Rheologische Ver�nderungen des Blutes in der normalen und pathologischen Schwangerschaft und deren Einflu� auf die Sauerstoffdiffusion

Heilmann, L.; Mattheck, C.; Kurz, Eduard

doi:10.1007/bf00667368

Cited by 19 publications

(6 citation statements)

References 37 publications

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“…The results are consistent with other observations on the significance of WBV for fetal outcome. Based on a cross-sectional study, Heilmann et al pointed out the importance of WBV for fetal oxygenation (9). In our analysis of the longitudinal changes in Vlow, those preg- Buchan also illustrated these amenorrhea-dependent changes in WBV from cross-sectional data (11).…”

Section: Discussionsupporting

confidence: 62%

Longitudinal Changes in Blood Viscosity Are Correlated With Fetal Outcome

Zondervan

Oosting

Smorenberg-Schoorl

et al. 1988

Acta Obstet Gynecol Scand

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The importance of longitudinal changes in maternal Whole Blood Viscosity (WBV) for fetal well-being was investigated. Consecutive WBV data were available, obtained from 44 pregnancies before 36 0/7 weeks. An increase in WBV was found to be associated with an unfavorable fetal outcome. This result might be considered as clinical evidence supporting the hypothesis that maternal WBV contains information on the efficacy of placental perfusion.

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Section: Discussionsupporting

confidence: 62%

Longitudinal Changes in Blood Viscosity Are Correlated With Fetal Outcome

Zondervan

Oosting

Smorenberg-Schoorl

et al. 1988

Acta Obstet Gynecol Scand

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“…A correlation between AT III and maternal complications in preeclampsia has been reported [11], A significant influence of WBV was estab lished for fetal prognosis with regard to intrauterine oxygenation, independent of blood pressure. This result supports the hy pothesis that WBV is associated with oxygen diffusion [12], From retrospective studies in large numbers of patients, 'hemoconcentration' has been reported to be related to poor fetal outcome [13].…”

Section: Discussionsupporting

confidence: 75%

Maternal Whole Blood Viscosity in Pregnancy Hypertension

Zondervan

Oosting

Smorenberg-Schoorl

et al. 1988

Gynecol Obstet Invest

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Hemoconcentration is prominent in preeclampsia. Concomitant changes in the flow properties of maternal blood, i.e. in whole blood viscosity (WBV), might be related to the occurrence of fetal or maternal complications. To test this hypothesis, WBV was estimated in 228 pregnancies. Patients were assigned to one of four groups according to maximum diastolic blood pressure. Significantly higher WBV values were found in the more hypertensive groups throughout pregnancy. WBV data, obtained between 26 and 36 weeks of amenorrhea, contributed significantly, independently of hypertension, to the prediction of fetal outcome. With regard to maternal complications, no significant contribution of WBV data could be established independently of blood pressure. The results support the hypothesis that WBV is a determining factor in the efficacy of placental perfusion.

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“…The first two are the erythrocyte sedimentation rate (ESR) (1098, 1099) and the red cell distribution width (RDW) (1100) [but cf. Ref.…”

Section: Clotting Coagulopathies and Fibrinogen In Pementioning

confidence: 99%

A Dormant Microbial Component in the Development of Preeclampsia

Kell

Kenny

2016

Front. Med.

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Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation. In particular, bacterial products such as lipopolysaccharide (LPS), also known as endotoxin, are well known as highly inflammagenic and stimulate an innate (and possibly trained) immune response that exacerbates the inflammation further. The known need of microbes for free iron can explain the iron dysregulation that accompanies PE. We describe the main routes of infection (gut, oral, and urinary tract infection) and the regularly observed presence of microbes in placental and other tissues in PE. Every known proteomic biomarker of “preeclampsia” that we assessed has, in fact, also been shown to be raised in response to infection. An infectious component to PE fulfills the Bradford Hill criteria for ascribing a disease to an environmental cause and suggests a number of treatments, some of which have, in fact, been shown to be successful. PE was classically referred to as endotoxemia or toxemia of pregnancy, and it is ironic that it seems that LPS and other microbial endotoxins really are involved. Overall, the recognition of an infectious component in the etiology of PE mirrors that for ulcers and other diseases that were previously considered to lack one.

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Rheologische Ver�nderungen des Blutes in der normalen und pathologischen Schwangerschaft und deren Einflu� auf die Sauerstoffdiffusion

Cited by 19 publications

References 37 publications

Longitudinal Changes in Blood Viscosity Are Correlated With Fetal Outcome

Longitudinal Changes in Blood Viscosity Are Correlated With Fetal Outcome

Maternal Whole Blood Viscosity in Pregnancy Hypertension

A Dormant Microbial Component in the Development of Preeclampsia

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