Rheumatoid Arthritis in the Young

Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

“…In addition to the fevers, some children rapidly defervesce and attain subnormal temperatures [ 8 , 64 , 65 ]. While the child is febrile, other symptoms such as arthritis, rash or serositis can worsen and cause significant disturbance of daily life; however, once the child has defervesced, it is not unusual to see a resumption of regular activities [ 8 , 62 , 66 ].…”

“…Arthritis is the second most common presenting symptom [ 5 ], and arthralgias can precede the arthritis [ 65 , 66 ]. According to Behrens et al, 88% of children presented with arthritis [ 5 ].…”

“…Sir George Fredrick Still himself did not describe a rash in the depiction of the disease. It was not until more than 50 years later that attention was given to this unique finding [ 66 , 75 ]. Evanescent in nature and bright salmon pink in color, this rash is morbilliform, macular, often with central clearing, and tends to be migratory and widespread [ 64 , 75 , 76 ].…”

Therapy of "Felty's Syndrome"

“…Hepatosplenomegaly is a not uncommon finding in rheumatoid disease, and Schlesinger (1949) found it present in 50 per cent. of his series of cases of Still's disease.…”

The History of Pediatric Rheumatology

“…Between 1940 and 1960, several publications addressed chronic arthritis in children (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). The condition was generally considered a single entity and confusion remained about its relationship to adult rheumatoid arthritis, the various disease manifestations, relationship to the newly described rheumatoid factors, and appropriate nomenclature.…”