Rheumatic diseases are associated with a higher risk of dementia: A nation‐wide, population‐based, case‐control study

Chen, Kuan-Ting; Chen, Yen‐Chung; Fan, Yu-Hsi; Lin, Wen-Xiu; Lin, Wun-Cin; Wang, Yu‐Hsun; Lin, Lichi; Chiou, Jeng‐Yuan; Wei, James Cheng‐Chung

doi:10.1111/1756-185x.13246

Cited by 34 publications

(48 citation statements)

References 32 publications

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“…In the longitudinal analyses, we found that individuals with OA show a steeper decline in HpVR compared with those without OA. This finding was consistent with previous studies, suggesting that OA increases the risk of cognitive impairment (Huang et al, 2015;Chen et al, 2018;Weber et al, 2019). Further, a previous study found that nearly 40% of patients with AD have OA (Wang et al, 2018).…”

Section: Discussionsupporting

confidence: 93%

“…Osteoarthritis (OA) is a common and debilitating disease that influences one or more joints of the body (Hunter and Bierma-Zeinstra, 2019). Emerging evidence demonstrates that OA is also a risk factor for cognitive deficits (Huang et al, 2015;Chen et al, 2018;Weber et al, 2019), as nearly 40% of patients with Alzheimer's disease (AD) have OA (Wang et al, 2018). Further, a previous preclinical study found that OA can accelerate and exacerbate AD pathologies (Kyrkanides et al, 2011), supporting the notion that OA may have a detrimental impact on AD pathogeneses.…”

Section: Introductionmentioning

confidence: 97%

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Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

Tong

Gao

et al. 2020

Front. Aging Neurosci.

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Objective: To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10 3) over time among cognitively normal older people. Methods: We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included. Results: In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared with individuals without OA, those with OA showed a faster decline in HpVR over time when controlling for other potential confounders, including age, educational attainment, gender, and APOE4 genotype. Conclusion: OA status was significantly associated with a change in HpVR over time among individuals with NC.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

Tong

Gao

et al. 2020

Front. Aging Neurosci.

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“…Thereafter, 25 studies were thought to be eligible and evaluated for full-text review. Sixteen studies were excluded, and the nine remaining studies (Abuabara et al, 2010;Feldman et al, 2015;Chen et al, 2018;Mitchell et al, 2018;Pezzolo et al, 2018;Huang et al, 2019;Leisner et al, 2019;Lin et al, 2019;Kim et al, 2020) were included. The search strategy and study selection are shown in Figure 1.…”

Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

“…Of the nine studies, four were conducted in East Asia (Chen et al, 2018;Huang et al, 2019;Lin et al, 2019;Kim et al, 2020), three in Europe (Abuabara et al, 2010;Pezzolo et al, 2018;Leisner et al, 2019), and two in the USA (Feldman et al, 2015;Mitchell et al, 2018). Five were cohort studies (Abuabara et al, 2010;Pezzolo et al, 2018;Huang et al, 2019;Leisner et al, 2019;Kim et al, 2020); two were case-control studies (Chen et al, 2018;Lin et al, 2019); one was a cross-sectional study (Mitchell et al, 2018), and the remaining one was a retrospective study (Feldman et al, 2015). Almost all the studies used the codes of the International Statistical Classification of Diseases and Related Health Problems as a diagnostic basis.…”

Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

Association Between Psoriasis and Dementia: Current Evidence

Liu

Chen

Li³

et al. 2020

Front. Aging Neurosci.

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Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1. Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06-1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29-3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11-1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09-1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72-4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity. Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths.

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“…6,7 One hypothesis for dementia in AS is the neurodegeneration caused by systemic inflammation. 8 Long-term or high-dose treatments with antiinflammatory drugs are commonly used in rheumatic diseases and may decrease the volume of the hippocampus, causing cognitive impairment as well. 9 Neuropsychiatric involvement has been suggested to be important in AS patients as well.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Patients with Ankylosing Spondylitis

Vitturi

Suriano

Sousa

et al. 2020

Can. J. Neurol. Sci.

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ABSTRACT:Background:Little is known about the potential systemic effects of ankylosing spondylitis (AS) on the nervous system. We designed a study aiming to assess the frequency and clinical predictors of cognitive impairment in AS patients.Methods:We carried out a cross-sectional case–control study composed of consecutive patients with AS. Trained and blinded interviewers registered clinical-epidemiological data and applied a standardized neurological assessment for each subject of the study. At baseline, functional limitations were characterized using the Health Assessment Questionnaire. Cognitive impairment was evaluated with the Brief Cognitive Screening Battery, the Montreal Cognitive Assessment, and the Clinical Dementia Rating, while neuropsychiatric symptoms were investigated with the Hospital Anxiety and Depression Scale. Healthy controls were matched for age, educational attainment, sex, and comorbidities. We compared the neurological outcomes between case and controls, and we determined the clinical predictors of cognitive decline.Results:We included 40 patients (mean: 49.3 years) with AS and 40 healthy controls (mean: 48.8 years) in our study. In Brief Cognitive Screening Battery, patients with AS presented a statistically significant poor performance in the clock drawing test and in the verbal fluency. The mean Montreal Cognitive Assessment (MoCA) scores were significantly lower in AS subjects compared to the control group. Also, the prevalence of subjects classified as cognitively impaired according to MoCA was significantly higher in the AS group (90.0% vs. 57.5%, p = 0.02). Moreover, neuropsychiatric symptoms were more prevalent in AS patients. Worse functional limitations were associated with poor cognitive performance as well.Conclusions:Patients with AS might be more vulnerable to cognitive decline.

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Rheumatic diseases are associated with a higher risk of dementia: A nation‐wide, population‐based, case‐control study

Cited by 34 publications

References 32 publications

Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

Association Between Psoriasis and Dementia: Current Evidence

Cognitive Impairment in Patients with Ankylosing Spondylitis

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