Interstitial granulomatous dermatitis with arthritis

Altaykan, Aslı

doi:10.1016/j.humpath.2004.04.011

Cited by 24 publications

(26 citation statements)

References 11 publications

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“…15,18,29,30,41 Systemic disorders associated with this condition include drug hypersensitivities, autoimmune connective tissue diseases, and infections, such as hepatitis C. Interestingly, hepatitis B has not been reported. IGD as a paraneoplastic event can be a useful clinical clue to guide further investigation into a difficult clinical complaint.…”

Section: Discussionmentioning

confidence: 99%

A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Cornejo

Lum²,

Izumi³

2013

The American Journal of Dermatopathology

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Cutaneous manifestations associated with myelodysplastic syndromes (MDS) are uncommon and can occur as specific or nonspecific lesions. Recognizing these cutaneous manifestations is important as they can precede blood or bone marrow transformation to leukemia. Granulomatous reactions have rarely been described as nonspecific lesions of MDS. These rare cases histologically resembled granuloma annulare, sarcoid, and a generalized dermal interstitial granulomatous dermatitis (IGD) which were not associated with leukemic infiltration. The authors report an interesting case of an IGD-like eruption evolving over the course of MDS with eventual progression to systemic leukemia. IGD is an inflammatory reaction that refers to a varied spectrum of histologic patterns and is associated with a variety of systemic illnesses and hypersensitivity reactions, including lymphoma and leukemia. In patients with MDS, surveillance for leukemia is a critical component of their follow-up care. Normally, this surveillance occurs through serial peripheral blood smears and bone marrow studies. IGD-like eruptions are a cutaneous reaction pattern that may serve as an additional clinical indicator of leukemic progression in patients with MDS. Although primarily a reactive pattern, this entity can rarely harbor leukemic blasts.

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Section: Discussionmentioning

confidence: 99%

A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Cornejo

Lum²,

Izumi³

2013

The American Journal of Dermatopathology

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“…7-10 Several cases of interstitial granulomatous dermatitis with arthritis were associated with erythematous plaques 7 or with annular plaques. 8,9 A case of interstitial granulomatous dermatitis with arthritis, in which the patient displayed a linear erythematous band (rope sign) with an ANA of 1:160 has also been described. That patient did not have fibrosis affecting the joints.…”

Section: Discussionmentioning

confidence: 99%

A novel case of polyfibromatosis and interstitial granulomatous dermatitis with arthritis

Chen¹,

Chong²,

Green³

et al. 2006

Journal of the American Academy of Dermatology

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“…38 The histiocytes may form small granulomas, and often clusters of histiocytes can rim abnormal collagen and lead to visible clefting, which has been termed the "floating sign," reported in two-thirds of cases. 38 Although rare, eosinophils and neutrophils may be seen, 54 and vasculitis is generally absent in IGD (1 case reported vasculitis, albeit with no histologic image, 36 with more than 35 other reports lacking vasculitis). 38,54 Lymphocytes abutting the epidermis with basal vacuolization are rare, and could represent a distinguishing feature of IGDR differentiating that from pure IGD.…”

Section: Clinical and Histologic Presentationmentioning

confidence: 99%