Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer

Luukkonen, Pirjo; Schæfer, Torben; Hellén, Leena; Juppo, Anne; Yliruusi, Jouko

doi:10.1016/s0378-5173(99)00219-7

Cited by 61 publications

(25 citation statements)

References 19 publications

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“…The plotted curve represents different states of liquid saturation. The peak region in the curve corresponds to the capillary state of liquid saturation (16).…”

Section: Moistened Mass Rheological Studiesmentioning

confidence: 99%

Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion–Spheronization

Sarkar

Liew

2014

AAPS PharmSciTech

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Abstract. The wet-state particle size of microcrystalline cellulose (MCC) dispersed in different moistening liquids was characterized to elucidate the effect of moistening liquid type on the extent of MCC particle deaggregation. Cohesive strength of moistened MCC masses was also assessed and pellet production by extrusion-spheronization attempted. MCC dispersed in alcohol or water-alcohol mixtures with higher alcohol proportions generally had larger particle sizes. Moistened mass cohesive strength decreased and poorer quality pellets were obtained when water-alcohol mixtures with higher alcohol proportions were used as the moistening liquid. MCC comprise aggregates of small sub-units held together by hydrogen bonds. As MCC particle de-aggregation involves hydrogen bond breaking, moistening liquids with lower polarity, such as water-alcohol mixtures with higher alcohol proportions, induced lesser de-aggregation and yielded MCC with larger particle sizes. When such water-alcohol mixtures were employed during extrusion-spheronization with MCC, the larger particle size of MCC and lower surface tension of the moistening liquid gave rise to moistened masses with lower cohesive strength. During pelletization, agglomerate growth by coalescence and closer packing of components by particle rearrangement would be limited. Thus, weaker, less spherical pellets with smaller size and wider size distribution were produced.

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“…The plotted curve represents different states of liquid saturation. The peak region in the curve corresponds to the capillary state of liquid saturation (16).…”

Section: Moistened Mass Rheological Studiesmentioning

confidence: 99%

Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion–Spheronization

Sarkar

Liew

2014

AAPS PharmSciTech

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“…Earlier reported SSA values for unmodified MCCs vary ranging from 0.23 [55] up to 1.44 m 2 g -1 [56]. Surface area values ranging from 4.91 [57] to 6.34 m 2 g -1 [58] have been reported for surfacemodified (Silicified) MCCs, but these are significantly below the levels measured for the never-dried MCC, DP390.…”

Section: Discussionmentioning

confidence: 88%

Microcrystalline cellulose property–structure effects in high-pressure fluidization: microfibril characteristics

et al. 2016

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The raw material properties and characteristics of four different microfibrillated celluloses (MFCs) produced by microfluidizing were investigated. The cellulose materials were never-dried and dried microcrystalline cellulose (MCC), a commercial MCC, and an enzymatic-mechanically treated softwood sulfite pulp. The study comprises extensive initial and final physical, structural, and molecular-level analyses. The results indicated that raw material properties related to both fibril aggregation, structural compaction levels and geometric heterogeneity and interaction levels essentially affected both the process and the final MFC properties. The increase in specific surface area (SSA) was minor for the enzymatic-mechanically treated raw material, while MCC showed a larger increase of several orders of magnitude in SSA. The drying of particulate MCC was reflected both in improved fibrillation efficiency and in the final MFC properties, primarily observed as enhanced SSA, in fibril dimensions and in gel strength. The feed consistency (7.5 %) applicable with dried, particulate MCC in fluidization was more than any of those hitherto reported. The study indicated that MCC can facilitate energy-efficient MFC production with the application of fluidization technology.

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“…Silicon dioxide simply adheres to the surface of MCC and occurs mainly on the surface of MCC particles; only a small amount was detected in the internal regions of the particles. So, SMCC shows higher bulk density than the common types of MCC [75]. Also, tensile strength of compacts of SMCC is greater than that of the respective MCC [76] and it is most probably a consequence of intersurface interactions of silicon dioxide and MCC [77].…”

Section: Microcrystalline Cellulosementioning

confidence: 98%

Pharmaceutical significance of cellulose: A review

Kamel¹,

Ali²,

Jahangir³

et al. 2008

Express Polym. Lett.

374

191

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Abstract. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets. Cellulose acetate phthalate and hydroxymethyl cellulose phthalate are also used for enteric coating of tablets. Targeting of drugs to the colon following oral administration has also been accomplished by using polysaccharides such as hdroxypropylmethyl cellulose and hydroxypropyl cellulose in hydrated form; also they act as binders that swell when hydrated by gastric media and delay absorption. This paper assembles the current knowledge on the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for pharmaceuticals.

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Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer

Cited by 61 publications

References 19 publications

Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion–Spheronization

Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion–Spheronization

Microcrystalline cellulose property–structure effects in high-pressure fluidization: microfibril characteristics

Pharmaceutical significance of cellulose: A review

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