Rezidivierende klinische Mastitiden bei Milchkühen – Bedeutung und Ursachen

Grieger, A.-S.; Zoche-Golob, Veit; Paduch, Jan-Hendrik; Hoedemaker, Martina; Krömker, Volker

doi:10.1055/s-0038-1623218

Cited by 9 publications

(3 citation statements)

References 40 publications

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“…There is a high risk of transmission of S. aureus between animals, especially during the milking process, and the pathogen has the ability to persist as a subclinical infection of the bovine udder. Important virulence factors of S. aureus-isolates enable their adhesion to epithelial cells, encapsulation, the formation of micro abscesses and the formation of biofilms, impeding treatment by antimicrobial agents and promoting a chronic progression [7,8]. Thus, an adequate treatment of S. aureus mastitis requires hygiene and special management routines, with three measures being identified for S. aureus intramammary infections (IMIs): a) separating the positively tested animals, b) culling the chronically infected animals and c) undertaking adequate hygiene and treatment measures [5,9].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Bacteriophages Against Staphylococcus aureus Isolates from Bovine Mastitis

Titze¹,

Lehnherr²,

Lehnherr³

et al. 2020

Pharmaceuticals

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The lytic efficacy of bacteriophages against Staphylococcus aureus isolates from bovine milk was investigated in vitro, regarding possible applications in the therapy of udder inflammation caused by bacterial infections (mastitis). The host range of sequenced, lytic bacteriophages was determined against a collection of 92 Staphylococcus (S.) aureus isolates. The isolates originated from quarter foremilk samples of clinical and subclinical mastitis cases. A spot test and a subsequent plaque assay were used to determine the phage host range. According to their host range, propagation and storage properties, three phages, STA1.ST29, EB1.ST11, and EB1.ST27, were selected for preparing a bacteriophage mixture (1:1:1), which was examined for its lytic activity against S. aureus in pasteurized and raw milk. It was found that almost two thirds of the isolates could be lysed by at least one of the tested phages. The bacteriophage mixture was able to reduce the S. aureus germ density in pasteurized milk and its reduction ability was maintained in raw milk, with only a moderate decrease compared to the results in pasteurized milk. The significant reduction ability of the phage mixture in raw milk promotes further in vivo investigation.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Bacteriophages Against Staphylococcus aureus Isolates from Bovine Mastitis

Titze¹,

Lehnherr²,

Lehnherr³

et al. 2020

Pharmaceuticals

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“…Due to the large percentage of farmers estimating the number of new clinical mastitis cases, over-or underreporting cannot be ruled out. As it turned out in the research conducted by Grieger et al (83), clinical mastitis cases often occur as a recurrence; 6-44% of cases are relapses. This fact could have an impact on the data farmers reported to us.…”

Section: Clinical Mastitis Incidencementioning

confidence: 97%

Status of udder health performance indicators and implementation of on farm monitoring on German dairy cow farms: results from a large scale cross-sectional study

et al. 2023

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Regional benchmarking data enables farmers to compare their animal health situation to that of other herds and identify areas with improvement potential. For the udder health status of German dairy cow farms, such data were incomplete. Therefore, the aim of this study was (1) to describe the incidence of clinical mastitis (CM), (2) to describe cell count based udder health indicators [annual mean test day average of the proportion of animals without indication of mastitis (aWIM), new infection risk during lactation (aNIR), and proportion of cows with low chance of cure (aLCC); heifer mastitis rate (HM)] and their seasonal variation, and (3) to evaluate the level of implementation of selected measures of mastitis monitoring. Herds in three German regions (North: n = 253; East: n = 252, South: n = 260) with different production conditions were visited. Data on CM incidence and measures of mastitis monitoring were collected via structured questionnaire-based interviews. Additionally, dairy herd improvement (DHI) test day data from the 365 days preceding the interview were obtained. The median (Q0.1, Q0.9) farmer reported incidence of mild CM was 14.8% (3.5, 30.8%) in North, 16.2% (1.9, 50.4%) in East, and 11.8% (0.0, 30.7%) in South. For severe CM the reported incidence was 4.0% (0.0, 12.2%), 2.0% (0.0, 10.8%), and 2.6% (0.0, 11.0%) for North, East, and South, respectively. The median aWIM was 60.7% (53.4, 68.1%), 59.0% (49.7, 65.4%), and 60.2% (51.5, 67.8%), whereas the median aNIR was 17.1% (13.6, 21.6%), 19.9% (16.2, 24.9%), and 18.3% (14.4, 22.0%) in North, East, and South, respectively with large seasonal variations. Median aLCC was ≤1.1% (≤ 0.7%, ≤ 1.8%) in all regions and HM was 28.4% (19.7, 37.2%), 35.7% (26.7, 44.2%), and 23.5% (13.1, 35.9%), in North, East and South, respectively. Participation in a DHI testing program (N: 95.7%, E: 98.8%, S: 89.2%) and premilking (N: 91.1%, E: 93.7%, S: 90.2%) were widely used. Several aspects of udder health monitoring, including exact documentation of CM cases, regular microbiological analysis of milk samples and the use of a veterinary herd health consultancy service were not applied on many farms. The results of this study can be used by dairy farmers and their advisors as benchmarks for the assessment of the udder health situation in their herds.

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“…As a result, decreasing the likelihood of BC leads to decreasing efficacy and benefit of antibiotic treatment. Prolonged udder disease is present in cows that have recurrent CM cases or episodes that are interrupted by symptom-free periods with elevated cow SCC - i.e., subclinical mastitis ( 15 , 16 ). Consideration of the CM history in the current lactation and persistent elevation in cow SCC allows a determination of cows with a low probability of BC following antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

Non-inferiority Trial Investigating the Efficacy of Non-steroidal Anti-inflammatory Drugs and Antimicrobial Treatment of Mild to Moderate Clinical Mastitis in Dairy Cows With Long-lasting Udder Diseases

Krömker

Schmenger²,

Klocke³

et al. 2021

Front. Vet. Sci.

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To reduce ineffective antimicrobial usage in the treatment of non-severe clinical mastitis (CM) in cows with long-lasting udder diseases, non-antibiotic therapy with a non-steroidal anti-inflammatory drug (NSAID) was conducted and evaluated in a non-blinded, positively controlled, non-inferiority trial. Therefore, three-time systemic ketoprofen treatment at intervals of 24 h was evaluated in comparison with the reference treatment of solely antibiotic therapy in a field study on nine free-stall dairy farms located in Northern Germany. Cows with previous CM cases in current lactation and/or with long-lasting high somatic cell counts in preceding dairy herd improvement test days were randomly allocated to one of the two treatment groups in cases of mild to moderate CM. Quarter foremilk samples of the affected quarters were taken for cyto-bacteriological investigation before treatment as well as ~14 and 21 d after termination of therapy. Both treatment groups were compared regarding the bacteriological cure (BC) as the primary outcome. Clinical cure (CC) and no CM relapse within 60 d after the end of treatment (no R60) were chosen as secondary outcomes. The study resulted in the following outcomes: Streptococcus uberis was most frequently identified in microbiological culture from pre-treatment samples, followed by Staphylococcus aureus and Escherichia coli and other coliforms. No significant differences between the NSAID treatment and the reference treatment were detected regarding CC and CM recurrence (no R60). Although the sole ketoprofen therapy resulted in a numerically lower likelihood of BC, there were no significant differences to the reference treatment. Considering the selection criteria in this study, the results indicate that in mild to moderate CM cases exclusive treatment with ketoprofen may constitute an alternative to antimicrobial intramammary therapy, providing an opportunity for reduction of antibiotic usage. However, non-inferiority evaluations were inconclusive. Further investigations with a larger sample size are required to confirm the results and to make a distinct statement on non-inferiority.

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Rezidivierende klinische Mastitiden bei Milchkühen – Bedeutung und Ursachen

Cited by 9 publications

References 40 publications

Efficacy of Bacteriophages Against Staphylococcus aureus Isolates from Bovine Mastitis

Efficacy of Bacteriophages Against Staphylococcus aureus Isolates from Bovine Mastitis

Status of udder health performance indicators and implementation of on farm monitoring on German dairy cow farms: results from a large scale cross-sectional study

Non-inferiority Trial Investigating the Efficacy of Non-steroidal Anti-inflammatory Drugs and Antimicrobial Treatment of Mild to Moderate Clinical Mastitis in Dairy Cows With Long-lasting Udder Diseases

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