“…Clinical symptoms involve recurrent flares of acute arthritis, chronic arthropathy, tophi, uric acid urolithiasis, and renal impairment [1,2]. The affected joints the Taiwan general population from 2000 to 2008, the prevalence of rheumatoid arthritis was 52.4 per 100,000 persons, and the incidence was 17.3 per 100,000 person-years [8]. A multicenter study of UK general practices showed a 3-fold rise in gout occurrence between the 1970s and the 1990s (from 0.03 to 0.095%) [9] and a 1.4% rise from 2000 to 2005 compared to IMS databases from Germany and UK [10].…”