Rhino-orbital mucormycosis—A case report

Yadav, Sakshi; Goel, Anuj Kumar

doi:10.1016/j.pedex.2008.12.008

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…The standard medical therapy is Amphothericin B in a dose of 1-1.5 mg/kg/day for several weeks based on the clinical response and degree of nephrotoxicity. [ 13 ] Lipid formulation of amphothericin B can be used at higher doses and for a longer time than amphothericin B due to its reduced nephrotoxicity. [ 14 ] As pterygopalatine fossa is considered to be a reservoir of the fungus debridement of the pterygopalatine fossa seems to be the definitive method of managing this infection.…”

Section: Discussionmentioning

confidence: 99%

Facial nerve paralysis: A case report of rare complication in uncontrolled diabetic patient with mucormycosis

Shekar¹,

Sikander²,

Rangdhol³

et al. 2015

J Nat Sc Biol Med

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Mucormycosis is a rare opportunistic aggressive and fatal infection caused by mucor fungus. Seven types of mucormycosis are identified based on the extension and involvement of the lesion, of which the rhino orbital mucormycosis is most common in the head and neck region. Although it is widely spread in nature, clinical cases are rare and observed only in immunocompromised patients and patients with uncontrolled diabetes mellitus. Early symptoms include fever, nasal ulceration or necrosis, periorbital edema or facial swelling, paresthesia and reduced vision. Involvement of cranial nerves although not common, facial nerve palsy is a rare finding. The infection may spread through cribriform plate to the brain resulting in extensive cerebellar infarctions. Timely diagnosis and early recognition of the signs and symptoms, correction of underlying medical disorders, and aggressive medical and surgical intervention are necessary for successful therapeutic outcome.

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Section: Discussionmentioning

confidence: 99%

Facial nerve paralysis: A case report of rare complication in uncontrolled diabetic patient with mucormycosis

Shekar¹,

Sikander²,

Rangdhol³

et al. 2015

J Nat Sc Biol Med

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“…Nonetheless, combined medical and surgical treatment increases the survival rate from 57.5% to 78%, compared to the medical management alone (18,19) . The standard medical therapy for sino-orbital mucormycosis is amphotericin B at 1-1.5 mg/kg/day for several weeks, based on the clinical response and degree of nephrotoxicity (20) . Our patient was initially scheduled for endoscopic sinus surgery and orbital decompression.…”

Section: Fig 2 Axial Ct Of Pns Showing Mucosal Thickening and Granuloma In Maxillary Sinus With Medial Wall Erosion (A) And Mass Extendinmentioning

confidence: 99%

Facial nerve palsy as an unusual presentation of orbital apex syndrome

R¹,

Yu²,

Giap³

et al. 2021

Pediatr Med Rodz

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Clinical cases of orbital apex syndrome are rare and most commonly manifested as a complication of fungal sinusitis, mainly in immunocompromised and poorly controlled diabetic patients. Rhino-orbital mucormycosis is a rare opportunistic, aggressive and fatal infection caused by mucor. The complex presentation of orbital apex syndrome not only poses a diagnostic challenge but also demands a multidisciplinary approach in patient management. Facial nerve palsy is an unusual presentation in orbital apex syndrome. We report the case of a 64-year-old diabetic patient presenting with ophthalmoplegia and visual loss associated with facial nerve palsy. Prompt ophthalmologic and otolaryngologic intervention with imaging and histologic confirmation, followed by early initiation of antifungal and antimicrobial therapy, were integral to preventing further complications, and reducing morbidity and mortality.

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“…2 Mucormycosis most commonly affects the nasal mucosa, but it can also invade the sinuses, orbits, and brain. 3 ROCM typically progresses in three stages: Stage I involves an infection of the nasal mucosa and paranasal sinuses; Stage II involves involvement of the orbits; and Stage III involves involvement of the brain, which primarily affects people with metabolic or immunological compromise. 4 Patients with rhino-orbito-cerebral mucormycosis present with pain and paresthesia in their faces, headaches, swollen orbits and noses, inflammation, drooping eyelids, proptosis, external and internal ophthalmoplegia, vision loss, and blackish necrosis of the palate and nasal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Rhino-Orbital Cerebral Mucormycosis in a Healthy Female Child: Case Report

Yusuf,

Ibrahim,

Hirsi

et al. 2024

IMCRJ

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Mucormycosis is a potentially fatal condition with a high mortality rate, particularly when there is extra nasal involvement, and it is rare for patients with fungal brain disease to survive. It mostly affects patients who are metabolically or immunologically compromised, which constitutes one of the three classical stages of the progression of Rhino-Orbito-Cerebral Mucormycosis (ROCM). Stage I: infection of the nasal mucosa and paranasal sinuses; Stage II: orbital involvement; Stage III: cerebral involvement.Here, we report a case of rhino-orbital cerebral mucormycosis in a 14-year-old girl with no known risk factor who presented with periorbital edema, right eye proptosis, fever, and extreme facial pain, which progressively worsened to confusion and left leg weakness in 3 days after admission. The final diagnosis was rhino-orbital-cerebral mucormycosis. The infection was successfully treated using liposomal amphotericin and surgical debridement to remove infected orbital tissue. Mucormycosis is a potentially fatal disease that necessitates prompt diagnosis and treatment. Children are rarely infected with mucormycosis. The majority of studies show that people are typically between 40 and 50 years old. ROCM is typically diagnosed using clinical symptoms and histopathologic evaluation; however, imaging is critical in determining the presence of intracranial lesions. The standard treatment for ROCM is amphotericin B at a recommended dose of 1.0-1.5 mg/kg/day for weeks or months, depending on the clinical response and severity of adverse drug reactions, particularly nephrotoxicity.Rhino-orbital cerebral mucormycosis in a healthy female child is uncommon; early diagnosis and prompt treatment with Amphotericin B should be necessary. Devastating consequences will result from a delayed diagnosis.

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Rhino-orbital mucormycosis—A case report

Cited by 7 publications

References 15 publications

Facial nerve paralysis: A case report of rare complication in uncontrolled diabetic patient with mucormycosis

Facial nerve paralysis: A case report of rare complication in uncontrolled diabetic patient with mucormycosis

Facial nerve palsy as an unusual presentation of orbital apex syndrome

Rhino-Orbital Cerebral Mucormycosis in a Healthy Female Child: Case Report

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