Rheumatoid factors, anti-filaggrin antibodies and low in vitro interleukin-2 and interferon-γ production are useful immunological markers for early diagnosis of community cases of rheumatoid arthritis. A preliminary study

Vittecoq, Olivier; Jouen-Beades, Fabienne; Krzanowska, Kataryna; Bichon-Tauvel, Isabelle; Ménard, Jean-François; Daragon, A.; Tron, François; Loët, Xavier Le

doi:10.1016/s1297-319x(00)00244-x

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…The association of ACPA and rheumatoid factor (RF)11 42–44 48 50 73 96–110 with a diagnosis of RA at follow-up was compelling in the retrieved literature. The absence of ACPA or RF was diagnostically less helpful.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of ACPA or RF75 106–109 111–115 also increased the probability of developing persistent synovitis or a worse radiographic outcome 73 75 84–86 116. For anti-keratin antibodies (AKA) and anti-perinuclear factor, the evidence suggests diagnostic usefulness; AKA also appears to have some prognostic value 11 96–99 107 110 114 117. For all other markers including a variety of other autoantibodies as well as bone and cartilage biomarkers, the evidence for diagnostic or prognostic value is scarce, negative or controversial 57 102 118–126.…”

Section: Resultsmentioning

confidence: 99%

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Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

Machado¹,

Castrejón

Katchamart

et al. 2010

Annals of the Rheumatic Diseases

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ObjectiveTo develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA).Methods697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008–9 consisting of three separate rounds of discussions and modified Delphi votes. In the first round 10 clinical questions were selected. A bibliographic team systematically searched Medline, Embase, the Cochrane Library and ACR/EULAR 2007–2008 meeting abstracts. Relevant articles were reviewed for quality assessment, data extraction and synthesis. In the second round each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed.ResultsA total of 39 756 references were identified, of which 250 were systematically reviewed. Ten multinational key recommendations about the investigation and follow-up of UPIA were formulated. One recommendation addressed differential diagnosis and investigations prior to establishing the operational diagnosis of UPIA, seven recommendations related to the diagnostic and prognostic value of clinical and laboratory assessments in established UPIA (history and physical examination, acute phase reactants, autoantibodies, radiographs, MRI and ultrasound, genetic markers and synovial biopsy), one recommendation highlighted predictors of persistence (chronicity) and the final recommendation addressed monitoring of clinical disease activity in UPIA.ConclusionsTen recommendations on how to investigate and follow-up UPIA in the clinical setting were developed. They are evidence-based and supported by a large panel of rheumatologists, thus enhancing their validity and practical use.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

Machado¹,

Castrejón

Katchamart

et al. 2010

Annals of the Rheumatic Diseases

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“…These results showed higher sensitivity and lower specificity than those of Visser et al using the latex fixation test (sensitivity of 65.6%, specificity of 90.9%) (13). Vittecoq et al proposed that among ACR criteria, only RF detected by agglutination tests was taken into account, however, the measurement of IgM-RF by ELISA, in addition to latex fixation test, could increase the number of RF-positive cases in early RA (19). Visser et al showed that the diagnostic characteristics of the ELISAs for IgG and IgA RF in discriminating RA from non-RA were poor and the test characteristics of the ELISA for IgM RF and the latex fixation test proved to be much better, and compared reasonably well to each other, though the specificity of the latex fixation test was greater than that of the ELISA for IgM (13).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performances of Anti-Cyclic Citrullinated Peptides Antibody and Antifilaggrin Antibody in Korean Patients with Rheumatoid Arthritis

et al. 2005

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Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology. We studied the diagnostic performances of anti-cyclic citrullinated peptides antibody (anti-CCP) assay and recombinant anti-citrullinated filaggrin antibody (AFA) assay by enzyme linked immunosorbent assay (ELISA) in patients with RA in Korea. Diagnostic performances of the anti-CCP assay and AFA assay were compared with that of rheumatoid factor (RF) latex fixation test. RF, anti-CCP, and AFA assays were performed in 324 RA patients, 251 control patients, and 286 healthy subjects. The optimal cut off values of each assay were determined at the maximal point of area under the curve by receiver-operator characteristics (ROC) curve. Sensitivity (72.8%) and specificity (92.0%) of anti-CCP were better than those of AFA (70.3%, 70.5%), respectively. The diagnostic performance of RF showed a sensitivity of 80.6% and a specificity of 78.5%. Anti-CCP and AFA showed positivity in 23.8% and 17.3% of seronegative RA patients, respectively. In conclusion, we consider that anti-CCP could be very useful serological assay for the diagnosis of RA, because anti-CCP revealed higher diagnostic specificity than RF and AFA at the optimal cut off values and could be performed by easy, convenient ELISA method.

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“…Previous studies suggested that CV is one of the first antibodies to occur in the disease process and could be more sensitive than the synthetic CCP antibodies 14 17. However, the sensitivity of the anti-Sa (anti-citrullinated vimentin) antibody for detection of rheumatoid arthritis has been shown to be limited in established RA15 18 19 20 21 22 and early arthritis 8 23 24…”

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confidence: 99%

Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review

et al. 2009

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Rheumatoid factors, anti-filaggrin antibodies and low in vitro interleukin-2 and interferon-γ production are useful immunological markers for early diagnosis of community cases of rheumatoid arthritis. A preliminary study

Cited by 17 publications

References 29 publications

Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

Diagnostic Performances of Anti-Cyclic Citrullinated Peptides Antibody and Antifilaggrin Antibody in Korean Patients with Rheumatoid Arthritis

Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review

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