Rhein and polydimethylsiloxane functionalized carbon/carbon composites as prosthetic implants for bone repair applications

Jia, Zhenzhen; Yang, Chen; Jiao, Jiajia; Li, Xinyu; Zhu, Dashuai; Yang, Yongchao; Yang, Jingyi; Che, Yongzhe; Lü, Yun

doi:10.1088/1748-605x/aa6e27

Cited by 9 publications

(10 citation statements)

References 40 publications

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“…As a universal IEE platform, the AECD also has various other applications. For example, it could also potentially be used to treat urinary incontinence; if integrated with a strain sensor, the AECD could monitor the bladder function, and when pathological behavior occurs, it could electrically stimulate the bladder sensory afferents to normalize bladder function ( 71 ). After specific programming, the AECD can undertake any programmed action when facing various physiologic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…We used APT to implement wireless energy transfer and communication, taking into consideration the high biocompatibility of the AECD with the human body. The inner components are fully sealed by PDMS, which has high biocompatibility (71), and some scholars have demonstrated that these electronic devices encapsulated by PDMS have high hemocompatibility, low inflammation, and long-term usage potential (71)(72)(73). In addition, the PDMS materials also have strong biodurability, because scholars have tested that implants made of these materials would not fail within 32 years (74).…”

Section: Introductionmentioning

confidence: 99%

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A flexible, stretchable system for simultaneous acoustic energy transfer and communication

Jin

Wang

et al. 2021

Sci. Adv.

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The use of implantable medical devices, including cardiac pacemakers and brain pacemakers, is becoming increasingly prevalent. However, surgically replacing batteries owing to their limited lifetime is a drawback of those devices. Such an operation poses a risk to patients-a problem that, to date, has not yet been solved. Furthermore, current devices are large and rigid, potentially causing patient discomfort after implantation. To address this problem, we developed a thin, battery-free, flexible, implantable system based on flexible electronic technology that can not only achieve wireless recharging and communication simultaneously via ultrasound but also perform many current device functions, including in vivo physiological monitoring and cardiac pacing. To prove this, an animal experiment was conducted involving creating a cardiac arrest model and powering the system by ultrasound. The results showed that it automatically detected abnormal heartbeats and responded by electrically stimulating the heart, demonstrating the device's potential clinical utility for emergent treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A flexible, stretchable system for simultaneous acoustic energy transfer and communication

Jin

Wang

et al. 2021

Sci. Adv.

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“…Piezoelectric materials can generate electrical signals in response to mechanical stress , and can, therefore, stimulate the signaling pathways and promote tissue regeneration in the impaired sites, indicating that the application of piezoelectric materials in bone regeneration is feasible. , Piezoelectric materials can be classified into piezoelectric polymers and ceramics, such as poly(vinylidene fluoride) (PVDF), poly(vinylidene fluoridetrifluoroethylene) (PVDF-TrFE), polydimethylsiloxane (PDMS), and BaTiO 3 (barium titanate) . Piezoelectric polymers generally present superior biocompatibility, excellent cell adhesion, and growth facilitation.…”

Section: Introductionmentioning

confidence: 99%

Piezoelectric PDMS/AlN Film for Osteogenesis in Vitro

Tang

et al. 2023

ACS Biomater. Sci. Eng.

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Bone defect and nonunion are complex diseases which are difficult to treat due to insufficient bone regeneration. Electrical stimulation has attracted attention as a promising strategy to induce and enhance bone regeneration. Self-powered and biocompatible materials have been widely explored and used in biomedical devices, owing to their ability to produce electrical stimulation without an external power source. We aimed to prepare a piezoelectric polydimethylsiloxane (PDMS)/aluminum nitride (AlN) film with excellent biocompatibility and osteoconductive ability for the growth of murine calvarial preosteoblast MC3T3-E1 cells. By applying vibration to stimulate body movement, the PDMS/ AlN film demonstrated a current density of 2−6 μA cm −2 , and the generated continuous alternating current (AC) effectively promoted MC3T3-E1 cell growth, viability, and osteoblastic related gene expression (genes runt-related transcription factor 2 [RUNX2], osteocalcin [OCN], alkaline phosphatase [ALP]) and exhibited higher mineralization. Compared to blank plates and nonvibrated PDMS/AlN films, the vibrated PDMS/AlN film showed rapid and superior osteogenic differentiation. The design of the biocompatible and flexible piezoelectric PDMS/AlN film overcame the poor processability, brittleness, and instability of electrical stimulation of traditional electroactive materials, demonstrating great potential in the application of electrical stimulation for bone tissue engineering.

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“…3 Therefore, surface modification of C/C composites has been extensively studied in the field of bone repair. 4,5 Many surface modification techniques have been used to prepare biomedical coatings and films of C/C composites, including plasma spraying, 6,7 electromagnetic deposition, 8 and magnetron sputtering. 9 Among them, polydopamine (PDA) coatings have attracted much interest due to the simple method of formation.…”

Section: Introductionmentioning

confidence: 99%

“…3 Therefore, surface modification of C/C composites has been extensively studied in the field of bone repair. 4,5…”

Section: Introductionmentioning

confidence: 99%

Dopamine-assisted immobilization of peptide arginine–glycine–aspartic acid to enhance the cellular performances of MC3T3-E1 cells of carbon–carbon composites

Yang

et al. 2019

J Biomater Appl

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Due to their excellent biocompatibility and suitable elastic modulus, carbon–carbon composites have excellent prospects for a wide range of applications such as artificial joints and bone replacements. However, the hydrophobicity and poor bioactivity limit their application in bone repair and substitution. Herein, a two-step surface modification of carbon–carbon composites was proposed to overcome these disadvantages. A polydopamine (PDA) layer was first deposited on the surface of carbon–carbon composites, followed by covalent coupling with arginine–glycine–aspartic acid (RGD) in varying concentrations. The surface-modified materials were characterized using a variety of techniques including water contact angle, scanning electron microscopy, atomic force microscopy, and protein adsorption. In addition, the cellular proliferation, alkaline phosphatase activity, and real-time quantitative PCR (RT-PCR) analysis were further tested in vitro. The results indicated that polydopamine and RGD nanoparticles formed on the surface, which significantly enhanced the hydrophilicity following modification. The RGD–PDA-coated carbon–carbon composites exhibited excellent roughness, protein adsorption behavior, and uniform morphology when a concentration of 50 µg/mL RGD was used, unlike blank and polydopamine-modified carbon–carbon composites. The in vitro cell co-culture experiments demonstrated that proliferation and alkaline phosphatase expression in osteoblasts was greatly improved after RGD–PDA coating. The RT-PCR results revealed that the expression of differentiation markers (alkaline phosphatase and osteocalcin) in cells on the RGD–PDA-coated carbon–carbon composites was higher than that on the blank and polydopamine-modified carbon–carbon composites, indicating that the RGD–PDA coating could support cell proliferation and promote osteogenic differentiation of MC3T3-E1 cells. In particular, the cells cultured on this material grew linearly along the morphological features of the material, which was effective for the subsequent regulation of cell growth. Our study suggested that the RGD–PDA coating was an effective method of enhancing the hydrophobicity and the cellular bioactivity of carbon–carbon composites, thus extending applications of carbon–carbon composites to the bone repair field.

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Rhein and polydimethylsiloxane functionalized carbon/carbon composites as prosthetic implants for bone repair applications

Cited by 9 publications

References 40 publications

A flexible, stretchable system for simultaneous acoustic energy transfer and communication

A flexible, stretchable system for simultaneous acoustic energy transfer and communication

Piezoelectric PDMS/AlN Film for Osteogenesis in Vitro

Dopamine-assisted immobilization of peptide arginine–glycine–aspartic acid to enhance the cellular performances of MC3T3-E1 cells of carbon–carbon composites

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