Rhinomucormycosis

Berk, Morris

doi:10.1001/jama.1961.73040330024011b

Cited by 25 publications

(1 citation statement)

References 3 publications

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“…From an ophthalmological viewpoint the most common feature in mucormycosis is an orbital cellulitis. Many cases of this have been reported (Gregory et al, 1943;LeCompte and Meissmer, 1947;Stone, 1950;Martin et al, 1954;Bauer et al, 1955;Harris, 1955;Foushee and Beck, 1956;Johnson, 1956;Baker, 1957;McCall and Strobos, 1957;Bryan et al, 1958;Dwyer and Changus, 1958;Borland, 1959;Burns, 1959;Dolman and Herd, 1959;Faillo et al, 1959;Hutter, 1959;Long and Weiss, 1959;Berk, 1961;Ferry, 1961;Gass, 1961a;Gass, 1961b;Hoagland et al, 1961;Rabin et al, 1961;Wasserman et al, 1961;Bank et al, 1962;Straatsma et al, 1962;Lubbe, 1964;Lincoff et al, 1965;Parmentier et al, 1965;Ginsberg et al, 1966;Tomiyashu and Baker, 1966;Baum, 1967;Blodi et al, 1969;Fleckner and Ginsberg, 1969;Anco and Iriya, 1970;Best et al, 1971;Vergez et al, 1971;Georgiades et al, 1972;Bullock et al, 1974). Intraocular involvement in mucormycosis, diagnosed by the...…”

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confidence: 99%

Orbitofacial mucormycosis with unusual pathological features.

Albert¹,

Lesser²,

Cykiert³

et al. 1979

British Journal of Ophthalmology

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SUMMARY A 52-year-old man with mild diabetes and acute stem cell leukaemia developed an orbitofacial mucormycosis. Cultures showed the fungus to be Rhizopus oryzae. Vigorous treatment with amphotericin B and with other bactericidal and bacteriostatic antibiotics for a concurrent sepsis failed to suppress the infections, and the patient died. On post-mortem examination characteristic haematoxylin-staining, broad, aseptate fungal hyphae were found in the right eye, orbit, and lung. A striking and unusual feature of this case is the presence of brightly biiefringent crystals within the severely degenerated eye. These were found by histochemical staining and x-ray diffraction studies to be calcium salts of fatty acids, apparently liberated from necrotic adipose tissue of the orbit.Mucormycosis, or phycomycosis, is an infection caused by one of a variety of fungi belonging to the class Phycomycetes. Although these fungi are usually saprophytic and ubiquitous in nature, they can cause serious and rapidly fatal infections in man. Usually the patients who manifest this infection have a predisposing debilitating condition, among the most common of which are diabetes with acidosis, diarrhoea and dehydration, renal failure, cirrhosis, leukaemia or other lymphoproliferative disorders, and severe burns. In addition steroids, antibiotics, and cytotoxic agents have been strongly implicated both clinically and experimentally as predisposing agents for this infection. Excellent reviews of this subject are available (Hutter, 1959;McBride et al.,

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