RhBMP-7 improves survival and eruption in a growing tooth avulsion trauma model

Springer, Ingo N.; Açil, Yahya; Spies, Christian; Jepsen, Søren; Warnke, Patrick H.; Bolte, Hendrik; Kuchenbecker, Solveig; Russo, Paul; Wiltfang, Jens; Terheyden, Hendrik

doi:10.1016/j.bone.2005.04.037

Cited by 16 publications

(17 citation statements)

References 35 publications

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“…The mineralization of teeth is altered by different factors such as biological rhythms (Smith, 2006), age (Smith et al. 2006), and external influences like caries or trauma (Springer et al. 2005), hormonal (Kitahara et al.…”

Section: Discussionmentioning

confidence: 99%

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New advances in fluorochrome sequential labelling of teeth using seven different fluorochromes and spectral image analysis

Pautke

Tischer²,

Vogt³

et al. 2006

Journal of Anatomy

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Fluorochrome sequential labelling of mineralizing tissues is commonly used in different fields of clinical and basic research. Recently we improved polychrome fluorescent sequential labelling of bone by applying spectral image analysis to discriminate seven different fluorochromes. Although basic mineralization processes of bone and teeth follow comparable principles, the respective tissues differ in terms of matrix composition and mineral assembly.The aim of this study therefore was to investigate the feasibility of this new technique for polychrome sequential labelling of teeth and to demonstrate the advantages in the field of dentistry. Furthermore, the exact labelled area of each fluorochrome could be measured, even in regions of overlapping fluorochromes. The technique presented may provide a basis for further investigations of mineralization processes of different anatomical dental structures.

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Section: Discussionmentioning

confidence: 99%

“…In teeth it is used to investigate biological rhythms (Smith, 2006), rates of mineralization (Dean, 2000), chronological development and individual age (Smith et al. 2006), or pulpal response on external influences (Springer et al. 2005).…”

Section: Introductionmentioning

confidence: 99%

New advances in fluorochrome sequential labelling of teeth using seven different fluorochromes and spectral image analysis

Pautke

Tischer²,

Vogt³

et al. 2006

Journal of Anatomy

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“…Springer and colleagues found that the incorporation of bone morphogenetic protein-7 (BMP-7) into the tooth socket prior to replantation in minipigs improved the survival rate, but only when the PDL was partially traumatised. When there was minimal or total destruction of the PDL prior to replantation, there was no difference in survival rates amongst the control and BMP-7 groups [13]. In a series of studies performed by Sorensen et al [14] and Wikesjo et al [15] the topical application of bone morphogenetic protein-12 (BMP-12) to replanted teeth in Labrador mongrel dogs did not have an apparent effect on new cementum and PDL formation or on the presence and extent of ankylosis when compared to controls.…”

Section: Introductionmentioning

confidence: 99%

A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study

et al. 2014

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BackgroundThis study aims to investigate, utilising micro-computed tomography (micro-CT) and histology, whether the topical application of nerve growth factor (NGF) and/or epidermal growth factor (EGF) can enhance periodontal, alveolar bone, root and pulpal tissue regeneration while minimising the risk of pulpal necrosis, root resorption and ankylosis of replanted molars in a rat model.MethodsTwelve four-week-old male Sprague-Dawley rats were divided into four groups: sham, collagen, EGF and NGF. The maxillary right first molar was elevated and replanted with or without a collagen membrane impregnated with either the growth factors EGF or NGF, or a saline solution. Four weeks after replantation, the animals were sacrificed and the posterior maxilla was assessed using histological and micro-CT analysis. The maxillary left first molar served as the control for the corresponding right first molar.ResultsMicro-CT analysis revealed a tendency for all replanted molars to have reduced root length, root volume, alveolar bone height and inter-radicular alveolar bone volume. It appears that the use of the collagen membrane had a negative effect while no positive effect was noted with the incorporation of EGF or NGF. Histologically, the incorporation of the collagen membrane was found to negatively affect pulpal, root, periodontal and alveolar bone healing with pulpal inflammation and hard tissue formation, extensive root resorption and alveolar bone fragmentation. The incorporation of EGF and NGF did not improve root, periodontal or alveolar bone healing. However, EGF was found to improve pulp vascularisation while NGF-improved pulpal architecture and cell organisation, although not to the level of the control group.ConclusionsResults indicate a possible benefit on pulpal vascularisation and pulpal cell organisation following the incorporation of EGF and NGF, respectively, into the alveolar socket of replanted molars in the rat model. No potential benefit of EGF and NGF was detected in periodontal or root healing, while the use of a collagen membrane carrier was found to have a negative effect on the healing response.

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“…Despite, the widespread usage of autologous tissues for implantology and maxillofacial surgical procedures, the material research is still in progress. The role of Runx2 gene in bone formation has been demonstrated that manifest a complete absence of osteogenesis in deficient mice [4][5][6][7][8][9] and in the multiple skeletal abnormalities in patients with CCD associated with genetic mutations. Stem cell sorting showed the typical immunophenotypic characterization of mesenchymal stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…6 The alveolar bone resorption and remodeling processes produced a rapid loss of the normal maxillary or jawbone architecture. 9,10 Several clinical studies have been performed to evaluate the use of different autologous or heterologous biomaterials scaffolds. 9,10 Several clinical studies have been performed to evaluate the use of different autologous or heterologous biomaterials scaffolds.…”

mentioning

confidence: 99%

A Comparison of Bovine Bone and Hydroxyapatite Scaffolds During Initial Bone Regeneration

et al. 2013

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RhBMP-7 improves survival and eruption in a growing tooth avulsion trauma model

Cited by 16 publications

References 35 publications

New advances in fluorochrome sequential labelling of teeth using seven different fluorochromes and spectral image analysis

New advances in fluorochrome sequential labelling of teeth using seven different fluorochromes and spectral image analysis

A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study

A Comparison of Bovine Bone and Hydroxyapatite Scaffolds During Initial Bone Regeneration

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