Rheological Properties of Erythrocytes and Lipid Profiles of Blood Plasma

Katiukhin, L. N.

doi:10.5171/2015.563217

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…This study revealed that atherogenic lipids increased erythrocyte's aggregation, but not erythrocyte deformability. (17) The increase in MCV was significant in diabetic males and insignificant in diabetic females (9) and there was correlation between HbA1c and MCHC in diabetic subjects (18). In the present study, we found that only MCV was correlated significantly with FPG, PPG, HbA1c and HOMA-IR.…”

Section: Laboratory Assaysmentioning

confidence: 99%

The Correlation between Glycemic Characteristic and Erythrocyte Indices in Obesity

Lindarto¹,

Syafril²,

Gatot³

2016

Indones Biomed J

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BACKGROUND: Elevated blood glucose level is a major factor in development of diabetic complications due to unfavorable hyperglycemic induced biochemical as well as hematological indices changes. The aim of this study was to evaluate the correlation between glycemic characteristic and erythrocyte indices in obese subjects with different glycemic status.METHODS: Cross cross-sectional study was designed, and 80 obese subjects were enrolled. The correlations between glycemic characteristic (fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c) and homeostasis model assessment of insulin resistance (HOMA-IR)) and erythrocyte indices (Hb, red blood count (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC)) were evaluated.RESULTS: Of 80 obese subjects with different glycemic status, there were 48 patients with only obesity (HbA1c <5.7%), 19 patients with pre-diabetes (HbA1c 5.7-6.4%) and 13 patients with diabetes (HbA1c >6.4%). Glycemic characteristic and profile lipid (high-density lipoprotein cholesterol (HDL-C), triglycerides (TG)) were differ significantly in the different HbA1c level. Erythrocyte indices were not differ significantly in the different HbA1c level. Partial Spearman's correlation analysis showed that only MCV was significantly correlated with glycemic characteristic of FPG, PPG, HbA1c and HOMA-IR (r=-0.36, p=0.001; r=-0.29, p=0.007; r=-0.27, p=0.014 and r=-0.236, p=0.035; respectively).CONCLUSION: MCV was significantly correlated with glycemic characteristic (FPG, PPG, HbA1C and HOMAIR). Further investigations are recommended.KEYWORDS: MCV, glycemic-characteristic, HbA1c, erythrocyte indices

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Section: Laboratory Assaysmentioning

confidence: 99%