Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma

Abstract

A 61-year-old man with well-controlled diabetes mellitus type 2, cirrhosis from hepatitis C, alcohol abuse, and portal hypertension presented with painful vision loss and left orbital swelling. Imaging showed diffuse orbital, perineural, and pachymeningeal inflammation. He was initially diagnosed with neurosarcoidosis. However, cerebrospinal fluid analysis revealed central nervous system lymphoma, and lacrimal gland biopsy showed fungal organisms consistent with mucormycosis. We describe a case of Mucorales infection lacking sinonasal involvement and discuss the differential diagnosis and management of patients presenting with orbital and central nervous system inflammation from this uncommon fungal infection.

Characterizing patients with rare mucormycosis infections using real-world data

“…The most common non-HM comorbidity in patients with HM and IM was essential primary hypertension (50.31% of patients), which seemed to be a unique finding compared with pooled data studies, although this could be because there was a large proportion of patients with hypertension in the overall HM cohort, and a large proportion of patients of ≥ 65 years of age. Interestingly, however, a history of hypertension has been observed in some individual case studies of patients with IM, suggesting a potential association between hypertension and IM that has not been reported in a larger patient population [ 26 – 28 ]. Additional research into these findings could help to further our understanding of the potential predictors of IM in patients with HM.…”