Abstract:Water-soluble polyacrylamides have often been used to modify flow response in various water-based technologies and industrial processes, including paints, water treatment, paper manufacturing, and chemical enhanced oil recovery. Polymers are...
“…Moreover, the peak intensity of the alkyl C-H groups was considerably increased, and new peaks appeared for O-H at 1364 cm −1 , C-N for 1542 cm −1 , and 1637 cm −1 for C=O groups, respectively, which implies that the copolymer has been modified onto the MS@PNIPAm-PAAm NPs. From the FTIR analysis data, the surface modification of the PNIPAm-PAAm copolymer onto the MS@GPTMS NPs was confirmed [ 35 ].…”
A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6.5, and 5.0) and temperatures (such as 25 °C and 42 °C, respectively). The surface conjugated copolymer (PNIPAm-PAAm) acts as a gatekeeper below the lower critical solution temperature (LCST) (<32 °C) and as a collapsed globule structure above LCST (>32 °C), resulting in controlled drug delivery from the MS@PNIPAm-PAAm system. Furthermore, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cellular internalization results support the prepared MS@PNIPAm-PAAm NPs being biocompatible and readily taken up by MDA-MB-231 cells. The prepared MS@PNIPAm-PAAm NPs, with their pH-responsive drug release behavior and good biocompatibility, could be used as a drug delivery vehicle where sustained drug release at higher temperatures is required.
“…Moreover, the peak intensity of the alkyl C-H groups was considerably increased, and new peaks appeared for O-H at 1364 cm −1 , C-N for 1542 cm −1 , and 1637 cm −1 for C=O groups, respectively, which implies that the copolymer has been modified onto the MS@PNIPAm-PAAm NPs. From the FTIR analysis data, the surface modification of the PNIPAm-PAAm copolymer onto the MS@GPTMS NPs was confirmed [ 35 ].…”
A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6.5, and 5.0) and temperatures (such as 25 °C and 42 °C, respectively). The surface conjugated copolymer (PNIPAm-PAAm) acts as a gatekeeper below the lower critical solution temperature (LCST) (<32 °C) and as a collapsed globule structure above LCST (>32 °C), resulting in controlled drug delivery from the MS@PNIPAm-PAAm system. Furthermore, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cellular internalization results support the prepared MS@PNIPAm-PAAm NPs being biocompatible and readily taken up by MDA-MB-231 cells. The prepared MS@PNIPAm-PAAm NPs, with their pH-responsive drug release behavior and good biocompatibility, could be used as a drug delivery vehicle where sustained drug release at higher temperatures is required.
“…[108,109] GPTMS and silica NPs covalently bind during the sol-gel process, and the epoxy ring of the former was converted into a diol by the nucleophilic attack of alginate. [62,110,111] Shin et al explained that PDRN plays a role in creating semi-interpenetrating hydrogel networks, which enhance the mechanical properties of hydrogels, although its strength cannot compete with that of other strengthening fillers, such as graphene oxide and nanoclay. [99] The well-distributed DNA observed in the current study exerted nanoscale reinforcement effects that were similar to those described by Shin et al [36] and enhanced the dispersion of stress from the polymer chains to the DNA.…”
Section: Physicochemical Characterization Of 3d-printed Hydrogel Dres...mentioning
Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials are needed to effectively treat such wounds that vary in shape and depth. The continuous development of 3D‐printing technology along with artificial intelligence has increased the precision, versatility, and compatibility of various materials, thus providing the considerable potential to meet the abovementioned needs. Herein, functional 3D‐printing inks comprising DNA from salmon sperm and DNA‐induced biosilica inspired by marine sponges, are developed for the machine learning‐based 3D‐printing of wound dressings. The DNA and biomineralized silica are incorporated into hydrogel inks in a fast, facile manner. The 3D‐printed wound dressing thus generates provided appropriate porosity, characterized by effective exudate and blood absorption at wound sites, and mechanical tunability indicated by good shape fidelity and printability during optimized 3D printing. Moreover, the DNA and biomineralized silica act as nanotherapeutics, enhancing the biological activity of the dressings in terms of reactive oxygen species scavenging, angiogenesis, and anti‐inflammation activity, thereby accelerating acute and diabetic wound healing. These bioinspired 3D‐printed hydrogels produce using a DNA‐induced biomineralization strategy are an excellent functional platform for clinical applications in acute and chronic wound repair.
“…Besides, the incorporation of metal–organic frameworks (MOFs) into the CA matrix has been found to endow the resulting nanocomposites with superior mechanical performance . Among these innumerable nanomaterials, silica (SiO 2 ) nanoparticles have aroused considerable interest due to their abundant hydroxyl groups, large specific surface area, antibacterial activity, low cost, nontoxicity, excellent heat resistance, and their specific affinity toward the surface of CA. ,− As previously reported, when SiO 2 nanoparticles are added into the CA matrix, the selectivity, durability, thermal stability, thermal storage/retrieval property, thermal insulation capability, salt rejection capacity, and fouling resistance of the CA film can be improved effectively. − Therefore, the addition of SiO 2 would be helpful to improve the comprehensive properties and extend the lifespan of the CA film.…”
It is significant to understand the interfacial interactions involved between the cellulose acetate (CA) and dispersed nanomaterials, in which the enhanced interaction improves the mechanical behavior of CA. In this work, the amendments of CA with SiO 2 nanoparticles have been found to be endowed by grafting varying concentrations (0, 3, 5, and 6%) of octadecyltrichlorosilane (OTS). Aided by SiO 2 colloid probe atomic force microscopy (AFM with a probe diameter of 20 μm), the adhesion force between CA and SiO 2 is found to be programmable by tuning OTS concentrations functionalized onto SiO 2 surfaces. The adhesion forces of 5% OTSfunctionalized SiO 2 with CA are the strongest, followed by the ones of 0, 3, and 6% OTS, resulting in a smoother and denser morphology on the film with 5% OTS. The AFM-measured approaching force−distance curves have been further compared to predictions by the extended Derjaguin−Landau−Verwey−Overbeek (XDLVO) theory, in which the XDLVO force is summed as the Liftshitz−van der Waals force (F LW ), the electrostatic double-layer force (F EL ), and the acid−base interaction force (F AB ). F LW and F EL do not change significantly with OTS concentrations functionalized onto SiO 2 . However, F AB is sensitive to the functionalized OTS concentration onto SiO 2 and significantly contributes to the interaction force of the composite films with 5% OTS, promoting the formation of a smooth and dense surface feature with a considerable mechanical performance demonstrated by load−displacement curves from a nanoindenter. This is highly encouraging and suggests that nanomaterials can be incorporated into CA to effectively improve their mechanical compatibility by programming the interaction between the CA matrix and nanomaterials.
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