Reduced Function of CD4+25+ Regulatory T Cell Fraction in Silicosis Patients

Wu, Ping; Miura, Yoshie; Hyodoh, Fuminori; Nishimura, Yasumasa; Hatayama, Tamayo; Hatada, Satomi; Sakaguchi, Haruko; Kusaka, Masayasu; Katsuyama, Hironobu; Tomita, Masafumi; Otsuki, Takemi

doi:10.1177/039463200601900212

Cited by 48 publications

(45 citation statements)

References 46 publications

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“…3-B and 3-C, the CD4+25+ fraction from SILs lost the dominant expression levels of both genes. These results suggested the CD4+25+ fraction in SILs was contaminated with chronically activated Tresp by exposure to silica Wu, 2006). As expected and shown in Fig.…”

Section: Chronic Activation Of Treg By Exposure To Silicasupporting

confidence: 87%

“…3-D, the percentage of the CD4+25+ fraction in peripheral lymphocytes was significantly smaller in HVs than SILs. Although the CD4+FoxP3+ fraction did not differ between HVs and SILs, the CD25+FoxP3-population was higher in SILs than HVs Wu, 2006). These analyses indicated that the CD4+25+ fractions in SILs were contaminated by chronically activated Tresp due to exposure to silica Wu, 2006).…”

Section: Chronic Activation Of Treg By Exposure To Silicamentioning

confidence: 72%

“…2-C) and several findings demonstrate the chronic and recurrent activation of Tresp in SILs, the peripheral CD4+25+ fraction in SILs may be contaminated by these activated Tresp expressing CD25 on the base of Treg . Thus, we first analyzed the function of the Treg fraction (actually, the peripheral CD4+25+ fraction sorted by flow cytometry in which Treg is mainly included and there is no availability of FoxP3-sorted cells for biological use as mentioned above) (Wu, 2006). As shown in Fig.…”

Section: Chronic Activation Of Treg By Exposure To Silicamentioning

confidence: 99%

See 2 more Smart Citations

Immunological Effects of Silica and Related Dysregulation of Autoimmunity

Kumagai¹,

Hayashi²,

Maeda³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

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Section: Chronic Activation Of Treg By Exposure To Silicasupporting

confidence: 87%

Section: Chronic Activation Of Treg By Exposure To Silicamentioning

confidence: 72%

Section: Chronic Activation Of Treg By Exposure To Silicamentioning

confidence: 99%

See 1 more Smart Citation

Immunological Effects of Silica and Related Dysregulation of Autoimmunity

Kumagai¹,

Hayashi²,

Maeda³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

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“…In addition, the function of this fraction in SILs was less significant than that in HDs, as determined by alloreactive mixed lymphocyte reaction (MLR) analysis (42).…”

Section: Alterations Of Fas-related Molecules and Cd4+25+ Regulatory mentioning

confidence: 95%

Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006)

Otsuki

Miura

Maeda

et al. 2007

Environ Health Prev Med

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Silica and silicates may disturb immune functions such as autoimmunity and tumor immunity, because people who are exposed to the materials sometimes develop autoimmune and malignant diseases, respectively. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica, more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively. In addition, immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies, various cytokines, and molecule-targeting therapies. In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer in 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate the nation wide anxiety about these malignancies.

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“…The trypcanocidal activity of L929 cells was dependent on endogenous nitric oxide synthase activity, which is largely induced by IFN-γ produced by NK cells. Moreover, studies in mice revealed an enhanced cytolytic activity of NK cells as early as 24 hours into T. cruzi infection (9)(10)(11)(12)(13)(14) and direct NK-mediated destruction of the extracellular epimastigote and trypomastigote forms of T. cruzi and T. lewisi in vitro (15)(16)(17).…”

Section: Nk Cells and Parasitesmentioning

confidence: 99%