Rheological characterization of new thermosensitive hydrogels formed by chitosan, glycerophosphate, and phosphorylated β-cyclodextrin

Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis

“…Polymer blends provide a simple approach to combine the advantages of different polymers, for example adhesiveness and environmental responsiveness (Barbosa et al, 2017;Borghi-Pangoni et al, 2015;Bruschi et al, 2007;Jones et al, 2009;Liu, Lin, Li, & Liu, 2005). Thermoresponsive gelling systems have been widely studied over the years for drug delivery, mainly due to their ease of application, spreadability and retention at the application site (de Francisco et al, 2019;Ramírez Barragán et al, 2018). Moreover, where these thermoresponsive materials are composed of nanostructured micelles derived from amphiphilic block copolymers they may improve solubilization, stabilization and control of drug delivery (Jindal & Mehta, 2015).…”

Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction

“…The hydrogel preparation was fabricated by the previously reported methods. 41 - 43 In this examination, the 3 components of the CD@β-GP hydrogels as below. The C solution was synthesized by the dissolving of C (150 mg) in 7 mL acetic acid solution under RT.…”

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

“…This route can be used for any age category, but especially in children and the elderly or unconscious people [ 3 , 4 , 103 ], without the need for qualified staff [ 9 , 61 ]. Nasal administration has other advantages: It is not painful [ 60 ], it does not require sterilization [ 9 ], it is non-invasive [ 61 ], parenteral administration can be avoided (e.g., for insulin) [ 3 , 4 , 103 ], and it increases the patient’s adhesion to treatment [ 9 ]. Enzymatic and acidic degradation in the gastrointestinal tract is prevented by the nasal administration of drugs (e.g., insulin) [ 106 ] and the effect of systemic dilution is minimized [ 104 ].…”

“…The development of thermo-sensitive hydrogels, which are administered in the nasal route and which pass from the soil phase at room temperature to the gel phase when they reach body temperature is constantly advancing [ 3 , 103 , 116 ]. A hydrogel based on chitosan and β-glycerophosphate is a thermo-sensitive one [ 3 , 118 ]. This type of hydrogel is used for the nasal administration of doxepine, bypassing BBB [ 119 ].…”

“…Chitosan, the second most common natural polysaccharide [ 1 , 2 , 3 , 4 ] and the only polycationic polysaccharide extracted from bio sources, is obtained from chitin by N -deacetylation [ 5 ]. The sources of chitin are crustaceans (crabs and shrimps), cephalopods [ 2 ], cuttlefish [ 5 ], insects (spiders, beetles, and ants) [ 3 , 6 ], fungi [ 1 , 3 , 4 ], spores [ 6 ], protozoa [ 2 ], yeasts [ 7 ], and algae [ 2 , 6 ]. Chitosan is a polymeric polysaccharide [ 5 ] ( Figure 1 ) with a linear structure [ 8 ], is unbranched [ 9 ] and flexible [ 5 ], and has a high nitrogen content [ 6 ].…”