RTX offered no additional benefit over placebo to our patients with active and moderate to severe GO and carried with it non-negligible adverse effects.

Observational evidence warranting low confidence suggests that compared to transdermal ET, oral ET may be associated with increased risk of VTE and DVT, but not MI.

Key Points Question What is the association between low levels of low-density lipoprotein cholesterol and risk of sepsis in patients admitted to the hospital with serious infection? Findings In this cohort study of deidentified electronic medical records of patients admitted to the hospital with infection, measured levels of low-density lipoprotein cholesterol in 3961 patients and a low-density lipoprotein cholesterol genetic risk score in 7804 patients were not associated with increased risk of sepsis after adjusting for comorbidities. Meaning Levels of low-density lipoprotein cholesterol are not directly associated with the risk of sepsis or poor outcomes in patients hospitalized with infection.

No abstract