Cephalic Mucormycosis (Phycomycosis)

Rhinocerebral Phycomycosis

“…The otolaryngologist should become aware of this entity since it (1) is becoming more frequent, (2) may closely resemble acute sinusitis, (3) is associated with an extremely high mortality, (4) has clinical findings permitting early diagnosis which is essential if these patients are to survive, and (5) has been shown to susceptible to a specific therapeutic aSenl. The otolaryngologist should become aware of this entity since it (1) is becoming more frequent, (2) may closely resemble acute sinusitis, (3) is associated with an extremely high mortality, (4) has clinical findings permitting early diagnosis which is essential if these patients are to survive, and (5) has been shown to susceptible to a specific therapeutic aSenl.…”

Rhinocerebral Mucormycosis

“…The innoculum was deliveredintranasally as a saline suspension that invaded nasal mucosa and pro¬ gressed to the orbit and brain.Nondiabetic animals sustained a local acute inflammatory reaction without invasion of tissue. Studies byBaker,'3 Elder and Baker,1" and Schofield and Baker17 yielded similar results in acidotic rabbits infected by intrathecal injection of Rhizopus as com¬ pared with nonacidotic controls. They also demonstrated increased fungal pathogenicity in animals pretreated death ensue.…”

Rhinocerebral Mucormycosis and Juvenile Diabetes Mellitus: Report of a Case with Recovery

“…These findings in a compromised patient, especially diabetes with acidosis, suggest the diagnosis of rhinocerebral mucormycosis. l>2>4 ' 5 X-ray findings revealed a nodular thickening of the soft tissue lining of the involved sinuses with spotty destruction of the walls of the sinuses. Focal bone destruction is a hallmark of this disease.…”