RGD-Conjugated Dendrimer-Modified Gold Nanorods for <i>in Vivo</i> Tumor Targeting and Photothermal Therapy

Li, Zhiming; Huang, Peng; Zhang, Xuejun; Lin, Jing; Yang, Sen; Liu, Bing; Gao, Feng; Xi, Peng; Ren, Qiushi; Cui, Daxiang

doi:10.1021/mp9001415

Cited by 313 publications

(224 citation statements)

References 45 publications

Supporting

Mentioning

221

Contrasting

Order By: Relevance

“…RGD peptide can mediate cell adhesion and proliferation and plays an important role in tumor angiogenesis and metastasis, being considerably upregulated in the endothelium during angiogenesis. Therefore, RGD represents a marker for malignancy [18] and has become a useful tool for the targeting of drugs and probes for functionalized imaging contrast agents [19,20].…”

Section: Resultsmentioning

confidence: 99%

Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia

et al. 2016

Self Cite

View full text Add to dashboard Cite

The development of high-resolution nanosized photoacoustic contrast agents is an exciting yet challenging technological advance. Herein, antibody (breast cancer-associated antigen 1 (Brcaa1) monoclonal antibody)-and peptide (RGD)-functionalized gold nanoprisms (AuNprs) were used as a combinatorial methodology for in situ photoacoustic imaging, angiography, and localized hyperthermia using orthotopic and subcutaneous murine gastric carcinoma models. RGD-conjugated PEGylated AuNprs are available for tumor angiography, and Brcaa1 monoclonal antibody-conjugated PEGylated AuNprs are used for targeting and for in situ imaging of gastric carcinoma in orthotopic tumor models. In situ photoacoustic imaging allowed for anatomical and functional imaging at the tumor site. In vivo tumor angiography imaging showed enhancement of the photoacoustic signal in a time-dependent manner. Furthermore, photoacoustic imaging demonstrated that tumor vessels were clearly damaged after localized hyperthermia. This is the first proof-of-concept using two AuNprs probes as highly sensitive contrasts and therapeutic agents for in situ tumor detection and inhibition. These smart antibody/peptide AuNprs can be used as an efficient nanotheranostic platform for in vivo tumor detection with high sensitivity, as well as for tumor targeting therapy, which, with a single-dose injection, results in tumor size reduction and increases mice survival after localized hyperthermia treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was reported that the systemic TNF toxicity of Aurimune was decreased dramatically compared with TNF alone (For example, the fever side effect was managed) and the target effect was realized. Another product, AuriTol™ (CYT-21001), also from Cytlmmune Sciences, has reached the preclinical stage [46][47][48][49][50].…”

Section: Clinical Translational Prospects Of Theranostic Technologiesmentioning

confidence: 99%

Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

Cui¹,

Ma²,

Zhi³

et al. 2016

Nano BioMed ENG

Self Cite

View full text Add to dashboard Cite

Over the past few years, gastric cancer prewarning and early theranostic system have achieved great advances. Gastric cancer theranostic strategies still focus on prediction and prewarning of early gastric cancer, early diagnosis and molecular imaging directed operation therapy, enhanced immunotherapy and killing gastric cancer stem cells to overcome multidrug resistance (MDR). Here we review the main advances in this field over the past few years, explore the clinical translational prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing gastric cancer prewarning and early theranostic system and promoting clinical translation.

show abstract

“…They found that GNRs showed over 20% accumulation in tumor tissues and the tumors were completely resorpted within 6 days after two times of laser irradiation. Li et al [65] also investigated RGD peptide conjugated GNRs for in vivo photothermal therapy. The results showed that the tumor completely disappeared after four times irradiation within one month.…”

Section: Gnrs In Photothermal Therapy and Drug Deliverymentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

View full text Add to dashboard Cite

Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered.

show abstract

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

Cited by 313 publications

References 45 publications

Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia

Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia

Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

Applications of gold nanorods in biomedical imaging and related fields

Contact Info

Product

Resources

About