Rheumatoid Syndrome Associated with Lung Interstitial Disorder in a Dental Technician Exposed to Ceramic Silica Dust. A Case Report and Critical Literature Review

Iannello, Silvia; Camuto, Massimo; Cantarella, Salvatore; Cavaleri, Antonina; Ferriero, P.; Leanza, Antonio; Milazzo, Paolina; Belfiore, Francesco

doi:10.1007/s100670200019

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…The immunological features of patients with SIL , who have been exposed to silica but not to asbe stos , have been investigated clinically and experimentally because ofthe frequent complications ofautoimmune diseases (19)(20)(21). We have been focusing on the Fas-mediated apoptotic pathway in lymphocytes (22)(23)(24) and also on various autoantibodies (25)(26)(27) in SIL patients and have reported that Fas-mediated apoptosis is impaired in SIL patients.…”

Section: Tcr-vj3 Analyses Of Silica and Asbestos-related Disordersmentioning

confidence: 99%

Expression of the T Cell Receptor Vβ Repertoire in a Human T Cell Resistant to Asbestos-Induced Apoptosis and Peripheral Blood T Cells from Patients with Silica and Asbestos-Related Diseases

Nishimura

Miura

Maeda

et al. 2006

Int J Immunopathol Pharmacol

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To explore the effects of asbestos and silica on the human immune system, an experimental model of lowdose and long-term exposure was established using a human UTLV-l-immortalized polyclonal T cell line, MT-2 (MT-20rg). MT-2 cells were continuously exposed to asbestos at a concentration (10 ug/ml) which does not induce complete cell death during short-term exposure. After acquiring resistance to CD-induced apoptosis (designated MT-2Rst), an immunological comparison was made between the MT-20rg and MT2Rst lines in terms of T cell receptor-VO (TcR-VO) expression. MT-2Rst cells showed excess expression of various TcR-VO, although TcR-VO-overpresenting cells were characterized as undergoing apoptosis due to first contact with CD. Patients with asbestos-related diseases (AJ{D), such as asbestosis and malignant mesothelioma, were compared with silicosis (SIL) patients as a disease control and with healthy donors (UD). SIL and ARD not only differed in their causative materials, silica and asbestos as mineral silicates, but also in terms of complications; autoimmune disorders in SIL and tumors in ARD. ARD patients showed a restricted overpresentation ofTcR-VO without clonal expansion, whereas SIL patients revealed significant overpresentation of TcR-VO 7.2. These experimental and clinical analyses indicate the superantigenic and dysregulation of autoimmunity-inducing effects of asbestos and silica, respectively.Asbestos (e.g. chrysotile, crocidolite and amosite) is known to cause malignant lung cancer or mesothelioma. The International Agency for Research on Cancer (IARC) categorizes both asbestos and crystalline silica as group I carcinogens (1). According to the IARC classification, asbestos affects alveolar epithelial and mesothelial cells. There have been many studies concerning asbestosinduced apoptosis in these cells. Experimentally, these cells have undergone apoptosis on a relatively high-level, short-term exposure to asbestos via the production of ROS and RNS with activation of the mitochondrial apoptotic pathway (2-4). Thus, it has been considered that during low-level and long-term exposure to asbestos in the human body, alveolar epithelial and mesothelial cells escape from

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Section: Tcr-vj3 Analyses Of Silica and Asbestos-related Disordersmentioning

confidence: 99%

Expression of the T Cell Receptor Vβ Repertoire in a Human T Cell Resistant to Asbestos-Induced Apoptosis and Peripheral Blood T Cells from Patients with Silica and Asbestos-Related Diseases

Nishimura

Miura

Maeda

et al. 2006

Int J Immunopathol Pharmacol

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“…In this study, to elucidate the role of Treg in silicosis patients, the frequency in peripheral blood and function of Treg were examined, since silicosis may be the pre-clinical status for autoimmune diseases (1)(2)(3)(4). In addition, our previous results indicated that in silicosis patients, who did not manifest clinical signs and symptoms of autoimmune diseases, possessed the dysregulation of Fas-mediated apoptotic pathway in their lymphocytes and was disrupted (5)(6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

Reduced Function of CD4+25+ Regulatory T Cell Fraction in Silicosis Patients

Wu¹,

Miura²,

Hyodoh³

et al. 2006

Int J Immunopathol Pharmacol

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The quality and quantity of CD4+25+ regulatory T cells (Treg) in silicosis patients (SIL) were examined and' compared with results from healthy donors (HD) because SIL often develop autoimmune diseases along with pulmonary disorders. Peripheral blood mononuclear cells from 57 SIL and 50 HD were analyzed for Treg. Treg frequency and clinical parameters were subjected to a factor analysis. Treg and CD4+25-T cells (Tneg) from five HD and five SIL, sorted by flow-cytometer, were used for functional assays of Treg, the expression pattern of Treg specific genes (FoxP3, GITR and CTLA-4) and activation-related genes (CD122 and CD123). Although the actual frequency of Treg did not differ between SIL and HD, the age-corrected level was reduced in SIL. The factor analysis showed that Treg frequency was positively associated with the serum level of IL-2. The inhibitory effect of Treg on Tneg activation was decreased when the Treg:Tneg ratio was 1:

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“…The most common finding in DTP patients is round nodules on HRCT (5). Studies have reported radiologic abnormalities such as diffuse reticulonodular infiltration, calcified lymph nodes, small opacities (International Labour Organization [ILO] category ≥1/0), and diffuse interstitial disorder in DTP; however, this is the first report of conglomerated lymphadenopathy and increased PET uptake (1,2,7,8).…”

Section: Discussionmentioning

confidence: 79%