Rhinocerebral mucormycosis: a devastating rhinological condition

Grant, Paul; Skilbeck, Christopher J.

doi:10.1002/pdi.1826

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…Thickened mucosal lining, opacification of the paranasal sinuses, and obliteration of ostiomeatal complex are the principal radiographic findings concerning the sinuses during mucormycosis by CT scan (100% in the present series). Also, CT scanning may reveal fluid levels, bone destruction, and osteomyelitis [ 27 , 51 ]. However, radiological findings may be non-specific initially thus serial radiological investigations are required to assess progression and extent [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

et al. 2021

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“…CT scanning provides evidence for the thickening of the mucosa and turbidity in the sinuses. Infection spread to the orbit and cranial area can be evaluated by magnetic resonance imaging (MRI) [ 64 ]. Opacification of the paranasal sinuses is the principal radiographic finding concerning the sinuses during mucor-mycosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical features, diagnosis, and outcomes of rhino-orbito-cerebral mucormycosis: A retrospective analysis

et al. 2016

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Background and Purpose:Rhino-orbito-cerebral mucormycosis (ROCM) is a rare disease with acute and fulminant manifestation. This infection is associated with high morbidity and mortality rates. Herein, we reviewed the manifestations, underlying conditions, medical treatments, and surgical interventions in ROCM patients admitted to a tertiary referral center in northern Iran over a seven-year period.Materials and Methods:In a retrospective analysis, 15 cases of ROCM were identified from 2007 to 2013 in Bu Ali Sina Hospital, Sari, Iran. All the ROCM cases were clinically diagnosed and confirmed by histopathological and/or mycological examination. The relevant demographic data, clinical, ophthalmic, and neurologic manifestations, underlying conditions, medical treatments, and surgical interventions were recorded and analyzed.Results:The mean age of the patients was 54±11 years (age range: 28–70 years); 26.7% of the patients were male and 73.3% female (male: female ratio of 1: 2.7). Uncontrolled diabetes was noted in at least 86.7% (13/15) of the cases. The maxillary sinuses were the most frequently involved sites (66.7% of the cases) followed by the ethmoid sinus. Amphotericin B in combination with surgical debridement was used in the treatment of 80% of the cases. Furthermore, 73.3% of the patients who were diagnosed early and underwent medical and extensive surgical debridement of the infected tissues survived.Conclusion:Uncontrolled diabetes mellitus is considered to be the main predisposing factor for ROCM. To prevent and reduce mortality rate of this acute disease, early diagnosis based on clinical findings and biopsy is recommended.

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“…3 MRI is the preferred imaging modality for orbital disease and is useful in determining the extent of intracranial involvement. 10 When MRI does not show a definitive abnormality, diffusion-weighted imaging (DWI) plays an important role in demonstrating optic nerve thickening and infarction. Ischemic optic nerve involvement manifests as high signal intensity along the nerve on DWI and a hypointense signal on apparent diffusion coefficient determination.…”

Section: Discussionmentioning

confidence: 99%

“…This involves discontinuation of immuno suppressants in iatrogenic cases and optimization of blood glucose and electrolyte disturbances in diabetic patients. 10…”

Section: Discussionmentioning

confidence: 99%

Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma

Beketova

Bailey

Crowell

et al. 2018

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A 61-year-old man with well-controlled diabetes mellitus type 2, cirrhosis from hepatitis C, alcohol abuse, and portal hypertension presented with painful vision loss and left orbital swelling. Imaging showed diffuse orbital, perineural, and pachymeningeal inflammation. He was initially diagnosed with neurosarcoidosis. However, cerebrospinal fluid analysis revealed central nervous system lymphoma, and lacrimal gland biopsy showed fungal organisms consistent with mucormycosis. We describe a case of Mucorales infection lacking sinonasal involvement and discuss the differential diagnosis and management of patients presenting with orbital and central nervous system inflammation from this uncommon fungal infection.

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Rhinocerebral mucormycosis: a devastating rhinological condition

Abstract: Mucormycosis is an unusual but serious fungal infection that most commonly affects people with diabetes mellitus. A defining characteristic is the rapidity at which it develops and the devastation which it can cause. Copyright © 2014 John Wiley & Sons.

Cited by 8 publications

References 19 publications

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

Clinical features, diagnosis, and outcomes of rhino-orbito-cerebral mucormycosis: A retrospective analysis

Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma

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