Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

Cui, Daxiang; Ma, Lijun; Zhi, Xiaoqin; Zhang, Chunlei

doi:10.5101/nbe.v8i4.p219-239

Cited by 8 publications

(8 citation statements)

References 43 publications

(49 reference statements)

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“…In recent years, metal nanoparticles such as gold, silver, platinum, and copper have attracted the attention and interest of engineers and scientists for specific physical and chemical properties such as their size-dependent surface-plasmon response. , Gold nanoparticles [actually, nanoclusters of gold nanoparticles (hereafter referred to as AuNPs)] and nanorods have promising applications particularly in fields such as biology, biomedicine, − and catalysis . Diverse physical techniques such as thermolysis and irradiation with ultrasound, microwaves, γ-rays, or electron beams − are often used to synthesize AuNPs, but they can also be produced chemically through the reduction of cationic Au(III) by a reducing agent such as sodium citrate, ascorbic acid, or sodium boron hydride. − During these processes, undesirable aggregation of AuNPs is prevented by additives such as thiolate surfactants for dispersion in liquid and metal oxides as solid supports. − Since such chemicals may contaminate the finished AuNPs through infiltration and/or capping and are often toxic to organisms including humans, the use of toxic chemicals to produce AuNPs greatly limits applications in biomedical fields, especially for clinical purposes. ,, …”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Coupled with Nucleic Acid Oxidation

Kunoh¹,

Takeda

Matsumoto³

et al. 2017

ACS Sustainable Chem. Eng.

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Green synthesis of metal nanoparticles, especially gold nanoparticles (AuNPs), has attracted the great interest of scientists and engineers in the medical and pharmaceutical fields; thus, a variety of ecofriendly, energy-and cost-saving techniques have been developed. In this study, we found that cells of Leptothrix (iron-oxidizing bacteria) released extracellular RNA some of which could exist as a constituent of the cell-enclosing sheaths. As a part of studies of metal encrustation in the sheaths, here we show that RNA prepared from the Leptothrix cells can reduce Au(III) and spherical AuNPs eventually form when an aqueous HAuCl 4 solution is added under ambient conditions. RNA and DNA of other organismal origins have the same ability. Of the nucleosides and nucleobases, only guanosine and guanine can form AuNPs. The DNA moiety, 2′-deoxyguanosine (dG) (used as a reference material), forms AuNPs when mixed with HAuCl 4 solution, but 8-hydroxy-2′-deoxyguanosine (8-OHdG) does not, indicating that AuNP formation evidently depends on the reduction potential of the guanine moiety, not the sugar moiety. This finding is the first demonstration that spherical AuNPs of ca. 5 nm diameter can be obtained by simply adding guanine to HAuCl 4 solution at ambient temperature; no other chemicals or physical treatments are needed.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Coupled with Nucleic Acid Oxidation

Kunoh¹,

Takeda

Matsumoto³

et al. 2017

ACS Sustainable Chem. Eng.

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“…Furthermore, the disulfide linker was able to breakdown and release the drugs in response to the highly reductive microenvironment resembling tumor site ( Fig. 3) [36,37].…”

Section: The "Smart" Nano-assembly Small Molecules Probementioning

confidence: 99%

Nano-Assembly Small Molecule Probe - New Horizon for Molecular Imaging

Shen¹

2017

Nano Biomedicine and Engineering

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Molecular imaging allows the biological processes taking place in the body to be viewed at a cellular and molecular level. Molecular imaging probe is used to visualize, characterize and quantify the processes. Nano-assembly small molecule probe provides an attractive means to precisely engineer nanomedicine with distinct biophysicochemical properties and simplify the optimization of formulation, which is an emerging and promising area that can integrate the advantages of the two kinds of molecular imaging probes with high loading capacity, effective signal amplification, preferable clearance, etc. Herein, we review main advances such as small molecules self-assembly into nanoprobes, its development and application, including fluorescent, magnetic resonance imaging, and nuclide marker labeled nano-assembly small molecules probes, as well as "smart" probes of this kind and their applications in molecular imaging.

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“…Local injection of therapeutic agents is widely used in cancer treatment as an assistant chemotherapy to clear the residual cancer cells [11][12][13] and reduce the prevalence of post-operation relapses [14][15][16][17][18]. One can argue that the principles of such local injections are also applicable to RFA treatment.…”

Section: Introductionmentioning

confidence: 99%

“…If anti-tumor drugs were injected in the RFA focuses, a synergistic effect of the drugs and RFA could be obtained. Recently, it has been noted that the residence time of drugs in the therapeutic site is also an important factor to consider when improving the drug effect [14,18,19]. So, in order to increase the effectiveness of the therapeutic agent, one has to establish its effective concentration as well as its residence time.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Nano-Drug Carbomicin Inhibiting the Relapse of Stomach Cancer after Radiofrequency Ablation

Li¹,

Pu²,

Pan³

et al. 2017

Nano Biomedicine and Engineering

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Radiofrequency ablation (RFA) is a promising tumor treatment in clinics, but its use is limited given the high post-RFA recurrence rate. To overcome tumor relapse, RFA needs to be used in combination with a long-lasting treatment. Obviously, the focal injection of antitumor drugs is capable of increasing the effective treatment period. Nano drug delivery systems (NDDS), which allow for a controlled and slow release of drugs, provide a promising strategy to overcome post-RFA tumor recurrence. Our results showed a clear transit area, between the non-ablation tumor area and the ablation necrotic area, indicative of apparent histopathological partition. Focal injection of the NDDS in combination with focally-injected carbomicin (CBMC) is an effective assistant treatment for RFA, as it increases efficiency and inhibits tumor relapse. Focally injected CBMC is a novel strategy which overcomes the disadvantages of RFA and may even cure it.

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Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

Cited by 8 publications

References 43 publications

Green Synthesis of Gold Nanoparticles Coupled with Nucleic Acid Oxidation

Green Synthesis of Gold Nanoparticles Coupled with Nucleic Acid Oxidation

Nano-Assembly Small Molecule Probe - New Horizon for Molecular Imaging

The Effect of the Nano-Drug Carbomicin Inhibiting the Relapse of Stomach Cancer after Radiofrequency Ablation

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