Rheopheresis in vascular diseases

Vass, Melinda; Diószegi, Ágnes; Németh, Norbert; Sógor, Viktória; Baráth, Sándor; Szalai, Eszter; László, M; Soltész, Pál

doi:10.3233/ch-168004

Cited by 6 publications

(4 citation statements)

References 13 publications

(1 reference statement)

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“…In a prospective cohort study examining BMI and progression of AMD, increasing vigorous physical activity to at least three times per week was associated with a 25% reduction in rate of AMD progression ( p = .05), and a reduction in waist circumference was associated with a lower relative risk of AMD progression ( p = .02) 30 . There is also evidence that improving one's lipid profile and plasma viscosity by reducing levels of LDL and other high‐molecular weight molecules can improve visual acuity and slow disease progression in patients with AMD 31 . Exudative AMD necessitates more invasive treatment, with intravitreal anti‐VEGF injections being the gold‐standard therapy.…”

Section: Resultsmentioning

confidence: 99%

“…30 There is also evidence that improving one's lipid profile and plasma viscosity by reducing levels of LDL and other high-molecular weight molecules can improve visual acuity and slow disease progression in patients with AMD. 31 Exudative AMD necessitates more invasive treatment, with intravitreal anti-VEGF injections being the gold-standard therapy. Laser photocoagulation can be used to treat fovea-sparing CNV but may fail to adequately cover the entire lesion.…”

Section: Obesity and Age-related Macular Degenerationmentioning

confidence: 99%

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Shedding light on eye disease in obesity: A review

et al. 2023

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SummaryObesity is known to be associated with numerous ocular manifestations, including but not limited to, diabetic retinopathy (DR), age‐related macular degeneration (AMD), cataracts, glaucoma, and dry eye disease. This review aims to provide an overview of the ophthalmological findings in obesity. A literature search was conducted using PubMed and Cochrane databases for studies describing randomized clinical trials, meta‐analyses, systematic reviews, and observational studies published from 1 January 2017 to 1 April 2023. The search terms used included relevant keywords such as ‘obesity’, ‘body mass index’, ‘waist‐to‐hip ratio’, ‘bariatric’, ‘ophthalmology’, ‘eye disease’, ‘myopia’, ‘retinopathy’, ‘glaucoma’, and ‘cataract’. This literature search was performed on 1 April 2023. Obesity is associated with increased risk of developing DR, a sight‐threatening complication of diabetes mellitus. Similarly, obesity has been shown to increase risk of AMD, cataracts, glaucoma, and ocular surface disease. Multiple mechanisms linking obesity to ophthalmic disease have been proposed. Adipose tissue produces various inflammatory cytokines that can affect ocular tissues, leading to disease progression. Additionally, obesity is associated with systemic metabolic changes that can influence ocular health. Bariatric surgery has been shown to be protective against development of ophthalmic disease. Obesity is a significant risk factor for several ophthalmological diseases. Healthcare providers should encourage weight loss in patients with overweight or obesity to prevent or delay the onset of ocular complications. Further research is needed to better understand the underlying mechanisms of this association, and to identify effective strategies for preventing or managing ophthalmic disease in patients with obesity.

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Section: Resultsmentioning

confidence: 99%

Section: Obesity and Age-related Macular Degenerationmentioning

confidence: 99%

Shedding light on eye disease in obesity: A review

et al. 2023

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“…But only few data are available and large clinical trials are needed to explore the full capacity of the method. 2,8,9…”

Section: Introductionmentioning

confidence: 99%

Rheopheresis: A narrative review

Kosmadakis

2022

Int J Artif Organs

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Introduction: Rheopheresis is an extracorporal selective double-filtration procedure with an initial separation of plasma from the whole blood and a further filtration of the plasma through a second filter in order to eliminate a certain number of high molecular weight proteins such LDL, Lp(a), fibrinogen, α2-macroglobulin, Factor von Willebrand, and IgM Immunoglobulin. Methods: In this narrative review we discuss the available data on the effects of Rheopheresis in various clinical conditions. Results: Rheopheresis is considerd to exert a rapid effect on clinical conditions associated with seriously affected microcirculation and rheologic parameters such as, the dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHS), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis and diabetic foot. Conclusions: Rheopheresis is a promising technique for conditions associated with affected microcirculatory rheologic parameters

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“…In addition, rheopheresis reduces platelet aggregation and improves erythrocyte deformability and endothelial status. 1 , 4 , 5 As recommended by the American Society for Apheresis, indications for treatment include age-related macular degeneration and sensorineural hearing loss. 6 According to the international recommendation, the first treatments were performed successfully in dry macular degeneration.…”

Section: Introductionmentioning

confidence: 99%

Monitoring and recovery of hyperglycaemia-induced endothelial dysfunction with rheopheresis in diabetic lower extremity ulceration with hyperviscosity

Gál

Asbóth

Vass

et al. 2022

Diabetes and Vascular Disease Research

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Aims Rheopheresis is an extracorporeal haematotherapy that improves haemorheological status by filtering proteins that enhance blood viscosity. It also has anti-inflammatory effects by removing inflammatory cytokines. Our study aims to examine the effects of rheopheresis on the endothelial status in diabetic lower extremity ulceration. Methods In vitro experiments were performed in a HUVEC model to mimic hyperglycaemic stress. We determined the changes in gene expression levels of IL-6, IL-8, TNF-alpha, endothelin convertase enzyme, ET-1, and NO synthase, as well as the ROS and intracellular GSH levels upon hyperglycaemia. In in vivo studies, two rheopheresis procedures were performed on seven patients with diabetic lower extremity ulceration with hyperviscosity, and we measured the changes in plasma concentrations of ET-1, TXB2, SOD enzyme activity, and extracellular components of the glutathione pool depending on treatments. Results Our results showed that hyperglycaemia increases endothelial expression of inflammatory cytokines, ET-1, and endothelin convertase enzyme, while NO synthase was decreased. As a result of rheopheresis, we observed decreased ET-1 and TXB2 concentrations in the plasma and beneficial changes in the parameters of the glutathione pool. Conclusion To summarize our results, hyperglycaemia-induced oxidative stress and endothelial inflammation can be moderated by rheopheresis in diabetic lower extremity ulceration with hyperviscosity.

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Rheopheresis in vascular diseases

Abstract: Abstract.Rheopheresis is an extracorporal selective double-filtration procedure. In the first part of the treatment the blood 8 is passes through the plasma filter, which separates blood cells from the plasma. Then the plasma flow to a second filter

Cited by 6 publications

References 13 publications

Shedding light on eye disease in obesity: A review

Shedding light on eye disease in obesity: A review

Rheopheresis: A narrative review

Monitoring and recovery of hyperglycaemia-induced endothelial dysfunction with rheopheresis in diabetic lower extremity ulceration with hyperviscosity

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