2003
DOI: 10.1128/cmr.16.4.730-797.2003
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Current Perspectives on Ophthalmic Mycoses

Abstract: Fungi may infect the cornea, orbit and other ocular structures. Species of Fusarium, Aspergillus, Candida, dematiaceous fungi, and Scedosporium predominate. Diagnosis is aided by recognition of typical clinical features and by direct microscopic detection of fungi in scrapes, biopsy specimens, and other samples. Culture confirms the diagnosis. Histopathological, immunohistochemical, or DNA-based tests may also be needed. Pathogenesis involves agent (invasiveness, toxigenicity) and host factors. Specifi… Show more

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Cited by 400 publications
(414 citation statements)
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“…The use of corticosteroids, ocular surgery, ocular surface disease and contact lens wear has now also been increasingly identified as a significant risk factor. Conversely, C. albicans and related fungi are only linked to keratitis when there is a pre-existing ocular condition like insufficient tear secretion, defective eye closure, or some systemic illness such as diabetes mellitus or immunosuppression [195]. This form of keratomycosis may also supervene on a pre-existing epithelial defect caused by herpes keratitis or abrasion due to contaminated contact lenses.…”
Section: Mycotic Keratitismentioning
confidence: 99%
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“…The use of corticosteroids, ocular surgery, ocular surface disease and contact lens wear has now also been increasingly identified as a significant risk factor. Conversely, C. albicans and related fungi are only linked to keratitis when there is a pre-existing ocular condition like insufficient tear secretion, defective eye closure, or some systemic illness such as diabetes mellitus or immunosuppression [195]. This form of keratomycosis may also supervene on a pre-existing epithelial defect caused by herpes keratitis or abrasion due to contaminated contact lenses.…”
Section: Mycotic Keratitismentioning
confidence: 99%
“…Fungal pathogens display a variety of adhesins that are capable of adhering to various cell types and interact with a variety of host proteins and glycoproteins present in host cells [68]. The outer fibrillar layer of yeast and filamentous fungal cell wall is composed of mannan or mannoprotein [75,195]. The adhesive mannoproteins play an essential role in fungal binding to corneal tissues.…”
Section: Adhesionmentioning
confidence: 99%
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“…As infecções oculares fúngicas vêm sendo cada vez mais reconhecidas como uma importante causa de morbidade e cegueira (6) . Os fungos são agentes oportunistas no olho, uma vez que raramente infectam olhos sadios ou que apresentem sua estrutura íntegra.…”
Section: Discussionunclassified