Rhinocerebral mucormycosis: report of a rare case

Sahota, Richa; Gambhir, Ramandeep Singh; Anand, Smriti; Dixit, Avani

doi:10.4314/ejhs.v27i1.11

Cited by 27 publications

(34 citation statements)

References 15 publications

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“…It predominantly affects immunocompromised hosts and is associated with a spectrum of disease. [ 1 ] It is a potentially lethal infection caused primarily by filamentous fungus Rhizopus, Mucor and Lichtheimia species of the fungi of the order Mucorales . [ 2 ] An ulcer or a dental extraction in the mouth can be the port of fungal invasion.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] An ulcer or a dental extraction in the mouth can be the port of fungal invasion. [ 1 3 ] Risk factors for invasive mucormycosis include a high dose of glucocorticoid therapy, long-term neutropenia, intravenous drug use, malnutrition, stem cell or solid organ transplantation, treatment with deferoxamine and severe skin damages such as burns and surgical suture sites. [ 2 3 4 ] Diagnosis is usually made by clinical suspicion and histopathological examination.…”

Section: Introductionmentioning

confidence: 99%

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Mucormycosis in immunocompetent patient resulting in extensive maxillary sequestration

Venkatesh¹,

Dandagi

Chandrappa³

et al. 2018

J Oral Maxillofac Pathol

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Mucormycosis or zygomycosis, also called phycomycosis, is an uncommon, invasive, potentially lethal and an aggressive fungal infection of the order Mucorales that usually affects patients with alteration of their immunological system. From its initial description (Paltauf, 1885), this entity still has a high mortality. Imaging techniques are not usually diagnostic, and cultures are not totally reliable. Definitive diagnosis is exclusively obtained by means of histopathological examination. Early recognition and aggressive treatment are of paramount importance and have reduced the mortality and morbidity. We present here a case report of oral mucormycosis in a 32-year-old male, immunocompetent individual resulting in extensive maxillary sequestration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mucormycosis in immunocompetent patient resulting in extensive maxillary sequestration

Venkatesh¹,

Dandagi

Chandrappa³

et al. 2018

J Oral Maxillofac Pathol

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show abstract

“…The underlying diseases for mucormycosis include uncontrolled diabetes, organ transplant, malignancies such as lymphoma and leukemia, immunosuppressive therapy, renal failure, and acquired immune deficiency syndrome (AIDS). [2] The unique point of our case is that mucormycosis occurred after FESS. It is common to use antibiotics after FESS and oral or topical steroids may be used to reduce edema intermittently.…”

Section: Discussionmentioning

confidence: 92%

“…[1] It usually occurs in patients with metabolic abnormalities or who are immunocompromised with prolonged neutropenia. [2] However, it can also occur in patients without any underlying disease process. Patients without any underlying disease process have a 25% mortality versus 40 and 80% mortality for patients with metabolic abnormalities and immunocompromised patients, respectively.…”

Section: Introductionmentioning

confidence: 99%

Rhinocerebral mucormycosis after functional endoscopic sinus surgery

Yeo¹,

Kim

Kwon

et al. 2018

Medicine

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Rationale:Mucormycosis is a rare fungal infection which mainly develops in compromised hosts and the associated mortality rate is high.Patient concerns:We report a case of mucormycosis in a 59-year-old woman following routine endoscopic sinus surgery. The patient had a history of diabetes mellitus (DM) and bronchial asthma.Diagnoses:On follow-up 4 weeks after the first functional endoscopic sinus surgery (FESS), she complained of a severe headache and was readmitted for a second period. Endoscopic examination revealed bony erosion and a whitish discharge on the left middle turbinate, which was confirmed as mucormycosis by endoscopic biopsy.Interventions:Endoscopic debridement of the necrotic tissue and middle turbinectomy were performed and the patient was treated with intravenous amphotericin B for 3 months (3.5 mg/kg/day).Outcomes:About 1 month into the second period of hospitalization, left Bell's palsy had occurred. The facial palsy improved naturally after 2 months of hospitalization. One year after endoscopic debridement, follow-up endoscopy showed that there was no residual lesion.Conclusion:This is the first report of mucormycosis after routine endoscopic sinus surgery. We did not miss headache symptom after FESS surgery, and diagnosed mucormycosis through early endoscopic biopsy, which played an important role in curing the patient. In addition to the importance of medical therapy such as DM control for patients, emotional support and psychiatric treatment are also important factors as these patients require hospitalization for a long period, 3 months in the case of this patient.

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“…Mucormycosis can invade different organs and organ systems ( Table 1). The sites of infection include the lung, central nervous system, paranasal sinuses, gastrointestinal system, or even skin and subcutaneous tissues in the case of subcutaneous mycoses (Castrejón-Pérez et al, 2017;Lin et al, 2017;Sahota et al, 2017). Its clinical manifestations are varied but characteristically demonstrate rapid progression (Skiada et al, 2018).…”

Section: Mucormycosismentioning

confidence: 99%

A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses

et al. 2021

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After cardiovascular diseases, infectious diseases are the second most common cause of death worldwide. Although these infections are caused mainly by viruses or bacteria, a systematically growing prevalence of human and animal opportunistic fungal infections is noticeable worldwide. More attention is being paid to this problem, especially due to the growing frequency of recalcitrant and recurrent mycoses. The latter are classically divided into superficial, which are the most common type, subcutaneous, and systemic. This work discusses opportunistic fungal pathogens without proven horizontal transmission between different animal species including humans and microsporidia as spore-forming unicellular parasites related to fungi; however, with a yet undetermined taxonomic position. The review also mentions etiological agents, risk factors, epidemiology, geographical distribution, and finally symptoms characteristic for individual disease entities. This paper provides insight into fungal infections from a global perspective and Accepted Article This article is protected by copyright. All rights reserved simultaneously draws attention to emerging pathogens, whose prevalence is continuously increasing. Finally, this work also takes into consideration the correct nomenclature of fungal disease entities and the importance of secondary metabolites in the pathogenesis of fungal infections.

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Rhinocerebral mucormycosis: report of a rare case

Cited by 27 publications

References 15 publications

Mucormycosis in immunocompetent patient resulting in extensive maxillary sequestration

Mucormycosis in immunocompetent patient resulting in extensive maxillary sequestration

Rhinocerebral mucormycosis after functional endoscopic sinus surgery

A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses

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