Rheumatoid Neutrophilic Dermatitis

Interstitial granulomatous dermatitis with arthritis

“…4,9 Granuloma annulare (GA) is a self-limiting, asymptomatic, chronic dermatosis of the dermis that shows papules in an annular arrangement, commonly arising on the dorsum of the hands and feet. Occasionally, it is associated with diabetes and other systemic diseases.…”

A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy

“…[6][7][8][9][10][11][12][13][14][15] RND generally manifests as nontender, erythematous, sometimes urticaria-like, papules, plaques, or nodules, symmetrically distributed on the joints and the extensor surface of the extremities, trunk, and neck. [6][7][8][9][10][11][12][13][14][15] Tiny pustules occasionally also are associated with the condition. 11,12 Lowe et al 9 presented the only report to date of RND displaying vesiculopapular lesions.…”

“…[8][9][10][11][12][13][14][15] Spongiosis, intraepidermal vesiculation, subepidermal edema, and papillary dermal neutrophilic microabscesses also may be present. 9,11,12 Our case manifested with a symmetric eruption of pruritic grouped vesicles and tense bullae on the extremities.…”

“…Other possible treatments include topical steroids, sulfamethoxypyridamine, hydroxychloroquine, colchicine, cyclophosphamide, and etretinate. [6][7][8][9][10][11][12][13][14][15] Considering the role of extremely high RF titer and IgA gammopathy in the patient's condition is interesting. High RF titer frequently is associated with progressive RA and indicates a worse prognosis.…”

“…[2][3][4][5] Recently, a new form of ND, rheumatoid ND (RND), has been reported in patients with severe RA. [6][7][8][9][10][11][12][13][14][15] This article describes a case of RND manifesting mainly with clusters of vesicles and tense bullae, clinically mimicking dermatitis herpetiformis (DH).…”