Rheological Properties and Reverse Micelles Conditions of PEO-PPO-PEO Pluronic F68: Effects of Temperature and Solvent Mixtures

Henda, M. Ben; Ghaouar, N.; Gharbi, A.

doi:10.1155/2013/768653

Cited by 14 publications

(7 citation statements)

References 40 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, step 2 Inset). This is due to F-68's ability to form reverse micelles, which drastically increases the solubility of water in DCM (26). In the absence of F-68, the poor solubility of water in DCM limits the extent to which this process occurs (S H2O in DCM = 0.2 wt%; Fig.…”

Section: Resultsmentioning

confidence: 99%

Oxygen delivery using engineered microparticles

Seekell

Lock

Peng

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

A continuous supply of oxygen to tissues is vital to life and interruptions in its delivery are poorly tolerated. The treatment of low-blood oxygen tensions requires restoration of functional airways and lungs. Unfortunately, severe oxygen deprivation carries a high mortality rate and can make otherwise-survivable illnesses unsurvivable. Thus, an effective and rapid treatment for hypoxemia would be revolutionary. The i.v. injection of oxygen bubbles has recently emerged as a potential strategy to rapidly raise arterial oxygen tensions. In this report, we describe the fabrication of a polymerbased intravascular oxygen delivery agent. Polymer hollow microparticles (PHMs) are thin-walled, hollow polymer microcapsules with tunable nanoporous shells. We show that PHMs are easily charged with oxygen gas and that they release their oxygen payload only when exposed to desaturated blood. We demonstrate that oxygen release from PHMs is diffusion-controlled, that they deliver approximately five times more oxygen gas than human red blood cells (per gram), and that they are safe and effective when injected in vivo. Finally, we show that PHMs can be stored at room temperature under dry ambient conditions for at least 2 mo without any effect on particle size distribution or gas carrying capacity.hypoxemia | microparticle | oxygen | core-shell | colloids

show abstract

Section: Resultsmentioning

confidence: 99%

Oxygen delivery using engineered microparticles

Seekell

Lock

Peng

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The process therefore results in the selfassembly of particles with PEO coronas and PPO cores. 25 Above 1% PF-68 concentration the surface tension was not further changed (2.5% PF-68, 5% PF-68, 7.5 PF-68, 10% PF-68 and 20% PF-68) (Fig. 1a).…”

Section: Development and Characterization Of Pluronic F-68 Based (W)/mentioning

confidence: 89%

“…As a result, the hydrophilic segments of PF-68 form a polar cavity and stimulate the rearrangement of PF-68 to particles to inverse micellar particles. Ben Henda et al 25 studied PF-68 micelles in polar and non-polar solvents. In case of binary mixtures, the hydrophobic solvents (phenol and p-xylene) resulted in the inhibition of micelle selfassembly or formation of various types of inverse micelles.…”

Section: Development and Characterization Of Pluronic F-68 Based (W)/mentioning

confidence: 99%

Emulsion centrifugal spinning for production of 3D drug releasing nanofibres with core/shell structure

et al. 2017

View full text Add to dashboard Cite

show abstract

“…) is an amphiphilic copolymer having both hydrophobic (polypropylene (PPO)) and hydrophilic (poly-(ethylene oxide) (PEO)) groups. 1 The PPO segments assemble together to form the core region whereas the PEO segments form the corona region of the polymeric micelle of PF127. Different regions of the PF127 micelle are represented in Figure 3.…”

mentioning

confidence: 99%

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Mishra

Swain

2017

J. Phys. Chem. B

View full text Add to dashboard Cite

The thermoreversible sol-gel transition of pluronic F127 is markedly altered even with addition of submicellar concentration of sodium dodecyl sulfate (SDS) surfactant. Multiple fluorescence parameters like fluorescence intensity, fluorescence anisotropy and fluorescence lifetime of both the prototropic forms (anion (A*) and phototautomer FT*) of the photoprototropic fluorescent probe fisetin has been efficiently used to understand the molecular level properties like polarity and microviscosity of the PF127-SDS system as a function of temperature. The SDS-induced increase in the interfacial hydrophobicity level is seen to affect the sol-gel phase transition of PF127 (21-18 °C). The E(30) polarity parameter value of anionic emission of fisetin suggests that there is a considerable decrease in the polarity of the PF127 medium with increase in temperature and with the addition of SDS. The microviscosity progressively increases from ∼5 mPa s (sol state, 10 °C) to ∼22.01 mPa s (gel state 35 °C) in aqueous solution of PF127. The variation in microviscosity with addition of SDS in PF127-SDS mixed system is significant in sol phase whereas in gel phase this variation is significantly less. Temperature dependent fluorescence lifetime of FT* indicates that there is heterogeneity in distribution of fisetin molecules at different domains of PF127. This work also show-cases the sensitivity of fisetin toward change in polarity and change in sol-gel transition temperature of copolymer PF127 with variation in temperature (both forward and reverse directions) and SDS.

show abstract

Rheological Properties and Reverse Micelles Conditions of PEO-PPO-PEO Pluronic F68: Effects of Temperature and Solvent Mixtures

Cited by 14 publications

References 40 publications

Oxygen delivery using engineered microparticles

Oxygen delivery using engineered microparticles

Emulsion centrifugal spinning for production of 3D drug releasing nanofibres with core/shell structure

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Contact Info

Product

Resources

About