Rheological and Viscoelastic Properties of Novel Sunflower Oil‐Span 40‐Biopolymer–Based Bigels and Their Role as a Functional Material in the Delivery of Antimicrobial Agents

Abstract

ABSTRACT:In this paper, the mechanical properties of sunflower oil-span 40-natural gum bigels were evaluated. The bigels were prepared by mixing the oleogels of sunflower oil-span 40 and the hydrogels of natural gums. The types of molecular interactions occurring were studied by FTIR spectroscopy. Rheological and textural behavior of the bigels was determined by dynamic rheological studies and a static mechanical tester. The Peleg and Normand equation was used to determine the viscoelastic behavior of the bigels. The efficiency of these food-grade bigels as carriers for the delivery of metronidazole (model drug) was studied. In vitro drug release was carried out under physiological conditions. The antimicrobial efficiency of the bigels was checked against Escherichia coli. FTIR studies showed hydrogen bonding within the bigels as the major molecular interaction. The rheological and mechanical studies showed that the bigels exhibited pseudoplastic flow behavior. The bigels were viscoelastic in nature. Diffusion mediated drug release was observed. All the bigels showed an equal antimicrobial efficacy in comparison to the available marketed formulation. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21488; View this article online at wileyonlinelibrary.com.

Modulating process parameters to change physical properties of bigels for food applications

“…Mechanical parameters (e.g. hardness, spreadability, adhesiveness) were dependent on the composition, as reported previously by other authors (Almeida et al, 2008;Behera, Dey et al, 2015;Rehman & Zulfakar, 2017), and process parameter. In our work, these parameters were consistent with the rheological results for the gels produced.…”

“…Guar gum (Sahoo et al, 2015;Vinay K. Singh, Banerjee et al, 2014), gelatin (Sai Sateesh Sagiri, Singh, Kulanthaivel et al, 2015;Satapathy et al, 2015), gelatin-agar mixture (Wakhet et al, 2015), sodium alginate (Rehman, Mohd Amin, & Zulfakar, 2014) starch (Behera, Sagiri, Singh, Pal, & Anis, 2014) and synthetic polymers (PVA and PVP) (Behera, Singh et al, 2015) are examples of hydrocolloids used. In the same way, sorbitan monopalmitate and sunflower oil (Behera, Dey, Sharma, & Pal, 2015), sorbitan monostearate and sesame oil (Vinay K. Singh, Anis et al, 2014;Vinay K. Singh, Banerjee et al, 2014), policosanol from rice bran wax and glyceril stearate with extra virgin olive oil (Lupi et al, 2016) and medium chain triglycerides with beeswax (Martins et al, 2019) were some of the studied organogels.…”

Enzymatic synthesis and self-assembly of glycolipids: robust self-healing and wound closure performance of assembled soft materials

“…In addition, the antioxidant property displayed by ascorbic acid is responsible for diminution of macrophages, increased proliferation of broblasts, blood vessel repair and immunological defence. [72][73][74][75][76][77][78][79] In the present study, elevated content of ascorbic acid in the oleogel 2-treated rats was observed when compared with that of oleogel 1-treated, composite geltreated, control and untreated rats. It is important to mention that the presence of curcumin in the composite gel has less effect on ascorbic acid production in the wound area.…”

Bi-Gels: A Novel Material for Transdermal Drug Delivery

“…Higher viscosity system containing higher molecular weight-branched chain polymer and higher concentration of organogellator. Higher the concentration of hydrogel results to decreases the viscosity of the bi-gel system [35].…”