Piezoelectric PDMS/AlN Film for Osteogenesis in Vitro

Abstract

Bone defect and nonunion are complex diseases which are difficult to treat due to insufficient bone regeneration. Electrical stimulation has attracted attention as a promising strategy to induce and enhance bone regeneration. Self-powered and biocompatible materials have been widely explored and used in biomedical devices, owing to their ability to produce electrical stimulation without an external power source. We aimed to prepare a piezoelectric polydimethylsiloxane (PDMS)/aluminum nitride (AlN) film with excellent biocompatibility and osteoconductive ability for the growth of murine calvarial preosteoblast MC3T3-E1 cells. By applying vibration to stimulate body movement, the PDMS/ AlN film demonstrated a current density of 2−6 μA cm −2 , and the generated continuous alternating current (AC) effectively promoted MC3T3-E1 cell growth, viability, and osteoblastic related gene expression (genes runt-related transcription factor 2 [RUNX2], osteocalcin [OCN], alkaline phosphatase [ALP]) and exhibited higher mineralization. Compared to blank plates and nonvibrated PDMS/AlN films, the vibrated PDMS/AlN film showed rapid and superior osteogenic differentiation. The design of the biocompatible and flexible piezoelectric PDMS/AlN film overcame the poor processability, brittleness, and instability of electrical stimulation of traditional electroactive materials, demonstrating great potential in the application of electrical stimulation for bone tissue engineering.

Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds

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Bibliometric and Visualized Analysis of Piezoelectric Materials in Biomedical Application

“…Piezoelectric materials have the ability to capture mechanical energy from vibrations, human movement, and mechanical loads and convert it into distinctive electrical signals, showcasing their remarkable sensing capabilities. Biosensors that utilize piezoelectric materials have found extensive usage across various applications, including measuring cellular and tissue mechanical deformations, characterizing materials, and establishing medical monitoring systems. − In addition, piezoelectric materials can provide huge application opportunities in ultrasonic imaging, piezoelectric therapy, biosensors, drug delivery systems, and more. The use of piezoelectric materials in biomedicine is a rapidly expanding field of study.…”