole and fluconazole are being evaluated as therapeutic options in ophthalmic mycoses. Medical therapy alone does not usually suffice for invasive fungal orbital infections, scleritis, and keratitis due to Fusarium spp., Lasiodiplodia theobromae, and Pythium insidiosum. Surgical debridement is essential in orbital infections, while various surgical procedures may be required for other infections not responding to medical therapy. Corticosteroids are contraindicated in most ophthalmic mycoses; therefore, other methods are being sought to control inflammatory tissue damage. Fungal infections following ophthalmic surgical procedures, in patients with AIDS, and due to use of various ocular biomaterials are unique subsets of ophthalmic mycoses. Future research needs to focus on the development of rapid, species-specific diagnostic aids, broad-spectrum fungicidal compounds that are active by various routes, and therapeutic modalities which curtail the harmful effects of fungus- and host tissue-derived factors

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Section: Mycotic Conjunctivitismentioning

confidence: 99%

Section: Mycotic Conjunctivitismentioning

confidence: 99%

Current Perspectives on Ophthalmic Mycoses

2003

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“…Rhinosporidium seeberi is the etiologic agent of rhinosporidiosis, a granulomatous disease that causes polypoidal masses in mucous membranes and skin of human beings,1,2 other mammals,3–12 and birds 13–15. The disease is endemic in the tropics, as well as in southern India and Sri Lanka, and has been reported in the Americas, Europe, Africa, and Asia 16.…”

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confidence: 99%

Cytologic identification of immature endospores in a dog with rhinosporidiosis

Meier

Meinkoth

Brunker

et al. 2006

Veterinary Clinical Pathol

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An 8-year-old, intact, male Labrador Retriever was presented to the Boren Veterinary Medical Teaching Hospital at Oklahoma State University with a 2-month history of severe sneezing episodes that resulted in epistaxis and bilateral sanguineous discharge. Rhinoscopy revealed a small polypoid mass, and specimens were obtained for histopathology. Microscopic examination of formalin-fixed tissue specimens revealed organisms consistent with Rhinosporidium seeberi. The mass was surgically excised and impression smears were made for cytology examination. Smears revealed high numbers of endospores, typical of those previously described for R seeberi. In addition, numerous smaller structures, presumed to be immature endospores, were noted. The immature endospores were morphologically distinct from mature endospores and have not been described previously. Recognition of immature forms of Rhinosporidium may help prevent misidentification of the organism or misdiagnosis of a dual infection.

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“…The vast majority of rhinosporidiosis cases have been reported from India, Pakistan and Sri Lanka. 1 In North and South America, including Colombia, cases have been reported from 12 countries, 10,30–61 but only Paraguay and north-eastern Brazil are considered endemic areas. 46,59…”

Section: Discussionmentioning

confidence: 99%

Rhinosporidiosis in Colombia: case series and literature review

Vélez

Jiménez²,

Hidrón

et al. 2018

Trop Doct

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Rhinosporidiosis is a chronic granulomatous disease that affects mucosal surfaces. Its epidemiology and clinical presentation in Colombia are not well-known. We therefore reviewed all 58 reported cases between 1964 and 2015 to raise awareness among clinicians in a non-endemic area. Of the patients, 64% were male (median age = 15 years) and 57% had ocular and 43% nasal manifestations; there were no disseminated cases of the disease. All lesions were surgically removed.

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Rhinosporidiosis: Three Domestic Cases

Cited by 21 publications

References 0 publications

Current Perspectives on Ophthalmic Mycoses

Current Perspectives on Ophthalmic Mycoses

Cytologic identification of immature endospores in a dog with rhinosporidiosis

Rhinosporidiosis in Colombia: case series and literature review

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