Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery

Thirupathi, Kokila; Moorthy, Madhappan Santha; Radhakrishnan, Shankar; Ulagesan, Selvakumari; Nam, Taek‐Jeong; Phan, Thi Tuong Vy; Kim, Seong-Cheol

doi:10.3390/pharmaceutics15030795

Cited by 17 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As lipid-based, polymeric, and inorganic nanoparticles are made more precisely, they can be improved for drug administration [8]. To optimize the delivery of Cur, a variety of nanocarriers have been designed [9,10]. Cur encapsulation in biopolymeric particles, for example, or conjugation with nanoparticles, can be employed to increase Cur stability, absorption, and distribution to target areas.…”

Section: Introductionmentioning

confidence: 99%

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Moorthy

Kim

2023

Gels

Self Cite

View full text Add to dashboard Cite

Curcumin (Cur) is a beneficial ingredient with numerous bioactivities. However, due to its low solubility and poor bioavailability, its therapeutic application is limited. In this work, we prepared poly-N-isopropylacrylamide p(NIPAm) and polyallylamine p(Am)-based nanogel (p(NIPAm-co-Am)) NG for a dual pH- and temperature-sensitive copolymer system for drug delivery application. In this copolymer system, the p(NIPAm) segment was incorporated to introduce thermoresponsive behavior and the p(Am) segment was incorporated to introduce drug binding sites (amine groups) in the resulting (p(NIPAm-co-Am)) NG system. Various instrumental characterizations including 1H nuclear magnetic resonance (1H NMR) spectroscopy, Fourier transform infrared (FT-IR) analysis, scanning electron microscopy (SEM), zeta potential, and particle size analysis were performed to confirm the copolymer synthesis. Curcumin (Cur), an anticancer bioactive substance, was employed to assess the in vitro drug loading and release performance of the resulting copolymer nanogels system at varied pH levels (pH 7.2, 6.5, and 4.0) and temperatures (25 °C, 37 °C, and 42 °C). The cytocompatibility of the p(NIPAm-co-Am) NG sample was also tested on MDA-MB-231 cells at various sample concentrations. All the study results indicate that the p(NIPAm-co-Am) NG produced might be effective for drug loading and release under pH and temperature dual-stimuli conditions. As a result, the p(NIPAm-co-Am) NG system has the potential to be beneficial in the use of drug delivery applications in cancer therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Moorthy

Kim

2023

Gels

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is anticipated that the developed pNIPAm-co-pGMA-Mela hydrogel system could considerably improve drug delivery to specific sites under pH and/or temperature stimuli due to the presence of temperature-responsive pNIPAm segments and pH-responsive pGMA-Mela segments. The hydrophobic pNIPAm units in the pNIPAm-co-pGMA-Mela hydrogel can accommodate hydrophobic drugs, while the pGMA can accommodate hydrophilic drugs due to the presence of hydrophilic melamine groups in the hydrogel system [ 33 ]. The loaded drugs can then be delivered selectively by altering the pH or temperature stimuli.…”

Section: Resultsmentioning

confidence: 99%

pNIPAm-Based pH and Thermoresponsive Copolymer Hydrogel for Hydrophobic and Hydrophilic Drug Delivery

Mohan,

Santhamoorthy,

Phan

et al. 2024

Gels

Self Cite

View full text Add to dashboard Cite

The regulated and targeted administration of hydrophobic and hydrophilic drugs is both promising and challenging in the field of drug delivery. Developing a hydrogel which is responsive to dual stimuli is considered a promising and exciting research area of study. In this work, melamine functionalized poly-N-isopropyl acrylamide-co-glycidyl methacrylate copolymer has been developed by copolymerizing glycidyl methacrylate (GMA) monomer with N-isopropyl acrylamide (NIPAm) and further functionalized with melamine units (pNIPAm-co-pGMA-Mela). The prepared pNIPAm-co-pGMA-Mela copolymer hydrogel was characterized using various characterization techniques, including 1H NMR, FTIR, SEM, zeta potential, and particle size analysis. A hydrophobic drug (ibuprofen, Ibu) and hydrophilic drug (5-fluorouracil, 5-Fu) were selected as model drugs. Dual pH and temperature stimuli-responsive drug release behavior of the pNIPAm-co-pGMA-Mela hydrogel was evaluated under different pH (pH 7.4 and 4.0) and temperature (25 °C, 37 °C, and 45 °C) conditions. Furthermore, the in vitro biocompatibility of the developed pNIPAm-co-pGMA-Mela copolymer hydrogel was determined on MDA-MB-231 cells. The pH and temperature-responsive drug delivery study results reveal that the pNIPAm-co-pGMA-Mela hydrogel system is responsive to both pH and temperature stimuli and exhibits about ~100% of Ibu and 5-Fu, respectively, released at pH 4.0/45 °C. Moreover, the MTT assay and hemocompatibility analysis results proved that the pNIPAm-co-pGMA-Mela hydrogel system is biocompatible and hemocompatible, suggesting that that it could be used for drug delivery applications. The experimental results suggest that the proposed pNIPAm-co-pGMA-Mela hydrogel system is responsive to dual pH and temperature stimuli, and could be a promising drug carrier system for both hydrophilic and hydrophobic drug delivery applications.

show abstract

“…For example, most cancerous tissues have lower pH values (extracellular tumour pH ≈ 6.4–6.8, endosome pH ≈ 5.5, and lysosome pH ≈ 5.0) than healthy tissue and the bloodstream (pH ≈ 7.4) [ 127 ]. Applying a biocompatible polymer to the MSN surface to seal pores is a promising approach to creating desirable pH- and temperature-sensitive drug delivery systems [ 128 , 129 , 130 , 131 , 132 ]. The use of thermosensitive polymers allows for controlled drug release due to the fundamental differences in temperature between normal and cancerous tissue cells, allowing for tumour selectivity.…”

Section: Stimuli That Control Drug Releasementioning

confidence: 99%

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Kovtareva,

Kusepova,

Tazhkenova

et al. 2024

Polymers

View full text Add to dashboard Cite

The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

show abstract

Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery

Cited by 17 publications

References 46 publications

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

pNIPAm-Based pH and Thermoresponsive Copolymer Hydrogel for Hydrophobic and Hydrophilic Drug Delivery

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Contact Info

Product

Resources

About