Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion

Abstract

Pterodon pubescens, popularly known as "sucupira", it is traditionally used as anti-inflammatory agent. This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system. The viscoelastic properties, creep and recovery were evaluated by dynamic oscillatory tests. The antiarthritic activity of the nanoemulsion was evaluated by the zymozan-induced arthritis model, at three different doses (25, 50 and 125 mg/kg/day). P. pubescens oil nanoemulsion has been shown to decrease cell recruitment to a joint cavity and increased cartilaginous regeneration at the end of treatment of the dose of 50 mg/kg. The evaluation of the behaviour of deformation allowed to observe that the P. pubescens nanoemulsion presents predominantly elastic characteristic. These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs.

Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

“…To assess their efficiency and safety, another study by the same group [ 139 ], evaluated the anti-inflammatory activities of NE in a model of carrageenan-induced peritonitis. The NE containing ethanolic extracts of P. pubescens showed a significant inhibitory effect on leukocyte migration, even after 1 year of storage, indicating potential use in anti-inflammatory therapies, as well as in the treatment of arthritis [ 142 ]. The anti-inflammatory potential of the oil extracted from the fruits of P. emarginatus and encapsulated in microemulsions was evaluated in the ear edema model induced by the topical application of croton oil [ 140 ].…”