Rheumatic associations of autoimmune thyroid disease: a systematic review

Tagoe, Clément E.; Sheth, Tejas; Golub, Eugeniya; Sorensen, Karen

doi:10.1007/s10067-019-04498-1

Cited by 13 publications

(22 citation statements)

References 57 publications

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“…Autoimmune thyroid disease (AITD) is not an uncommon finding in patients with other autoimmune disorders (43, 44) such as rheumatoid arthritis (44). In addition, a systematic review suggested that AITD may be associated with osteoarthritis and chronic widespread pain, implicating AITD as an important risk factor for these conditions (45), independent of thyroid function. Despite these possible mechanisms that could change physical activity patterns, our results showed that thyroid autoimmunity itself is not associated with physical activity levels either.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function and Physical Activity: A Population-Based Cohort Study

Dueñas

Koolhaas

Voortman

et al. 2021

Thyroid

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Section: Discussionmentioning

confidence: 99%

Thyroid Function and Physical Activity: A Population-Based Cohort Study

Dueñas

Koolhaas

Voortman

et al. 2021

Thyroid

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“…Of possible relevance to the question of unresolved symptoms in HT discussed in the last section, a systematic review of the association between rheumatological conditions and HT confirmed the well-recognised excess of inflammatory arthritis, but also found evidence for an association with osteoarthritis, fibromyalgia and chronic widespread pain [47]. Evidence quality was too low to perform a meta-analysis.…”

Section: Associations With Htmentioning

confidence: 91%

An update on the pathogenesis of Hashimoto’s thyroiditis

Weetman

2020

J Endocrinol Invest

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It is 70 years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto’s thyroiditis. This short review to honour his passing focuses on the developments in our understanding of the causes and pathogenesis of HT over the last five years. Recent genetic studies have reported heritability estimates for HT and associated diseases for the first time, and emphasised the complexity of the genetic factors involved, including monogenic forms of HT. Environmental factors continue to be elucidated, especially as a side effect of drugs which modulate the immune system therapeutically. Regarding pathogenetic mechanisms, multiple cytokine networks have been identified which involve the thyroid cells in a circuit of escalating proinflammatory effects, such as the expression of inflammasome components, and an array of different defects in T regulatory cells may underlie the loss of self-tolerance to thyroid autoantigens. Finally, a number of studies have revealed fresh insights into disease associations with HT which may have both pathological and clinical significance, the most intriguing of which is a possible direct role of the autoimmune process itself in causing some of the persistent symptoms reported by a minority of patients with levothyroxine-treated HT.

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“…Although the etiology and pathogenesis of OA have not yet been fully clarified, aging, obesity, infection, trauma, and metabolic disorders are considered risk factors for OA [7,8]. Recent studies have demonstrated the important role of thyroid hormone metabolism in articular cartilage maintenance and the pathogenesis of OA [9][10][11]. Thyroid hormone is essential for endochondral ossification and the expression of genes that control chondrocyte maturation and matrix synthesis [12].…”

Section: Open Accessmentioning

confidence: 99%

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

et al. 2022

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Objectives Thyroid hormones play an instrumental role in chondrogenic differentiation and matrix maturation. However, studies investigating the relationship between thyroid function and the risk of osteoarthritis (OA) remain scarce. This study was designed to investigate the correlation between thyroid status and OA from a novel perspective of sensitivity to thyroid hormones. Methods The study included 8478 people from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. The sensitivity to thyroid hormone indices included Thyrotroph Thyroxine Resistance Index (TT4RI), Thyroid-stimulating hormone (TSHI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine /Free thyroxine (FT3/FT4), which were calculated based on serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Considering the complex survey design and sample weights, we employed multivariate linear regression models and stratified analysis to evaluate the correlation between sensitivity to thyroid hormone indices and OA. Results Study results indicated that participants with OA had elevated TT4RI, TSHI, and TFQI levels, and lower FT3/FT4 levels compared to those with non-arthritis. After adjusting for other covariates, FT3/FT4 was negatively associated with the risk of OA (OR = 1.162, 95%CI 1.048–1.478, P = 0.021); (OR = 1.261, 95%CI 1.078–1.623, P = 0.042). In subgroup analyses stratified by gender and BMI, participants with OA had higher TFQI levels compared to those without OA in both genders. (OR = 1.491, 95%CI 1.070–2.077, P = 0.018); (OR = 2.548, 95%CI 1.929–3.365, P < 0.001). The higher TFQI levels were consistently associated with the increased prevalence of OA in the BMI (< 18.5 kg/m2) group after adjusting for different covariates, but not in other BMI groups. In, addition, TFQI performed better than FT3/FT4, TSHI, and TT4RI on ROC analyses for OA prediction. Conclusions The levels of FT3/FT4, TSHI, TT4RI, and TFQI are strongly associated with the prevalence of OA, which illustrates the complex correlation between the thyroid system and chondrogenic differentiation. TFQI may be used as a helpful indicator to predict OA and provide novel ideas for the evaluation and treatment of OA.

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Rheumatic associations of autoimmune thyroid disease: a systematic review

Cited by 13 publications

References 57 publications

Thyroid Function and Physical Activity: A Population-Based Cohort Study

Thyroid Function and Physical Activity: A Population-Based Cohort Study

An update on the pathogenesis of Hashimoto’s thyroiditis

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

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