Rheumatic diseases in North America's indigenous peoples

Peschken, Christine A.; Esdaile, John M.

doi:10.1016/s0049-0172(99)80003-1

Cited by 127 publications

(97 citation statements)

References 73 publications

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“…4 Moreover, as is the case with a number of the NAN populations that have been studied, we have shown that the Cree/Ojibway population in Central Canada has a high prevalence of SE alleles, specifically *0404 and *1402. 8 Because of the high prevalence of SE in the population, we looked for SNP associations in non-HLA regions that may further predispose NAN individuals to RA, or alternatively, protect them from the risk associated with SE.…”

Section: Discussionsupporting

confidence: 55%

“…1 However, several North American Native (NAN) populations have substantially higher prevalence rates, estimated as high as 5.3% in the Pima of Arizona and 2.4% in the Tlingit of Alaska. [2][3][4] The shared epitope (SE) hypothesis postulates that RA predisposing alleles of the HLA-DRB1 locus encode for a positively charged QK(R)RAA sequence in position 70-74 in the third hypervariable region of the molecule. 5 In most populations, the SE sequence is found in HLA-DRB1*04 alleles.…”

Section: Introductionmentioning

confidence: 99%

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Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

et al. 2011

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Most of the genetic risk for rheumatoid arthritis (RA) is conferred by 'shared epitope' (SE), encoding alleles of HLA-DRB1. Specific North American Native (NAN) populations have RA prevalence rates of 2-5%, representing some of the highest rates estimated worldwide. As many NAN populations also demonstrate a high background frequency of SE, we sought to determine whether other genetic factors contribute to disease risk in this predisposed population. RA patients (n ¼ 333) and controls (n ¼ 490) from the Cree/Ojibway NAN population in Central Canada were HLA-DRB1 typed and tested for 21 single-nucleotide polymorphisms (SNPs) that have previously been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL. Our findings indicate that SE is prevalent and represents a major genetic risk factor for RA in this population (82% cases versus 68% controls, odds ratio ¼ 2.2, 95% confidence interval 1.6-3.1, Po0.001). We also demonstrate that in the presence of SE, the minor allele of MMEL1-TNFRSF14 significantly reduces RA risk in a dominant manner, whereas TRAF1-C5 increases the risk. These findings point to the importance of non-HLA genes in determining RA risk in a population with a high frequency of disease predisposing HLA-DRB1 alleles.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

et al. 2011

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“…Geographic and ethnic factors also influence incidence and prevalence data. The prevalence of RA is approximately 0.5-1.1% in whites (13,16,17); 0.1% in rural Africans; and 5% in Pima, Blackfeet, and Chippewa Indians (13,17). Some studies showed declining incidences and prevalences after the 1960s (15).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population‐based study in Taiwan

See

Kuo

et al. 2013

Arthritis Care & Research

109

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“…Research conducted in selected reservation communities across the US found that certain autoimmune rheumatic diseases are more prevalent among American Indians than either non-Indians or Alaskan Natives and that this difference is most likely genetic in origin (2). American Indian populations have been reported to have a higher prevalence of inflammatory arthritides, including rheumatoid arthritis (3)(4)(5)(6), systemic lupus erythematosus (3,7,8), and scleroderma (9).…”

Section: Introductionmentioning

confidence: 99%

Arthritis beliefs and self‐care in an urban American Indian population

Kramer¹,

Harker²,

Wong³

2002

Arthritis & Rheumatism

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Objective. To describe beliefs and self-care strategies of American Indians with chronic arthritis joint pain. Method. In-depth interviews were conducted with a convenience sample of urban-dwelling American Indians (n ‫؍‬ 56) concerning self-care and beliefs about arthritis; objective measures of arthritis disease activity were obtained through standardized interview protocols. Results. Joint pain was not generally assumed to be arthritis nor directly related to aging. Belief that chronic pain affecting multiple joints was a serious and unexpected condition oriented American Indians' decisions to seek medical attention. However, verbal communications about pain may be subtle or under emphasized. Few coping strategies were used to control either chronic or episodic pain. Conclusions. Chronic arthritis pain may not be optimally managed in this population. Cultural assessment should recognize that American Indian patients may understate serious symptoms. Community educational interventions should target this population to enhance self-care, pain management, and communication of arthritis symptoms to physicians.

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Rheumatic diseases in North America's indigenous peoples

Cited by 127 publications

References 73 publications

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population‐based study in Taiwan

Arthritis beliefs and self‐care in an urban American Indian population

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