Reye Syndrome – A Case Report with Review of Literature .

Ghosh, Anirban; Pradhan, Seema V; Swami, Ravi; Talwar, OP

doi:10.31729/jnma.218

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…However, Reye syndrome can present in a child even without a history of aspirin or any other drug ingestion. 7 In neuropathology reports of Reye syndrome patients, no consistent pattern emerged, with nonspecific findings related to secondary effects of hypoglycemia, hypoxia-ischemia, and cerebral edema, with the latter being most likely causative of death. 1 In our case, blood glucose at the time of admission was surprisingly normal.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Findings in Reye Syndrome

et al. 2011

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Magnetic resonance imaging findings in Reye syndrome have been reported only infrequently. A previously well 8-year-old boy presented with repeated episodes of vomiting and abdominal pain followed by altered sensorium and tonic spasms. This occurred 5 days after upper respiratory tract infection. His laboratory data revealed elevated liver enzymes, prolonged prothrombin time, and high blood ammonia levels. Magnetic resonance imaging of the brain done on the day of admission revealed diffuse cerebral edema and signal alterations in brainstem, bilateral thalami, medial temporal lobes, parasagittal cortex, and cerebellar and subcortical white matter. Diffusion restriction was seen in thalami, midbrain, cerebellar white matter, subcortical white matter, and parasaggital cortex in the watershed territory. The patient made a full recovery. Follow-up magnetic resonance imaging after a week revealed complete resolution of all except thalamic lesions. Although diffusion restriction in thalami and midbrain has been reported previously, this is the first report indicating diffusion restriction in subcortical white matter and the parasagittal cortex.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Findings in Reye Syndrome

et al. 2011

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“…A fatal case of Reye's syndrome in a three year old girl has been reported based upon post mortem liver biopsy, which showed the presence of microvesicular steatosis [70]. Two cases of amyloidosis have been reported in a study of renal biopsies in a seven year old retrospective study [71].…”

Section: Resultsmentioning

confidence: 99%

Case reports of metabolic disorders from Nepal

Pandey

2019

Molecular Genetics and Metabolism Reports

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BackgroundThe prevalence of metabolic disease in Nepal is largely unknown. Some consideration has been given by the nepalese government for high prevalence of congenital disorders in some populations, but disorders due to enzymatic deficiencies have not been considered as a class of diseases where timely diagnosis and intervention might be possible. No case for these disorders has been made so far, however, findings of many rare metabolic diseases have been reported in literature by the nepalese medical fraternity.MethodsA search for case reports on metabolic disorders listed according to International Classification of Diseases −11 was performed using the google search engine.ResultsA total of 443 cases have been discovered presented in the literature. This does not include disorders that might be due to lifestyle and behaviour. Most of the reported cases have been identified based on clinical acumen, radiological and histopathological findings.ConclusionsGlucose 6 phosphate dehydrogenase deficiency, Wilson's disease and lysosomal disorders should be considered for early diagnosis through newborn screening along with the acknowledged disorders hypothyroidism and hemoglobinopathies in Nepal. Early intervention in these disorders can significantly reduce morbidity and mortality in infancy.

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“…Of note, improvement in diagnostic methods have also helped to pick out true cases of Reye syndrome, thus reducing the rate of misdiagnoses. [3] especially as some inborn errors of metabolism were previously misdiagnosed as Reye. [4] METHODOLOGY A literature review was performed for articles related to Reye syndrome and aspirin.…”

Section: Introductionmentioning

confidence: 99%

Reye Syndrome: Dangers of Aspirin Use in Children

Ogedegbe,

Okun,

Nnokam

et al. 2022

International Journal of Scientific Advances

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Reye syndrome is a rare and potentially fatal illness that affects the pediatric age group between 6 months – 18 years of age. It is characterized by encephalopathy and fatty degeneration of the liver. The cause is unknown but the disease is usually preceded by a viral illness or aspirin use.Aspirin use historically appears to be an important etiology in the development of Reye syndrome. We found and reviewed 7 published case reports of Reye syndrome after the use of Aspirin, of which six patients were male while one was female and the mean age of patients was 5.5 years(SD=4.25). Reye syndrome has different manifestations ranging from lethargy, irritability, confusion, seizures and death. Diagnosis of this syndrome can be made based on clinical signs and laboratory testing. There’s no test specifically for Reye syndrome, however, liver function test shows elevated levels of liver enzymes (AST and ALT) with increased levels of ammonia. Liver biopsy is also useful in making a diagnosis, showing microvesicular fatty changes. The outcome of Reye Syndrome depends on the level of cerebral dysfunction, with about a third of patients suffering long term neurological deficits.However,when diagnosed and treated early,prognosis for survivors is good and recurrence is rare.

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Reye Syndrome – A Case Report with Review of Literature .

Cited by 4 publications

References 8 publications

Magnetic Resonance Imaging Findings in Reye Syndrome

Magnetic Resonance Imaging Findings in Reye Syndrome

Case reports of metabolic disorders from Nepal

Reye Syndrome: Dangers of Aspirin Use in Children

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