Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-Based Injectable Bone Substitutes

Oğuz, Öznur Demir; Ege, Duygu

doi:10.3390/ma11040604

Cited by 26 publications

(10 citation statements)

References 60 publications

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“…Comparing these results with other cellulose-derived hydrogels loaded with calcium phosphate, TOCNFs CaP and TOCNFs CaPGO show a broader LVR. In contrast, the storage modulus values recorded are lower compared with the average G' values found in these studies [34][35][36]. This is probably a consequence of the higher inorganic content considered.…”

Section: Injectability Testcontrasting

confidence: 77%

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

et al. 2021

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Cellulose represents a low cost, abundant, and renewable polysaccharide with great versatility; it has a hierarchical structure composed of nanofibers with high aspect ratio (3–4 nm wide, hundreds of μm long). TEMPO-mediated oxidation represents one of the most diffused methods to obtain cellulose nanofibers (CNFs): It is possible to obtain physically crosslinked hydrogels by means of divalent cation addition. The presence of inorganic components, such as calcium phosphates (CaP), can improve not only their mechanical properties but also the bioactivity of the gels. The aim of this work is to design and characterize a TEMPO-oxidized cellulose nanofibers (TOCNFs) injectable hydrogel embedded with inorganic particles, CaP and CaP-GO, for bone tissue regeneration. Inorganic particles act as physical crosslinkers, as proven by rheological characterization, which reported an increase in mechanical properties. The average load value registered in injection tests was in the range of 1.5–4.4 N, far below 30 N, considered a reasonable injection force upper limit. Samples were stable for up to 28 days and both CaP and CaP-GO accelerate mineralization as suggested by SEM and XRD analysis. No cytotoxic effects were shown on SAOS-2 cells cultured with eluates. This work demonstrated that the physicochemical properties of TOCNFs-based dispersions could be enhanced and modulated through the addition of the inorganic phases, maintaining the injectability and bioactivity of the hydrogels.

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Section: Injectability Testcontrasting

confidence: 77%

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

et al. 2021

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“…5 mL) of the solution was used for the measurement, and the rest was used for aerogel preparation. Two types of measurements, time sweep test and temperature sweep test, were performed according to the previously reported method with slight modifications (Oguz and Ege 2018). The time sweep test was performed at a constant temperature of 20°C and an angular frequency of 6.28 rad/s.…”

Section: Rheological Properties Of the Cellulose Solutionmentioning

confidence: 99%

Tuning the morphological properties of cellulose aerogels: an investigation of salt-mediated preparation

et al. 2021

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In this study, alkali and alkaline earth metal chlorides with different cationic radii (LiCl, NaCl, and KCl, MgCl2, and CaCl2) were used to gain insight into the behavior of cellulose solutions in the presence of salts. The specific focus of the study was on the evaluation of the effect of salts’ addition on the sol–gel transition of the cellulose solutions and on their ability to form monoliths, as well as the evaluation of the morphology (e.g., specific surface area, pore characteristics, and microstructure) of aerocelluloses prepared from these solutions. The effect of the salt addition on the sol–gel transition of cellulose solutions was studied using rheology, and morphology of resultant aerogels was evaluated by scanning electron microscopy and Brunauer–Emmett–Teller analysis, while the salt influence on the aerocelluloses’ crystalline structure and thermal stability was evaluated using powder X-ray diffraction and thermogravimetric analysis, respectively. The study revealed that the effect of salts’ addition was dependent on the component ions and their concentration. The addition of salts in the amount below certain concentration limit significantly improved the ability of the cellulose solutions to form monoliths and reduced the sol–gel transition time. Salts of lower cationic radii had a greater effect on gelation. However, excessive amount of salts resulted in the formation of fragile monoliths or no formation of gels at all. Analysis of surface morphology demonstrated that the addition of salts resulted in a significant increase in porosity and specific surface area, with salts of lower cationic radii leading to aerogels with much larger (~ 1.5 and 1.6-fold for LiCl and MgCl2, respectively) specific surface area compared to aerocelluloses prepared with no added salt. Thus, by adding the appropriate salt into the cellulose solution prior to gelation, the properties of aerocelluloses that control material’s performance (specific surface area, density, and porosity) could be tailored for a specific application. Graphic abstract

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“…The thermo-responsive hydrogel from kappa-carrageenan and methylcellulose showed double thermal gel-sol-gel transition upon heating and was used for developing the drug delivery system [70]. The injectable bone substitute was prepared from the thermo-responsive hydrogel of methylcellulose, gelatin, and citric acid with a bio-ceramic powder loaded into it [71]. The injectable thermosensitive hydrogel from methylcellulose and chitosan was applied for tissue engineering and showed sol-gel transition near the body temperature of 37 °C [72].…”

Section: Natural Stimuli-responsive Polymersmentioning

confidence: 99%

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

2019

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This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis.

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Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-Based Injectable Bone Substitutes

Cited by 26 publications

References 60 publications

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

Tuning the morphological properties of cellulose aerogels: an investigation of salt-mediated preparation

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

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