Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant

Augustyn, Alexander; Alattar, Mona Lisa; Naina, Harris V.

doi:10.1155/2015/619473

Cited by 5 publications

(3 citation statements)

References 23 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ere are a number of case reports of RML following administration of theophylline [12,13]. A few case reports have reported co-trimoxazole as a potential trigger of RML [14,15]. Even though endogenous estrogen appears to attenuate muscle damage in animals, women taking oral contraceptives, thereby having higher exogenous estrogen levels with lower endogenous estrogen levels, appear to be more susceptible to exerciseinduced muscle damage and have an attenuated recovery from exercise-induced muscle damage [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature

Indika

Vidanapathirana

Jasinge

et al. 2020

Case Reports in Medicine

View full text Add to dashboard Cite

Phosphatidate phosphatase-1 (lipin-1) is encoded by LPIN1 gene. Lipin-1 deficiency has been reported as the second most common cause of early-onset rhabdomyolysis after primary fatty acid oxidation disorders. We report a case of a 32-year-old Sri Lankan female with a history of more than 10 episodes of rhabdomyolysis and exercise intolerance since childhood. These episodes were triggered by infections and exercise. A temporal relationship between the acute episodes and use of drugs such as theophylline, mefenamic acid, co-trimoxazole, and combined oral contraceptive pills was also noted. There was marked elevation of serum creatine kinase and transaminases during acute episodes. Family history revealed parental consanguinity and an affected sibling who died of an acute episode associated with muscle weakness, dark coloured urine, and cyanosis, at the age of 2 years. The histochemical findings of the patient under discussion were consistent with a metabolic myopathy affecting membrane integrity. A homozygous, likely pathogenic variant c.1684G>T encoding p.(Glu562∗) was identified by clinical exome sequencing. Even though the studies to date give no convincing evidence of a possible causal or contributory relationship between the drugs under discussion and lipin-1 related rhabdomyolysis, this case highlights the importance of pharmacovigilance and reporting adverse drug reactions in patients with lipin-1 deficiency.

show abstract

Section: Discussionmentioning

confidence: 99%

Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature

Indika

Vidanapathirana

Jasinge

et al. 2020

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…However, in the literature in English, there are reports indicating that dasatinib can be safely used in patients who have experienced rhabdomyolysis. 6 Augustyn et al 6 and our group had administered dasatinib to CML patients with rhabdomyolysis, and there were no complications, including CK increase, in the clinical and laboratory follow-up of the patients. Nevertheless, we agree with Uz and Dolasik that if there is rhabdomyolysis in a given CML patient who has been using imatinib, one of the second-generation TKIs (tyrosine kinase inhibitors), including nilotinib, could be administered to the patient.…”

mentioning

confidence: 75%

Reply

Malkan¹,

Güneş²,

Etgül³

et al. 2016

Ann Pharmacother

View full text Add to dashboard Cite

“…Our review of the literature found most of the reported cases being in immunocompromised patients with HIV infection [10] [11] [12], or allogeneic stem cell transplant recipient [11] [13]. To the best of our knowledge, our patient is the third case of SMX-TMP-induced rhabdomyolysis in an immunocompetent patient, and the second of the immunocompetent patient to have multiple attributing factors [14] [15].…”

Section: Introductionmentioning

confidence: 86%

Sulfamethoxazole-Trimethoprim-Induced Rhabdomyolysis in an Immunocompetent Patient: A Case Report

Moye¹,

Manasen²,

O’Brien³

2017

CRCM

View full text Add to dashboard Cite

Sulfamethoxazole-trimethoprim (TMP-SMX)-induced rhabdomyolysis is a rare complication of a commonly used antibiotic. This is a case report of a 43-year old immunocompetent African American woman with a history of depression and chronic alcohol consumption who presented to the emergency department (ED) with worsening bilateral leg pain. Before presentation, the patient was prescribed a twice daily dose of TMP-SMX for a urinary tract infection. The patient reported the development of intensifying leg pain after taking five doses of TMP-SMX. On presentation to the ED she was hemodynamically stable, afebrile, and leg pain intensity 10 out of 10. The patient admitted to daily alcohol consumption and taking vortioxetine 10 mg per day for treatment of depression. Initial labs drawn in the ED showed an elevated creatine kinase (CK) of 26,231 U/L and a normal serum creatinine (SCr) of 1 mg/dL. Through patient history and laboratory tests, common causes of rhabdomyolysis were ruled out. Treatment was initiated with IV fluids plus thiamine and folic acid supplementation, TMP-SMX was discontinued, and vortioxetine 10 mg per day was continued until hospital day five. The patient began to show improvement in lower extremity pain and tenderness and was discharged on hospital day eight with minimal residual leg pain and a CK of 2809 U/L. This case report presents only the third incidence of an immunocompetent patient developing TMP-SMX-induced rhabdomyolysis. This case highlights an opportunity for a pharmacist's intervention and the need for future research to determine risk factors of TMP-SMX-induced rhabdomyolysis in immunocompetent patients.

show abstract

Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant

Cited by 5 publications

References 23 publications

Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature

Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature

Reply

Sulfamethoxazole-Trimethoprim-Induced Rhabdomyolysis in an Immunocompetent Patient: A Case Report

Contact Info

Product

Resources

About