Rheological properties of saliva substitutes containing mucin, carboxymethylcellulose or polyethylenoxide

Vissink, Arjan; Waterman, H. A.; Sgravenmade, Ej; Panders, Ak; Vermey, A

doi:10.1111/j.1600-0714.1984.tb01397.x

Cited by 101 publications

(63 citation statements)

References 9 publications

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“…With ceramic, it was the opposite, and there were no significant differences with stainless steel crowns. It has been stated that mucin-based substitutes (e.g., Mouth Kote®) possess lubricating qualities comparable to human saliva (16). Our results indicate that that may be true with ceramic and stainless steel, but not with denture teeth.…”

Section: Discussionsupporting

confidence: 46%

The effects of salivas on occlusal forces

McCrea

Katona

Eckert

2014

J of Oral Rehabilitation

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The effects of salivas on occlusal forces SUMMARY Contacting surfaces of opposing teeth produce friction that, when altered, changes the contact force direction and/or magnitude. Since friction can be influenced by several factors, including lubrication and the contacting materials, the aim of this study is to measure the occlusal load alterations experienced by teeth with the introduction of different salivas and dental restorative materials. Pairs of molar teeth were set into occlusion with a weighted maxillary tooth mounted onto a vertical sliding assembly and the mandibular tooth supported by a load cell. The load components on the mandibular tooth were measured with three opposing pairs of dental restorative materials (plastic denture, all-ceramic and stainless steel), four (human and 3 artificial) salivas, and 16 occlusal configurations. All lateral force component measurements were significantly different (P<0.0001) from the dry (control) surface regardless of the crown material or occlusal configuration, while the effects of the artificial salivas compared to each other and to human saliva depended on the crown material.

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Section: Discussionsupporting

confidence: 46%

The effects of salivas on occlusal forces

McCrea

Katona

Eckert

2014

J of Oral Rehabilitation

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“…Corroborating this view are several in vitro studies that have examined the properties of salivary substitutes that contain mucin as well as a recent clinical trial in which the efficacy of a mucin containing artificial saliva was evaluated. Both the viscosity 42 and wetting properties 43 of salivary substitutes augmented with animal mucins more closely approximated for values obtained for the human salivary secretions. In a double-blind crossover clinical trial it was determined that a salivary substitute that contained animal mucin was found to be significantly better at relieving the subjective clinical complaints of xerostomia.…”

Section: B Lubricationsupporting

confidence: 53%

Structure And Function of Human Salivary Mucins

Tabak

1990

Critical Reviews in Oral Biology & Medicine

100

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“…No estudo de Thomsom et al 15 , é relatado que pacientes com alterações psiquiátricas que fazem uso deste fármaco queixam-se de boca seca. Ainda com relação ao aparecimento deste achado, é sabido que as glândulas submandibulares e sublinguais são responsáveis pela produção de mucina, produto responsável por promover a sensação de lubrificação da mucosa [16][17] . Foi constatado que a glândula submandibular mostra-se mais susceptível às perturbações causadas pelos medicamentos 18 .…”

Section: Discussionunclassified

Efeitos do metilfenidato sobre as glândulas salivares maternas de camundongos

Lima

Salles

Costa

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: O metilfenidato (MFD) é um derivado anfetamínico estimulante do sistema nervoso central, que vem sendo cada vez mais consumido pela população mundial, incluindo as mulheres em idade fértil. Ainda não foram estabelecidos os efeitos deste medicamento nas glândulas salivares, durante a gestação. Objetivo: Identificar alterações histomorfológicas em glândulas salivares maternas expostas ao metilfenidato. Material e método: Para análise histológica, foram utilizadas 32 fêmeas de camundongos Swiss prenhes, distribuídas em um grupo controle e um grupo tratado. A administração foi realizada do quinto ao 17º dia de gestação, via injeção subcutânea; o grupo tratado recebeu 5 mg/kg de metilfenidato, enquanto o grupo controle recebeu o mesmo volume de solução salina estéril. As fêmeas foram eutanasiadas e tiveram suas glândulas salivares removidas e incluídas em parafina para análise em microscopia óptica. Para avaliar a associação entre as variáveis dos grupos, o teste de Kolmogorov-Smirnov e o teste T foram utilizados. Resultado: As glândulas parótidas do grupo tratado apresentaram alterações no raio dos ductos e na quantidade de ácinos, quando comparadas às glândulas parótidas do grupo controle. A glândula submandibular do grupo tratado foi a mais afetada: mostrou diferença estatisticamente significativa na espessura da parede dos ductos secretores, no raio dos ductos e no raio dos ácinos, quando comparada à glândula submandibular do grupo controle. A glândula sublingual não apresentou alterações significativas. Conclusão: Neste delineamento experimental, o metilfenidato apresentou-se como agente indutor de alterações morfológicas das glândulas salivares, promovendo alterações significativas nos raios de ductos e ácinos das mesmas, sendo a glândula submandibular a mais susceptível a este fármaco.Descritores: Metilfenidato; glândulas salivares; gestação. AbstractIntroduction: Methylphenidate (MFD) is a stimulant amphetamine derivative of the central nervous system, which is being increasingly consumed by the world population, including women of childbearing age. It has not yet established the effects of this medicine in the salivary glands during pregnancy. Objective: Evaluate the exposure effects to the MPD in the maternal salivary glands. Material and method: For prenatal study, 32 pregnant female Swiss mice were used, divided into a control and a treated group. The treated group received 5 mg/kg of MPD via subcutaneous injection from the 5th to the 17th day and the control received sterile saline in the same volume and pregnancy period. Females were euthanized and had their salivary glands removed and embedded in paraffin for analysis in optical microscopy. To evaluate the association between the variables of the groups, the Kolmogorov-Smirnov test and and T test were used. Result: The parotid glands of the treated group showed statistically significant change within the ducts and the amount of acini when compared to the control group. The submandibular gland was the most affected, it showed a differe...

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Rheological properties of saliva substitutes containing mucin, carboxymethylcellulose or polyethylenoxide

Cited by 101 publications

References 9 publications

The effects of salivas on occlusal forces

The effects of salivas on occlusal forces

Structure And Function of Human Salivary Mucins

Efeitos do metilfenidato sobre as glândulas salivares maternas de camundongos

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