Association Between Psoriasis and Dementia: Current Evidence

Abstract

Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1. Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06-1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29-3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11-1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09-1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72-4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity. Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths.

Prevalence and risk factors for cognitive impairment in patients with psoriasis

“…To evaluate guilty, an item from of a validated tool on family burden has been used. 4 Answers to the statement 'I feel guilty for my child's AD' were categorised into two groups: 'certainly yes'/'probably' (1); 'certainly not'/'I don't know' (0). Clinical severity evaluated by a proxy version of the Patient-Oriented Eczema Measure (POEM) was mild in 23.5%, moderate in 59.4% and severe in 17.1% of 251 patients.…”

“…However, there is limited information available on cognitive functioning in patients with psoriasis. [2][3][4] In this study, we prospectively enrolled patients with psoriasis for cognitive assessment and assessed potential risk factors associated with CI in these patients.…”

Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses

“…Compared with individuals without psoriasis, those with psoriasis were more likely to develop a dementia ( 32 ), nonvascular dementia ( 32 ), vascular dementia, ( 32 ) and Parkinson's disease ( 33 ) in our study ( Figure 5 ).…”

Association between Inflammatory Conditions and Alzheimer’s Disease Age of Onset in Down Syndrome

“…In contrast, several epidemiological studies have found a relationship between diabetes and the risk of AD [ 45 ] in the general population. Individuals with psoriasis have been reported to have an increased risk of developing dementia [ 46 ].…”