Emulsion centrifugal spinning for production of 3D drug releasing nanofibres with core/shell structure

Abstract

Herein we describe the core/shell centrifugal spinning process to deliver susceptible bioactive molecules.

Needleless emulsion electrospinning for the regulated delivery of susceptible proteins

“…This effect was confirmed by the improvement in HRP activity protection in the PCL‐5% PF‐68 group. The results are in accordance with our previous study on emulsion centrifugal spinning (Buzgo et al, ). The practical importance of protein stabilization and improved bioactivity is in the improved efficiency of protein‐based therapies.…”

“…With the increase in surfactant concentration, the molecules are on both the interface and the proteins. However, the proteins are still located on the liquid interface and in our case could be in contact with non‐polar solvents (Buzgo et al, ; Lee et al, ). As mentioned above, in the case of 1% PF‐68, the CMC was not reached.…”

PA6 Nanofibre Production: A Comparison between Rotary Jet Spinning and Electrospinning

“…Many reviews [2][3][4][5] into nanofibres have been published which investigate ever more uses for these amazing materials from many production methods. The applications that show significant promise for these materials include biomedical applications (drug delivery and tissue engineering scaffolds) [6][7][8][9], energy storage devices (lithium ion batteries) [10][11][12], and also air and water filtration applications [13][14][15]. Polymer nanofibres possess a very high surface area to volume ratio resulting in attractive applications where this property is advantageous.…”

Rotary jet spinning review – a potential high yield future for polymer nanofibers

“…104,[108][109][110][111] By being able to provide a predictable and controlled drug release over time by exploiting the high volume to surface area of nanofibers, one such study by Wang et al using RJS has shown that producing aligned fiber mats are preferable when designing for a slower and more controlled release of drugs, rather than a more rapid release for random oriented fibers due to the increased aqueous interaction. In their research, a lab-built device was used to produce polyvinylpyrrolidone (PVP) fibers between 6 and 19 microns in size via electro RJS.…”

“…Manufacturing fibers in the nano scale is of great interest for composites, as these fibers have a high aspect ratio and large available fiber surface area, potentially leading to high in the design of tissue engineering scaffolds is to mimic the natural interfaces that interact selectively with a specific cell type through biomolecular recognition. 103,104 Similar to tissue scaffolds, wound dressings are another biomedical application which has seen much focus, exploiting high surface areas within the nanofibers to foster the perfect conditions for cell growth, embryologic development, organogenesis, and wound repair. 105,106 Using RJS nanofibers in direct contact with the human body is only one aspect of the biomedical applications of nanofibers.…”